HUMAN:RNT2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RNASET2 (synonyms: RNASE6PL)
Protein Name(s)	Ribonuclease T2 Ribonuclease 6
External Links
UniProt	O00584
EMBL	U85625 AJ419865 AJ419866 AK315467 AL133458 AL159163 AL159163 AL133458 CH471051 CH471051 CH471051 BC001660 BC001819 BC039713 BC051912
CCDS	CCDS5295.1
PIR	S78046
RefSeq	NP_003721.2
UniGene	Hs.529989
PDB	3T0O
PDBsum	3T0O
ProteinModelPortal	O00584
SMR	O00584
BioGrid	114188
IntAct	O00584
STRING	9606.ENSP00000028008
PhosphoSite	O00584
MaxQB	O00584
PaxDb	O00584
PeptideAtlas	O00584
PRIDE	O00584
Ensembl	ENST00000421787 ENST00000476238 ENST00000508775
GeneID	8635
KEGG	hsa:8635
UCSC	uc003qve.3
CTD	8635
GeneCards	GC06M167342
HGNC	HGNC:21686
HPA	HPA029013
MIM	612944 612951
neXtProt	NX_O00584
Orphanet	85136
PharmGKB	PA128394541
eggNOG	NOG285082
GeneTree	ENSGT00640000091563
HOVERGEN	HBG050037
InParanoid	O00584
KO	K01166
OMA	QIEICFD
PhylomeDB	O00584
TreeFam	TF315063
ChiTaRS	RNASET2
GeneWiki	RNASET2
GenomeRNAi	8635
NextBio	32371
PRO	PR:O00584
Proteomes	UP000005640
Bgee	O00584
CleanEx	HS_RNASET2
ExpressionAtlas	O00584
Genevestigator	O00584
GO	GO:0005788 GO:0005576 GO:0005615 GO:0070062 GO:0043202 GO:0005764 GO:0004540 GO:0033897 GO:0003723 GO:0006401 GO:0090501
Gene3D	3.90.730.10
InterPro	IPR001568 IPR018188
PANTHER	PTHR11240
Pfam	PF00445
SUPFAM	SSF55895
PROSITE	PS00530 PS00531

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0070062	extracellular exosome	PMID:23533145^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
involved_in	GO:0006401	RNA catabolic process	PMID:22735700^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	PMID:16620762^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:16620762^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16620762^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	PMID:22735700^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006401	RNA catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000133244 SGD:S000006044 UniProtKB:O00584	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000133244 SGD:S000006044 TAIR:locus:2056755	C		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000133244 SGD:S000006044 UniProtKB:P42814	F		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P		Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0033897	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001568 InterPro:IPR018188 InterPro:IPR036430	F		Seeded From UniProt	complete
enables	GO:0033897	ribonuclease T2 activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001568 InterPro:IPR018188 InterPro:IPR036430	F		Seeded From UniProt	complete
involved_in	GO:0006401	RNA catabolic process	PMID:9192857^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:9192857^[6] Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	PMID:9192857^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0096	C		Seeded From UniProt	complete
part_of	GO:0043202	lysosomal lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0156	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^3.0 ^3.1 Thorn, A et al. (2012) Structure and activity of the only human RNase T2. Nucleic Acids Res. 40 8733-42 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Campomenosi, P et al. (2006) Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. Arch. Biochem. Biophys. 449 17-26 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Trubia, M et al. (1997) Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies. Genomics 42 342-4 PubMed GONUTS page

[PMID:23533145-1] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:16502470-2] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:22735700-3] 3.0 ^3.1 Thorn, A et al. (2012) Structure and activity of the only human RNase T2. Nucleic Acids Res. 40 8733-42 PubMed GONUTS page

[PMID:16620762-4] 4.0 ^4.1 ^4.2 Campomenosi, P et al. (2006) Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. Arch. Biochem. Biophys. 449 17-26 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9192857-6] 6.0 ^6.1 ^6.2 Trubia, M et al. (1997) Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies. Genomics 42 342-4 PubMed GONUTS page

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HUMAN:RNT2

Contents

Annotations

Notes

References

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