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HUMAN:RGS4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RGS4 | |
| Protein Name(s) | Regulator of G-protein signaling 4
RGP4 RGS4 | |
| External Links | ||
| UniProt | P49798 | |
| EMBL | U27768 DQ346662 DQ346663 DQ346664 EF054877 AK093959 AK295540 AK296240 AK312250 AF493928 BT007025 AL583850 AL583850 AL583850 CH471067 CH471067 BC000737 BC051869 | |
| CCDS | CCDS1243.1 CCDS44270.1 CCDS44271.1 CCDS44272.1 | |
| PIR | S78221 | |
| RefSeq | NP_001095915.1 NP_001106851.1 NP_001106852.1 NP_005604.1 | |
| UniGene | Hs.386726 | |
| ProteinModelPortal | P49798 | |
| SMR | P49798 | |
| BioGrid | 111931 | |
| DIP | DIP-59092N | |
| IntAct | P49798 | |
| STRING | 9606.ENSP00000397181 | |
| BindingDB | P49798 | |
| ChEMBL | CHEMBL1795091 | |
| PhosphoSite | P49798 | |
| DMDM | 1710146 | |
| PaxDb | P49798 | |
| PRIDE | P49798 | |
| DNASU | 5999 | |
| Ensembl | ENST00000367906 ENST00000367908 ENST00000367909 ENST00000421743 ENST00000527809 | |
| GeneID | 5999 | |
| KEGG | hsa:5999 | |
| UCSC | uc001gcl.4 uc009wuy.3 uc009wuz.3 | |
| CTD | 5999 | |
| GeneCards | GC01P163038 | |
| HGNC | HGNC:10000 | |
| HPA | HPA030802 | |
| MIM | 181500 602516 604906 | |
| neXtProt | NX_P49798 | |
| Orphanet | 3140 | |
| PharmGKB | PA34375 | |
| eggNOG | NOG318241 | |
| GeneTree | ENSGT00760000118903 | |
| HOGENOM | HOG000233512 | |
| HOVERGEN | HBG013233 | |
| InParanoid | P49798 | |
| KO | K16449 | |
| OMA | VCQRVSQ | |
| OrthoDB | EOG7VHSZ5 | |
| PhylomeDB | P49798 | |
| TreeFam | TF315837 | |
| Reactome | REACT_19231 REACT_19333 | |
| ChiTaRS | RGS4 | |
| GeneWiki | RGS4 | |
| GenomeRNAi | 5999 | |
| NextBio | 23389 | |
| PRO | PR:P49798 | |
| Proteomes | UP000005640 | |
| Bgee | P49798 | |
| CleanEx | HS_RGS4 | |
| ExpressionAtlas | P49798 | |
| Genevestigator | P49798 | |
| GO | GO:0005737 GO:0005829 GO:0005886 GO:0043234 GO:0005516 GO:0005096 GO:0000188 GO:0008277 GO:0038032 | |
| Gene3D | 1.10.196.10 | |
| InterPro | IPR016137 IPR024066 | |
| Pfam | PF00615 | |
| PRINTS | PR01301 | |
| SMART | SM00315 | |
| SUPFAM | SSF48097 | |
| PROSITE | PS50132 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Fig.2 |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Fig.4 |
complete | |||||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000463 |
positive regulation of excitatory postsynaptic potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990791 |
dorsal root ganglion development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901380 |
negative regulation of potassium ion transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901379 |
regulation of potassium ion transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900924 |
negative regulation of glycine import across plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0110053 |
regulation of actin filament organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061052 |
negative regulation of cell growth involved in cardiac muscle cell development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060160 |
negative regulation of dopamine receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051924 |
regulation of calcium ion transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045744 |
negative regulation of G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045471 |
response to ethanol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043278 |
response to morphine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042220 |
response to cocaine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010460 |
positive regulation of heart rate |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001975 |
response to amphetamine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001965 |
G-protein alpha-subunit binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49799 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000188 |
inactivation of MAPK activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8982026 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0003924 |
GTPase activity |
Reactome:R-HSA-8982020 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009968 |
negative regulation of signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Chatterjee, TK & Fisher, RA (2000) Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. J. Biol. Chem. 275 24013-21 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Popov, SG et al. (2000) Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. J. Biol. Chem. 275 18962-8 PubMed GONUTS page
- ↑ Druey, KM et al. (1996) Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature 379 742-6 PubMed GONUTS page
c
g
n
- GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway
- GO:1901380 ! negative regulation of potassium ion transmembrane transport
- GO:1900924 ! negative regulation of glycine import across plasma membrane
- GO:0061052 ! negative regulation of cell growth involved in cardiac muscle cell development
- GO:0060160 ! negative regulation of dopamine receptor signaling pathway
- GO:0009968 ! negative regulation of signal transduction
- GO:0005634 ! nucleus
p
r
- GO:0051924 ! regulation of calcium ion transport
- GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
- GO:0110053 ! regulation of actin filament organization
- GO:1901379 ! regulation of potassium ion transmembrane transport
- GO:0045471 ! response to ethanol
- GO:0043278 ! response to morphine
- GO:0042220 ! response to cocaine
- GO:0001975 ! response to amphetamine
