HUMAN:SESN2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SESN2 (synonyms: SEST2)
Protein Name(s)	Sestrin-2 Hi95
External Links
UniProt	P58004
EMBL	AY123223 AL136551 AK027896 AK025640 AK315710 AL353622 CH471059 BC013304 BC033719
CCDS	CCDS321.1
RefSeq	NP_113647.1
UniGene	Hs.469543
ProteinModelPortal	P58004
BioGrid	123724
IntAct	P58004
MINT	MINT-4715291
STRING	9606.ENSP00000253063
PhosphoSite	P58004
DMDM	13633882
MaxQB	P58004
PaxDb	P58004
PRIDE	P58004
DNASU	83667
Ensembl	ENST00000253063
GeneID	83667
KEGG	hsa:83667
UCSC	uc001bps.3
CTD	83667
GeneCards	GC01P028586
HGNC	HGNC:20746
HPA	HPA018191
MIM	607767
neXtProt	NX_P58004
PharmGKB	PA134882791
eggNOG	NOG312456
GeneTree	ENSGT00440000040103
HOGENOM	HOG000232949
HOVERGEN	HBG054648
InParanoid	P58004
KO	K10141
OMA	MENRFEL
OrthoDB	EOG7SBNNF
PhylomeDB	P58004
TreeFam	TF314230
ChiTaRS	SESN2
GeneWiki	SESN2
GenomeRNAi	83667
NextBio	72643
PRO	PR:P58004
Proteomes	UP000005640
Bgee	P58004
CleanEx	HS_SESN2
Genevestigator	P58004
GO	GO:0005737 GO:0005634 GO:0006914 GO:0006635 GO:0046323 GO:0032042 GO:0043491 GO:2000479 GO:0090526 GO:1901031 GO:0009749 GO:0032868 GO:0070328
Gene3D	1.20.1290.10
InterPro	IPR029032 IPR006730
Pfam	PF04636
SUPFAM	SSF69118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0042149	cellular response to glucose starvation	PMID:25263562^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:25040165^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	PMID:15105503^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:23274085^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:23274085^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:23274085^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15105503^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	PMID:15105503^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0032542	sulfiredoxin activity	PMID:15105503^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:25263562^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:24947615^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	PMID:24947615^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:26449471^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0070728	leucine binding	PMID:26449471^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1990253	cellular response to leucine starvation	PMID:26449471^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0061700	GATOR2 complex	PMID:26449471^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071233	cellular response to leucine	PMID:26586190^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:26586190^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	PMID:25457612^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:25457612^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0061700	GATOR2 complex	PMID:25457612^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:1990316	Atg1/ULK1 kinase complex	PMID:25040165^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	PMID:25263562^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0061700	GATOR2 complex	PMID:25263562^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
NOT\|involved_in	GO:0098869	cellular oxidant detoxification	PMID:19113821^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|enables	GO:0032542	sulfiredoxin activity	PMID:19113821^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
colocalizes_with	GO:0061700	GATOR2 complex	PMID:26586190^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0070728	leucine binding	PMID:26586190^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:18692468^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:26612684^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0061700	GATOR2 complex	PMID:26612684^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	PMID:26612684^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	PMID:26612684^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:18692468^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0031932	TORC2 complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58043	C	Seeded From UniProt	complete
colocalizes_with	GO:0031588	nucleotide-activated protein kinase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58043	C	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58043	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P58043	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1990253	cellular response to leucine starvation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004	P	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922997 MGI:MGI:2155278 MGI:MGI:2651874 PANTHER:PTN000280005 UniProtKB:P58004 UniProtKB:P58005 UniProtKB:Q9Y6P5	P	Seeded From UniProt	complete
involved_in	GO:0071233	cellular response to leucine	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004	P	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922997 MGI:MGI:2155278 MGI:MGI:2651874 PANTHER:PTN000280005 UniProtKB:P58004	P	Seeded From UniProt	complete
enables	GO:0070728	leucine binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004 UniProtKB:Q9Y6P5	F	Seeded From UniProt	complete
colocalizes_with	GO:0061700	GATOR2 complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004 UniProtKB:P58005 UniProtKB:Q9Y6P5	C	Seeded From UniProt	complete
colocalizes_with	GO:0031932	TORC2 complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922997 MGI:MGI:2651874 PANTHER:PTN000280005	C	Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004	F	Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004	P	Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000280005 UniProtKB:P58004 UniProtKB:P58005 UniProtKB:Q9Y6P5	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0032042	C	Seeded From UniProt	complete
involved_in	GO:2000479	regulation of cAMP-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:1904504	positive regulation of lipophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0046323	glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0032042	mitochondrial DNA metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	C	Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	C	Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
involved_in	GO:0006111	regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
enables	GO:0005092	GDP-dissociation inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	F	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P58043 ensembl:ENSMUSP00000030724	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006730	C	Seeded From UniProt	complete
involved_in	GO:1901031	regulation of response to reactive oxygen species	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006730	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5631941 Reactome:R-HSA-5631903 Reactome:R-HSA-5629189	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Chantranupong, L et al. (2014) The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep 9 1-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Ro, SH et al. (2014) Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 281 3816-27 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Budanov, AV et al. (2004) Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304 596-600 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Bae, SH et al. (2013) Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 17 73-84 PubMed GONUTS page
↑ ^5.0 ^5.1 Park, HW et al. (2014) Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun 5 4233 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Wolfson, RL et al. (2016) Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351 43-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Saxton, RA et al. (2016) Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science 351 53-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Parmigiani, A et al. (2014) Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep 9 1281-91 PubMed GONUTS page
↑ ^9.0 ^9.1 Woo, HA et al. (2009) Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins. Antioxid. Redox Signal. 11 739-45 PubMed GONUTS page
↑ ^10.0 ^10.1 Budanov, AV & Karin, M (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134 451-60 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Kim, H et al. (2015) Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Nat Commun 6 10025 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25263562-1] 1.0 ^1.1 ^1.2 ^1.3 Chantranupong, L et al. (2014) The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep 9 1-8 PubMed GONUTS page

[PMID:25040165-2] 2.0 ^2.1 Ro, SH et al. (2014) Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J. 281 3816-27 PubMed GONUTS page

[PMID:15105503-3] 3.0 ^3.1 ^3.2 ^3.3 Budanov, AV et al. (2004) Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304 596-600 PubMed GONUTS page

[PMID:23274085-4] 4.0 ^4.1 ^4.2 Bae, SH et al. (2013) Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 17 73-84 PubMed GONUTS page

[PMID:24947615-5] 5.0 ^5.1 Park, HW et al. (2014) Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun 5 4233 PubMed GONUTS page

[PMID:26449471-6] 6.0 ^6.1 ^6.2 ^6.3 Wolfson, RL et al. (2016) Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351 43-8 PubMed GONUTS page

[PMID:26586190-7] 7.0 ^7.1 ^7.2 ^7.3 Saxton, RA et al. (2016) Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science 351 53-8 PubMed GONUTS page

[PMID:25457612-8] 8.0 ^8.1 ^8.2 Parmigiani, A et al. (2014) Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep 9 1281-91 PubMed GONUTS page

[PMID:19113821-9] 9.0 ^9.1 Woo, HA et al. (2009) Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins. Antioxid. Redox Signal. 11 739-45 PubMed GONUTS page

[PMID:18692468-10] 10.0 ^10.1 Budanov, AV & Karin, M (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134 451-60 PubMed GONUTS page

[PMID:26612684-11] 11.0 ^11.1 ^11.2 ^11.3 Kim, H et al. (2015) Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Nat Commun 6 10025 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:SESN2

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