HUMAN:SEMG1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SEMG1 (synonyms: SEMG)
Protein Name(s)	Semenogelin-1 Semenogelin I SGI Alpha-inhibin-92 Alpha-inhibin-31 Seminal basic protein
External Links
UniProt	P04279
EMBL	J04440 Z47556 M81650 AY256465 AY256466 AY256467 AY256468 AY256469 BT007177 AL049767 CH471077 BC007096 BC055416 AY174423 AY174424 AY174437
CCDS	CCDS13345.1
PIR	B43412
RefSeq	NP_002998.1
UniGene	Hs.1968
ProteinModelPortal	P04279
BioGrid	112306
IntAct	P04279
MINT	MINT-2862979
PhosphoSite	P04279
DMDM	134426
MaxQB	P04279
PaxDb	P04279
PRIDE	P04279
DNASU	6406
Ensembl	ENST00000372781
GeneID	6406
KEGG	hsa:6406
UCSC	uc002xni.2 uc002xnj.2
CTD	6406
GeneCards	GC20P043835
HGNC	HGNC:10742
HPA	HPA042476
MIM	182140
neXtProt	NX_P04279
PharmGKB	PA35664
eggNOG	NOG74001
GeneTree	ENSGT00390000020321
HOVERGEN	HBG054194
InParanoid	P04279
OMA	HGENANG
OrthoDB	EOG7J4469
PhylomeDB	P04279
TreeFam	TF342360
Reactome	REACT_75925
GeneWiki	Semenogelin_I
GenomeRNAi	6406
NextBio	24890
PMAP-CutDB	P04279
PRO	PR:P04279
Proteomes	UP000005640
Bgee	P04279
CleanEx	HS_SEMG1
ExpressionAtlas	P04279
Genevestigator	P04279
GO	GO:0005576 GO:0005615 GO:0070062 GO:0005634 GO:0030141 GO:0005198 GO:0007320
InterPro	IPR008836
PANTHER	PTHR10547
Pfam	PF05474

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1901318	negative regulation of sperm motility	PMID:22075473^[1]	ECO:0000314			P		Figure 3: B As Semenogelin-1 (SEMG1) increases, intracellular Calcium levels decrease and motility goes down.	complete CACAO 6729
	GO:0090281	negative regulation of calcium ion import	PMID:22075473^[1]	ECO:0000314			P		Fig 3A: The effects of SEGM1 on PH regulates the Calcium ion import.	complete CACAO 6730
part_of	GO:0005615	extracellular space	PMID:18314226^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:18314226^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:18314226^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:18314226^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8665956^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006530)	Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	PMID:8665956^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q02383) occurs_in:(UBERON:0006530) causally_upstream_of:(GO:0050817)	Seeded From UniProt	complete
involved_in	GO:0050817	coagulation	PMID:8665956^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q02383) occurs_in:(UBERON:0006530)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17567961^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006530)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17567961^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006530)	Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:18714013^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0006530)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18714013^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006530)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8665951^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001968)	Seeded From UniProt	complete
involved_in	GO:1901318	negative regulation of flagellated sperm motility	PMID:19889947^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:2912989^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001968)	Seeded From UniProt	complete
involved_in	GO:1900005	positive regulation of serine-type endopeptidase activity	PMID:15563730^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P07288) directly_regulates:(GO:0008270)	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:15563730^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090281	negative regulation of calcium ion import	PMID:22075473^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901318	negative regulation of flagellated sperm motility	PMID:22075473^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
involved_in	GO:0048240	sperm capacitation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1858275 PANTHER:PTN000057643	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008836	C		Seeded From UniProt	complete
involved_in	GO:0050817	coagulation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008836	P		Seeded From UniProt	complete
involved_in	GO:1901318	negative regulation of flagellated sperm motility	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008836	P		Seeded From UniProt	complete
involved_in	GO:0007320	insemination	PMID:2912989^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:1517240^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(UBERON:0001968)	Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019730	antimicrobial humoral response	Reactome:R-HSA-6803157	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-977136 Reactome:R-HSA-976734 Reactome:R-HSA-6810643	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 O'Rand, MG & Widgren, EE (2012) Loss of calcium in human spermatozoa via EPPIN, the semenogelin receptor. Biol. Reprod. 86 55 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Zhao, H et al. (2008) Identification of novel semenogelin I-derived antimicrobial peptide from liquefied human seminal plasma. Peptides 29 505-11 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Kise, H et al. (1996) Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. Eur. J. Biochem. 238 88-96 PubMed GONUTS page
↑ ^4.0 ^4.1 Wang, Z et al. (2007) Characterization of an eppin protein complex from human semen and spermatozoa. Biol. Reprod. 77 476-84 PubMed GONUTS page
↑ ^5.0 ^5.1 Edström, AM et al. (2008) The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins. J. Immunol. 181 3413-21 PubMed GONUTS page
↑ Malm, J et al. (1996) Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. Eur. J. Biochem. 238 48-53 PubMed GONUTS page
↑ Mitra, A et al. (2010) Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. Biol. Reprod. 82 489-96 PubMed GONUTS page
↑ ^8.0 ^8.1 Lilja, H et al. (1989) Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. J. Biol. Chem. 264 1894-900 PubMed GONUTS page
↑ ^9.0 ^9.1 Jonsson, M et al. (2005) Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. Biochem. J. 387 447-53 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ulvsbäck, M et al. (1992) Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. J. Biol. Chem. 267 18080-4 PubMed GONUTS page

[PMID:22075473-1] 1.0 ^1.1 ^1.2 ^1.3 O'Rand, MG & Widgren, EE (2012) Loss of calcium in human spermatozoa via EPPIN, the semenogelin receptor. Biol. Reprod. 86 55 PubMed GONUTS page

[PMID:18314226-2] 2.0 ^2.1 ^2.2 ^2.3 Zhao, H et al. (2008) Identification of novel semenogelin I-derived antimicrobial peptide from liquefied human seminal plasma. Peptides 29 505-11 PubMed GONUTS page

[PMID:8665956-3] 3.0 ^3.1 ^3.2 Kise, H et al. (1996) Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. Eur. J. Biochem. 238 88-96 PubMed GONUTS page

[PMID:17567961-4] 4.0 ^4.1 Wang, Z et al. (2007) Characterization of an eppin protein complex from human semen and spermatozoa. Biol. Reprod. 77 476-84 PubMed GONUTS page

[PMID:18714013-5] 5.0 ^5.1 Edström, AM et al. (2008) The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins. J. Immunol. 181 3413-21 PubMed GONUTS page

[PMID:8665951-6] Malm, J et al. (1996) Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. Eur. J. Biochem. 238 48-53 PubMed GONUTS page

[PMID:19889947-7] Mitra, A et al. (2010) Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. Biol. Reprod. 82 489-96 PubMed GONUTS page

[PMID:2912989-8] 8.0 ^8.1 Lilja, H et al. (1989) Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. J. Biol. Chem. 264 1894-900 PubMed GONUTS page

[PMID:15563730-9] 9.0 ^9.1 Jonsson, M et al. (2005) Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. Biochem. J. 387 447-53 PubMed GONUTS page

[PMID:23533145-10] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:21630459-11] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:21873635-12] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1517240-13] Ulvsbäck, M et al. (1992) Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. J. Biol. Chem. 267 18080-4 PubMed GONUTS page

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HUMAN:SEMG1

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