HUMAN:SET1A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SETD1A (synonyms: KIAA0339 (ECO:0000312 with EMBL:BAA20797.2), KMT2F, SET1, SET1A)
Protein Name(s)	Histone-lysine N-methyltransferase SETD1A Lysine N-methyltransferase 2F SET domain-containing protein 1A hSET1A Set1/Ash2 histone methyltransferase complex subunit SET1
External Links
UniProt	O15047
EMBL	AB002337 AC135048 BC027450 BC035795
CCDS	CCDS32435.1
RefSeq	NP_055527.1 XP_005255780.1 XP_006721169.1 XP_011544296.1 XP_011544297.1 XP_011544298.1
UniGene	Hs.297483
PDB	3S8S 3UVN 4EWR
PDBsum	3S8S 3UVN 4EWR
ProteinModelPortal	O15047
SMR	O15047
BioGrid	115088
DIP	DIP-33494N
IntAct	O15047
STRING	9606.ENSP00000262519
iPTMnet	O15047
PhosphoSite	O15047
BioMuta	SETD1A
EPD	O15047
MaxQB	O15047
PaxDb	O15047
PRIDE	O15047
DNASU	9739
Ensembl	ENST00000262519
GeneID	9739
KEGG	hsa:9739
UCSC	uc002ead.2
CTD	9739
GeneCards	SETD1A
HGNC	HGNC:29010
HPA	HPA020646 HPA058376
MIM	611052
neXtProt	NX_O15047
PharmGKB	PA128394556
eggNOG	KOG1080 COG2940
GeneTree	ENSGT00760000119228
HOGENOM	HOG000154291
HOVERGEN	HBG067119
InParanoid	O15047
KO	K11422
OMA	KAPRGVE
OrthoDB	EOG7GQXTT
PhylomeDB	O15047
TreeFam	TF106436
BRENDA	2.1.1.43
Reactome	R-HSA-3214841
ChiTaRS	SETD1A
GenomeRNAi	9739
NextBio	36651
PRO	PR:O15047
Proteomes	UP000005640
Bgee	O15047
CleanEx	HS_SETD1A
ExpressionAtlas	O15047
Genevisible	O15047
GO	GO:0005694 GO:0035097 GO:0016607 GO:0005654 GO:0005634 GO:0048188 GO:0008013 GO:0042800 GO:0000166 GO:0003723 GO:0006325 GO:0051568 GO:0006355 GO:0006351
Gene3D	3.30.70.330
InterPro	IPR024657 IPR012677 IPR003616 IPR000504 IPR001214
Pfam	PF11764 PF00076 PF00856
SMART	SM00508 SM00360 SM00317
SUPFAM	SSF54928
PROSITE	PS50868 PS50102 PS50280

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0097692	histone H3-K4 monomethylation	PMID:25561738^[1]	ECO:0000314			P		Figure 2C	complete CACAO 11801
	GO:0044648	histone H3-K4 dimethylation	PMID:25561738^[1]	ECO:0000314			P		Figure 2C	complete CACAO 11802
	GO:0080182	histone H3-K4 trimethylation	PMID:25561738^[1]	ECO:0000314			P		Figure 2C	complete CACAO 11803
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	PMID:27141965^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:27141965^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22415	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22723415^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:22723415^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005634) has_direct_input:(PR:000002198)	Seeded From UniProt	complete
involved_in	GO:1902275	regulation of chromatin organization	PMID:27141965^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:27141965^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000167) coincident_with:(ENSEMBL:ENSG00000244734)	Seeded From UniProt	complete
part_of	GO:0048188	Set1C/COMPASS complex	PMID:17998332^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048188	Set1C/COMPASS complex	PMID:18838538^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042800	histone methyltransferase activity (H3-K4 specific)	PMID:20862685^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:17355966^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:17500065^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17500065^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034968	histone lysine methylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0018024	P		Seeded From UniProt	complete
involved_in	GO:0034968	histone lysine methylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0018024	P		Seeded From UniProt	complete
involved_in	GO:0051568	histone H3-K4 methylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0042800	P		Seeded From UniProt	complete
involved_in	GO:0051568	histone H3-K4 methylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042800	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F		Seeded From UniProt	complete
enables	GO:0018024	histone-lysine N-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037841	F		Seeded From UniProt	complete
enables	GO:0042800	histone methyltransferase activity (H3-K4 specific)	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037841	F		Seeded From UniProt	complete
part_of	GO:0048188	Set1C/COMPASS complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037841	C		Seeded From UniProt	complete
enables	GO:0018024	histone-lysine N-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.43	F		Seeded From UniProt	complete
part_of	GO:0048188	Set1C/COMPASS complex	PMID:27141965^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045652	regulation of megakaryocyte differentiation	Reactome:R-HSA-8936459	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8937050 Reactome:R-HSA-8937037 Reactome:R-HSA-8937016 Reactome:R-HSA-8936979 Reactome:R-HSA-8936621 Reactome:R-HSA-8936616 Reactome:R-HSA-8936481 Reactome:R-HSA-8935740 Reactome:R-HSA-5637686 Reactome:R-HSA-5244692 Reactome:R-HSA-5159245	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Shinsky, SA et al. (2015) Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation. J. Biol. Chem. 290 6361-75 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Li, Y et al. (2016) Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation. Nucleic Acids Res. 44 7173-88 PubMed GONUTS page
↑ ^3.0 ^3.1 Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page
↑ Lee, JH & Skalnik, DG (2008) Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. Mol. Cell. Biol. 28 609-18 PubMed GONUTS page
↑ Wu, M et al. (2008) Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol. Cell. Biol. 28 7337-44 PubMed GONUTS page
↑ El Mansouri, FE et al. (2011) Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes. Arthritis Rheum. 63 168-79 PubMed GONUTS page
↑ Lee, JH et al. (2007) Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. J. Biol. Chem. 282 13419-28 PubMed GONUTS page
↑ ^8.0 ^8.1 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

[PMID:25561738-1] 1.0 ^1.1 ^1.2 Shinsky, SA et al. (2015) Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation. J. Biol. Chem. 290 6361-75 PubMed GONUTS page

[PMID:27141965-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Li, Y et al. (2016) Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation. Nucleic Acids Res. 44 7173-88 PubMed GONUTS page

[PMID:22723415-3] 3.0 ^3.1 Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page

[PMID:17998332-4] Lee, JH & Skalnik, DG (2008) Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. Mol. Cell. Biol. 28 609-18 PubMed GONUTS page

[PMID:18838538-5] Wu, M et al. (2008) Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol. Cell. Biol. 28 7337-44 PubMed GONUTS page

[PMID:20862685-6] El Mansouri, FE et al. (2011) Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes. Arthritis Rheum. 63 168-79 PubMed GONUTS page

[PMID:17355966-7] Lee, JH et al. (2007) Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. J. Biol. Chem. 282 13419-28 PubMed GONUTS page

[PMID:17500065-8] 8.0 ^8.1 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

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HUMAN:SET1A

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