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HUMAN:SET1B
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SETD1B (synonyms: KIAA1076, KMT2G, SET1B) | |
| Protein Name(s) | Histone-lysine N-methyltransferase SETD1B
Lysine N-methyltransferase 2G SET domain-containing protein 1B hSET1B | |
| External Links | ||
| UniProt | Q9UPS6 | |
| EMBL | JF813787 AC079360 AC084018 AB028999 | |
| CCDS | CCDS53838.1 | |
| RefSeq | NP_055863.1 XP_005253915.1 XP_006719359.1 XP_011536355.1 | |
| UniGene | Hs.507122 | |
| PDB | 3UVO 4ES0 | |
| PDBsum | 3UVO 4ES0 | |
| ProteinModelPortal | Q9UPS6 | |
| SMR | Q9UPS6 | |
| BioGrid | 116702 | |
| IntAct | Q9UPS6 | |
| STRING | 9606.ENSP00000267197 | |
| iPTMnet | Q9UPS6 | |
| PhosphoSite | Q9UPS6 | |
| BioMuta | SETD1B | |
| DMDM | 166977692 | |
| EPD | Q9UPS6 | |
| MaxQB | Q9UPS6 | |
| PaxDb | Q9UPS6 | |
| PRIDE | Q9UPS6 | |
| Ensembl | ENST00000542440 ENST00000604567 ENST00000619791 | |
| GeneID | 23067 | |
| KEGG | hsa:23067 | |
| UCSC | uc021rfg.2 | |
| CTD | 23067 | |
| GeneCards | SETD1B | |
| H-InvDB | HIX0011090 | |
| HGNC | HGNC:29187 | |
| HPA | HPA021667 HPA059412 | |
| MIM | 611055 | |
| neXtProt | NX_Q9UPS6 | |
| PharmGKB | PA143485611 | |
| eggNOG | KOG1080 COG2940 | |
| GeneTree | ENSGT00760000119228 | |
| HOGENOM | HOG000168216 | |
| HOVERGEN | HBG055596 | |
| InParanoid | Q9UPS6 | |
| KO | K11422 | |
| OMA | PVMQVDM | |
| OrthoDB | EOG7GQXTT | |
| TreeFam | TF106436 | |
| Reactome | R-HSA-3214841 | |
| GenomeRNAi | 23067 | |
| NextBio | 35510195 | |
| PRO | PR:Q9UPS6 | |
| Proteomes | UP000005640 | |
| Bgee | Q9UPS6 | |
| CleanEx | HS_SETD1B | |
| ExpressionAtlas | Q9UPS6 | |
| Genevisible | Q9UPS6 | |
| GO | GO:0005694 GO:0005737 GO:0035097 GO:0016607 GO:0005654 GO:0048188 GO:0018024 GO:0000166 GO:0003723 GO:0006325 GO:0051568 GO:0006355 GO:0006351 | |
| Gene3D | 3.30.70.330 | |
| InterPro | IPR024657 IPR012677 IPR003616 IPR000504 IPR001214 | |
| Pfam | PF11764 PF00076 PF00856 | |
| SMART | SM00508 SM00360 SM00317 | |
| SUPFAM | SSF54928 | |
| PROSITE | PS50868 PS50102 PS50280 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044648 |
histone H3-K4 dimethylation |
ECO:0000314 |
P |
Figure 2C |
complete | |||||
| GO:0097692 |
histone H3-K4 monomethylation |
ECO:0000314 |
P |
Figure 2C |
complete | |||||
| GO:0080182 |
histone H3-K4 trimethylation |
ECO:0000314 |
P |
Figure 2C |
complete | |||||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048188 |
Set1C/COMPASS complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048188 |
Set1C/COMPASS complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0042800 |
histone methyltransferase activity (H3-K4 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035097 |
histone methyltransferase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8CFT2 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048188 |
Set1C/COMPASS complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051568 |
histone H3-K4 methylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-4827382 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Shinsky, SA et al. (2015) Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation. J. Biol. Chem. 290 6361-75 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Lee, JH et al. (2007) Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. J. Biol. Chem. 282 13419-28 PubMed GONUTS page
- ↑ Lee, JH & Skalnik, DG (2008) Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. Mol. Cell. Biol. 28 609-18 PubMed GONUTS page
- ↑ Wu, M et al. (2008) Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol. Cell. Biol. 28 7337-44 PubMed GONUTS page
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