HUMAN:RENT1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	UPF1 (synonyms: KIAA0221, RENT1)
Protein Name(s)	Regulator of nonsense transcripts 1 ATP-dependent helicase RENT1 Nonsense mRNA reducing factor 1 NORF1 Up-frameshift suppressor 1 homolog hUpf1
External Links
UniProt	Q92900
EMBL	U65533 U59323 D86988 AF074016 AC003972 BC039817
CCDS	CCDS12386.1 CCDS74315.1
RefSeq	NP_001284478.1 NP_002902.2
UniGene	Hs.515266
PDB	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5
PDBsum	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5
ProteinModelPortal	Q92900
SMR	Q92900
BioGrid	111908
CORUM	Q92900
DIP	DIP-29875N
IntAct	Q92900
MINT	Q92900
STRING	9606.ENSP00000262803
iPTMnet	Q92900
PhosphoSitePlus	Q92900
SwissPalm	Q92900
BioMuta	UPF1
DMDM	17380291
EPD	Q92900
MaxQB	Q92900
PaxDb	Q92900
PeptideAtlas	Q92900
PRIDE	Q92900
Ensembl	ENST00000262803 ENST00000599848
GeneID	5976
KEGG	hsa:5976
UCSC	uc002nkf.4
CTD	5976
DisGeNET	5976
EuPathDB	HostDB:ENSG00000005007.12
GeneCards	UPF1
HGNC	HGNC:9962
HPA	HPA019587 HPA020857
MIM	601430
neXtProt	NX_Q92900
OpenTargets	ENSG00000005007
PharmGKB	PA34328
eggNOG	KOG1802 COG1112
GeneTree	ENSGT00800000124068
HOGENOM	HOG000205990
HOVERGEN	HBG061556
InParanoid	Q92900
KO	K14326
OMA	QPCAAQN
OrthoDB	EOG091G01B6
PhylomeDB	Q92900
TreeFam	TF300554
Reactome	R-HSA-975956 R-HSA-975957
SIGNOR	Q92900
ChiTaRS	UPF1
EvolutionaryTrace	Q92900
GeneWiki	UPF1
GenomeRNAi	5976
PRO	PR:Q92900
Proteomes	UP000005640
Bgee	ENSG00000005007
CleanEx	HS_UPF1
ExpressionAtlas	Q92900
Genevisible	Q92900
GO	GO:0000785 GO:0005737 GO:0005829 GO:0035145 GO:0000784 GO:0005654 GO:0005634 GO:0000932 GO:0044530 GO:0005524 GO:0004004 GO:0003682 GO:0004386 GO:0003723 GO:0042162 GO:0008270 GO:0061158 GO:0044770 GO:0071347 GO:0071222 GO:0006281 GO:0006260 GO:0009048 GO:0071044 GO:0006406 GO:0000956 GO:0000294 GO:0000184 GO:0061014 GO:0032204 GO:0006449 GO:0032201
InterPro	IPR006935 IPR027417 IPR018999
Pfam	PF04851 PF09416
SUPFAM	SSF52540

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:24726324^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061014	positive regulation of mRNA catabolic process	PMID:24726324^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:24726324^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061014	positive regulation of mRNA catabolic process	PMID:25225333^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q96Q15)	Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:26255671^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:26255671^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:26255671^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061014	positive regulation of mRNA catabolic process	PMID:26255671^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000294	nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay	PMID:26255671^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:21829167^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:21829167^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:17916692^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032201	telomere maintenance via semi-conservative replication	PMID:21829167^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032204	regulation of telomere maintenance	PMID:17916692^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000956	nuclear-transcribed mRNA catabolic process	PMID:23828042^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:16488880^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	PMID:16488880^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004004	ATP-dependent RNA helicase activity	PMID:12554878^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16488880^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:16488880^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071044	histone mRNA catabolic process	PMID:16086026^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0044530	supraspliceosomal complex	PMID:18362360^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035145	exon-exon junction complex	PMID:16601204^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044770	cell cycle phase transition	PMID:16488880^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006449	regulation of translational termination	PMID:9620853^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006449	regulation of translational termination	PMID:10999600^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9064659^[16]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18362360^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	PMID:9064659^[16]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004004	ATP-dependent RNA helicase activity	PMID:21419344^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:10999600^[15]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	PMID:18369367^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	PMID:17468741^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	PMID:10999600^[15]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004004	ATP-dependent RNA helicase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000094512 SGD:S000004685 UniProtKB:Q92900	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000094509 UniProtKB:Q92900 UniProtKB:Q9HCE1	F		Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0030354 PANTHER:PTN000094512 SGD:S000004685 TAIR:locus:2171007 UniProtKB:Q92900 WB:WBGene00004880 ZFIN:ZDB-GENE-040426-2836	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000094512 TAIR:locus:2171007 WB:WBGene00004880 WB:WBGene00016566	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009048	dosage compensation by inactivation of X chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPU0 ensembl:ENSMUSP00000075089	P		Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018999	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935 InterPro:IPR018999	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018999	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935 InterPro:IPR018999	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018999	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018999	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
involved_in	GO:0006406	mRNA export from nucleus	PMID:16488880^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	PMID:8855285^[21] Reactome:R-HSA-927802	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-927889 Reactome:R-HSA-927836 Reactome:R-HSA-927832 Reactome:R-HSA-927830 Reactome:R-HSA-927813 Reactome:R-HSA-927789	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0866	P		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0230	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Gregersen, LH et al. (2014) MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Mol. Cell 54 573-85 PubMed GONUTS page
↑ Fischer-Kešo, R et al. (2014) Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. Mol. Cell. Biol. 34 4244-56 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Mino, T & Takeuchi, O (2015) Regnase-1 and Roquin regulate inflammatory mRNAs. Oncotarget 6 17869-70 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Chawla, R et al. (2011) Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J. 30 4047-58 PubMed GONUTS page
↑ ^5.0 ^5.1 Azzalin, CM et al. (2007) Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 318 798-801 PubMed GONUTS page
↑ Longman, D et al. (2013) DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic Acids Res. 41 8319-31 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Azzalin, CM & Lingner, J (2006) The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr. Biol. 16 433-9 PubMed GONUTS page
↑ Chiu, SY et al. (2003) Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. RNA 9 77-87 PubMed GONUTS page
↑ Kaygun, H & Marzluff, WF (2005) Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat. Struct. Mol. Biol. 12 794-800 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^12.0 ^12.1 Agranat, L et al. (2008) The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus. Proc. Natl. Acad. Sci. U.S.A. 105 5028-33 PubMed GONUTS page
↑ Kunz, JB et al. (2006) Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA 12 1015-22 PubMed GONUTS page
↑ Czaplinski, K et al. (1998) The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev. 12 1665-77 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Bhattacharya, A et al. (2000) Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA 6 1226-35 PubMed GONUTS page
↑ ^16.0 ^16.1 Applequist, SE et al. (1997) Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. Nucleic Acids Res. 25 814-21 PubMed GONUTS page
↑ Chakrabarti, S et al. (2011) Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2. Mol. Cell 41 693-703 PubMed GONUTS page
↑ Woeller, CF et al. (2008) NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep. 9 446-51 PubMed GONUTS page
↑ Morris, C et al. (2007) Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Rep. 8 596-602 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Perlick, HA et al. (1996) Mammalian orthologues of a yeast regulator of nonsense transcript stability. Proc. Natl. Acad. Sci. U.S.A. 93 10928-32 PubMed GONUTS page

[PMID:24726324-1] 1.0 ^1.1 ^1.2 Gregersen, LH et al. (2014) MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Mol. Cell 54 573-85 PubMed GONUTS page

[PMID:25225333-2] Fischer-Kešo, R et al. (2014) Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. Mol. Cell. Biol. 34 4244-56 PubMed GONUTS page

[PMID:26255671-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Mino, T & Takeuchi, O (2015) Regnase-1 and Roquin regulate inflammatory mRNAs. Oncotarget 6 17869-70 PubMed GONUTS page

[PMID:21829167-4] 4.0 ^4.1 ^4.2 Chawla, R et al. (2011) Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J. 30 4047-58 PubMed GONUTS page

[PMID:17916692-5] 5.0 ^5.1 Azzalin, CM et al. (2007) Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 318 798-801 PubMed GONUTS page

[PMID:23828042-6] Longman, D et al. (2013) DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic Acids Res. 41 8319-31 PubMed GONUTS page

[PMID:16488880-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Azzalin, CM & Lingner, J (2006) The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr. Biol. 16 433-9 PubMed GONUTS page

[PMID:12554878-8] Chiu, SY et al. (2003) Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. RNA 9 77-87 PubMed GONUTS page

[PMID:16086026-9] Kaygun, H & Marzluff, WF (2005) Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat. Struct. Mol. Biol. 12 794-800 PubMed GONUTS page

[PMID:22681889-10] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-11] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:18362360-12] 12.0 ^12.1 Agranat, L et al. (2008) The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus. Proc. Natl. Acad. Sci. U.S.A. 105 5028-33 PubMed GONUTS page

[PMID:16601204-13] Kunz, JB et al. (2006) Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA 12 1015-22 PubMed GONUTS page

[PMID:9620853-14] Czaplinski, K et al. (1998) The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev. 12 1665-77 PubMed GONUTS page

[PMID:10999600-15] 15.0 ^15.1 ^15.2 Bhattacharya, A et al. (2000) Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA 6 1226-35 PubMed GONUTS page

[PMID:9064659-16] 16.0 ^16.1 Applequist, SE et al. (1997) Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. Nucleic Acids Res. 25 814-21 PubMed GONUTS page

[PMID:21419344-17] Chakrabarti, S et al. (2011) Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2. Mol. Cell 41 693-703 PubMed GONUTS page

[PMID:18369367-18] Woeller, CF et al. (2008) NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. EMBO Rep. 9 446-51 PubMed GONUTS page

[PMID:17468741-19] Morris, C et al. (2007) Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Rep. 8 596-602 PubMed GONUTS page

[PMID:21873635-20] 20.0 ^20.1 ^20.2 ^20.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8855285-21] Perlick, HA et al. (1996) Mammalian orthologues of a yeast regulator of nonsense transcript stability. Proc. Natl. Acad. Sci. U.S.A. 93 10928-32 PubMed GONUTS page

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HUMAN:RENT1

Contents

Annotations

Notes

References

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