HUMAN:SET

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SET
Protein Name(s)	Protein SET HLA-DR-associated protein II Inhibitor of granzyme A-activated DNase IGAAD PHAPII Phosphatase 2A inhibitor I2PP2A I-2PP2A Template-activating factor I TAF-I
External Links
UniProt	Q01105
EMBL	M93651 X75091 D45198 U51924 AY349172 CR536543 CR542050 AK223556 AK300609 AL356481 AL359678 BC032749 EF534308
CCDS	CCDS48037.1 CCDS59150.1
PIR	A57984 I59377
RefSeq	NP_001116293.1 NP_001234929.1 NP_001234930.1 NP_003002.2
UniGene	Hs.436687
PDB	2E50
PDBsum	2E50
ProteinModelPortal	Q01105
SMR	Q01105
BioGrid	112316
DIP	DIP-33561N
IntAct	Q01105
MINT	MINT-4990855
STRING	9606.ENSP00000361777
PhosphoSite	Q01105
DMDM	46397790
MaxQB	Q01105
PaxDb	Q01105
PeptideAtlas	Q01105
PRIDE	Q01105
DNASU	6418
Ensembl	ENST00000322030 ENST00000372686 ENST00000372688 ENST00000372692 ENST00000409104
GeneID	6418
KEGG	hsa:6418
UCSC	uc004bvt.4 uc004bvu.4 uc011mbj.2 uc022bol.1
CTD	6418
GeneCards	GC09P131445
HGNC	HGNC:10760
HPA	CAB005232
MIM	600960
neXtProt	NX_Q01105
PharmGKB	PA35678
eggNOG	NOG260846
GeneTree	ENSGT00530000062882
HOGENOM	HOG000232096
HOVERGEN	HBG014779
InParanoid	Q01105
KO	K11290
OMA	VSEPVNI
PhylomeDB	Q01105
TreeFam	TF313386
Reactome	REACT_172744 REACT_25218
ChiTaRS	SET
EvolutionaryTrace	Q01105
GeneWiki	Protein_SET
GenomeRNAi	6418
NextBio	24926
PRO	PR:Q01105
Proteomes	UP000005640
Bgee	Q01105
CleanEx	HS_SET
ExpressionAtlas	Q01105
Genevestigator	Q01105
GO	GO:0005737 GO:0005829 GO:0005783 GO:0005654 GO:0005634 GO:0048471 GO:0043234 GO:0003677 GO:0042393 GO:0004864 GO:0008601 GO:0006260 GO:0010467 GO:0000278 GO:0016071 GO:0043086 GO:0035067 GO:0043524 GO:0045892 GO:0006913 GO:0006334 GO:0006337 GO:0050790 GO:0016070
InterPro	IPR002164
PANTHER	PTHR11875
Pfam	PF00956

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005634	nucleus	PMID:16791210^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:12524539^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:11555662^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19343227^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:11909973^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:12524539^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:11555662^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12524539^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11909973^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11555662^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:18374643^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99538	P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:18374643^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99490	P	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032515	negative regulation of phosphoprotein phosphatase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004864	P	Seeded From UniProt	complete
involved_in	GO:0043666	regulation of phosphoprotein phosphatase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019888	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002164	C	Seeded From UniProt	complete
involved_in	GO:0006334	nucleosome assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002164	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18374643^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006334	nucleosome assembly	PMID:1630450^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	PMID:7753797^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004864	protein phosphatase inhibitor activity	PMID:8626647^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:11555662^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035067	negative regulation of histone acetylation	PMID:11555662^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019888	protein phosphatase regulator activity	PMID:11555662^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006337	nucleosome disassembly	PMID:11555662^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	Reactome:R-HSA-450520	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-450595 Reactome:R-HSA-450387 Reactome:R-HSA-2429719	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Fan, Z et al. (2003) Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat. Immunol. 4 145-53 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Beresford, PJ et al. (2001) Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J. Biol. Chem. 276 43285-93 PubMed GONUTS page
↑ Kajiwara, Y et al. (2009) FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PLoS ONE 4 e5071 PubMed GONUTS page
↑ ^5.0 ^5.1 Fan, Z et al. (2002) HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol. Cell. Biol. 22 2810-20 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Liu, Z et al. (2008) Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Mol. Cell 29 665-78 PubMed GONUTS page
↑ von Lindern, M et al. (1992) Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. Mol. Cell. Biol. 12 3346-55 PubMed GONUTS page
↑ Nagata, K et al. (1995) Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. Proc. Natl. Acad. Sci. U.S.A. 92 4279-83 PubMed GONUTS page
↑ Li, M et al. (1996) The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. J. Biol. Chem. 271 11059-62 PubMed GONUTS page

[PMID:16791210-1] Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page

[PMID:12524539-2] 2.0 ^2.1 ^2.2 Fan, Z et al. (2003) Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat. Immunol. 4 145-53 PubMed GONUTS page

[PMID:11555662-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Beresford, PJ et al. (2001) Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J. Biol. Chem. 276 43285-93 PubMed GONUTS page

[PMID:19343227-4] Kajiwara, Y et al. (2009) FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PLoS ONE 4 e5071 PubMed GONUTS page

[PMID:11909973-5] 5.0 ^5.1 Fan, Z et al. (2002) HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol. Cell. Biol. 22 2810-20 PubMed GONUTS page

[PMID:18374643-6] 6.0 ^6.1 ^6.2 Liu, Z et al. (2008) Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Mol. Cell 29 665-78 PubMed GONUTS page

[PMID:1630450-7] von Lindern, M et al. (1992) Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. Mol. Cell. Biol. 12 3346-55 PubMed GONUTS page

[PMID:7753797-8] Nagata, K et al. (1995) Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. Proc. Natl. Acad. Sci. U.S.A. 92 4279-83 PubMed GONUTS page

[PMID:8626647-9] Li, M et al. (1996) The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. J. Biol. Chem. 271 11059-62 PubMed GONUTS page

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HUMAN:SET

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