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HUMAN:RBM24

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RBM24 (synonyms: RNPC6)
Protein Name(s) RNA-binding protein 24

RNA-binding motif protein 24 RNA-binding region-containing protein 6

External Links
UniProt Q9BX46
EMBL AK055391
AK095016
AY547318
AL136305
AL136305
BC104810
BC104808
CCDS CCDS4538.1
CCDS47378.1
CCDS47379.1
RefSeq NP_001137413.1
NP_001137414.1
NP_694565.1
UniGene Hs.519904
ProteinModelPortal Q9BX46
SMR Q9BX46
BioGrid 128744
IntAct Q9BX46
MINT MINT-2879164
STRING 9606.ENSP00000368341
iPTMnet Q9BX46
PhosphoSitePlus Q9BX46
BioMuta RBM24
DMDM 74761312
EPD Q9BX46
MaxQB Q9BX46
PaxDb Q9BX46
PeptideAtlas Q9BX46
PRIDE Q9BX46
Ensembl ENST00000318204
ENST00000379052
ENST00000425446
GeneID 221662
KEGG hsa:221662
UCSC uc003nbz.5
CTD 221662
GeneCards RBM24
HGNC HGNC:21539
HPA HPA066927
HPA067231
neXtProt NX_Q9BX46
OpenTargets ENSG00000112183
PharmGKB PA134964569
eggNOG KOG0149
ENOG4111PGT
GeneTree ENSGT00390000002308
HOGENOM HOG000276232
HOVERGEN HBG108399
InParanoid Q9BX46
OMA SSPYIDY
OrthoDB EOG091G13K0
PhylomeDB Q9BX46
TreeFam TF314235
GenomeRNAi 221662
PRO PR:Q9BX46
Proteomes UP000005640
Bgee ENSG00000112183
CleanEx HS_RBM24
ExpressionAtlas Q9BX46
Genevisible Q9BX46
GO GO:0005829
GO:0005654
GO:0003730
GO:0000166
GO:0030154
GO:0043488
GO:0010830
Gene3D 3.30.70.330
InterPro IPR012677
IPR000504
Pfam PF00076
SMART SM00360
SUPFAM SSF54928
PROSITE PS50102

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0061158

3'-UTR-mediated mRNA destabilization

PMID:24375645[1]

ECO:0000314

P

Organism: Homo sapiens. Protein Name: RNA-Binding Protein RBM24. Notes: Figures 5G-H and 6D-E are used. First, the former two figures prove that RBM24 destabilizes the mRNA of p63. The paper states that “the half-life of ΔNp63 mRNA was deceased from 3.7 hours in the control cells to 2.7 hours in cells with RBM24 expression, and the half-life of TAp63 mRNA was deceased from 9.3 hours in the control cells to 7.2 hours in cells with RBM24 expression.” As can be seen in the line graphs, the p63 transcripts destabilize more quickly in the presence of RBM24. Thus, RBM24 is linked to mRNA destabilization. It is also linked to 3’UTR-mediated mRNA destabilization in particular, as proven by Figures 6D-E. As the paper states, “we found that RBM24 had no effect on TAp63α expression from an expression vector that only contains TAp63α coding sequence (Fig. 6D). By contrast, TAp63α expression was significantly inhibited by RBM24 when the TAp63α expression vector contains a full-length p63 3′UTR (Fig. 6E).” In Figure 6D, it can be seen that the relative level of TAp63α barely changed when RBM24 was transfected into the cells. However, in Figure 6E, the level decreased significantly, due to the presence of a 3’UTR region. Thus, the inhibition of p63 occurs by the destabilization of its transcripts, specifically the 3’UTR region of mRNA. This links RBM24 to 3’UTR-mediated mRNA destabilization.

complete
CACAO 12379

enables

GO:0035925

mRNA 3'-UTR AU-rich region binding

PMID:24356969[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:24356969[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1905870

positive regulation of 3'-UTR-mediated mRNA stabilization

PMID:24356969[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:26990106[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000738

positive regulation of stem cell differentiation

PMID:26990106[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061158

3'-UTR-mediated mRNA destabilization

PMID:24375645[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

PMID:24375645[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045663

positive regulation of myoblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5ZMA3

P

Seeded From UniProt

complete

involved_in

GO:2000766

negative regulation of cytoplasmic translation

PMID:29358667[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

PMID:29358667[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:1990825

sequence-specific mRNA binding

PMID:29358667[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:26844700[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010831

positive regulation of myotube differentiation

PMID:26844700[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048255

mRNA stabilization

PMID:29104163[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061157

mRNA destabilization

PMID:29104163[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:29104163[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:1990715

mRNA CDS binding

PMID:29104163[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0097157

pre-mRNA intronic binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:D3Z4I3

F

Seeded From UniProt

complete

involved_in

GO:1902811

positive regulation of skeletal muscle fiber differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:D3Z4I3

P

Seeded From UniProt

complete

involved_in

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:D3Z4I3

P

Seeded From UniProt

complete

involved_in

GO:0043488

regulation of mRNA stability

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:D3Z4I3

P

Seeded From UniProt

complete

involved_in

GO:0010830

regulation of myotube differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:D3Z4I3

P

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:D3Z4I3

F

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001215
FB:FBgn0004237
FB:FBgn0004838
MGI:MGI:1916394
PANTHER:PTN002689974
UniProtKB:P09651
UniProtKB:P19338
UniProtKB:P22626
UniProtKB:Q14103
UniProtKB:Q96EP5
UniProtKB:Q99729

C

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002690849
ZFIN:ZDB-GENE-040628-1

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002544150
UniProtKB:Q9BX46
UniProtKB:Q9H0Z9

C

Seeded From UniProt

complete

enables

GO:0003729

mRNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1889294
PANTHER:PTN002690849
TAIR:locus:2044370
TAIR:locus:2086325
TAIR:locus:2102435
UniProtKB:F4I321
UniProtKB:Q8LF90
UniProtKB:Q9H0Z9
UniProtKB:Q9SHZ6

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104819
MGI:MGI:1330294
MGI:MGI:893588
MGI:MGI:97286
PANTHER:PTN002689974
RGD:1306751
RGD:1310403
RGD:1310906
RGD:3153
RGD:69234
SGD:S000003391
SGD:S000005483
TAIR:locus:2019622
TAIR:locus:2076096
TAIR:locus:2079874
TAIR:locus:2083810
TAIR:locus:2122009
TAIR:locus:2159401
TAIR:locus:2179939
UniProtKB:P19338
UniProtKB:P22626
UniProtKB:P38159
UniProtKB:P62995
UniProtKB:Q03250
UniProtKB:Q13148
UniProtKB:Q14103
UniProtKB:Q9SVM8

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1902811

positive regulation of skeletal muscle fiber differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z4I3
ensembl:ENSMUSP00000043120

P

Seeded From UniProt

complete

enables

GO:0097157

pre-mRNA intronic binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z4I3
ensembl:ENSMUSP00000043120

F

Seeded From UniProt

complete

involved_in

GO:0043488

regulation of mRNA stability

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z4I3
ensembl:ENSMUSP00000043120

P

Seeded From UniProt

complete

involved_in

GO:0010830

regulation of myotube differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z4I3
ensembl:ENSMUSP00000043120

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z4I3
ensembl:ENSMUSP00000043120

C

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z4I3
ensembl:ENSMUSP00000043120

F

Seeded From UniProt

complete

involved_in

GO:0003197

endocardial cushion development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z4I3
ensembl:ENSMUSP00000043120

P

Seeded From UniProt

complete

involved_in

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3Z4I3
ensembl:ENSMUSP00000043120

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR035979

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

involved_in

GO:0006417

regulation of translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0810

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Xu, E et al. (2014) RNA-binding protein RBM24 regulates p63 expression via mRNA stability. Mol. Cancer Res. 12 359-69 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Jiang, Y et al. (2014) Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. J. Biol. Chem. 289 3164-75 PubMed GONUTS page
  3. ↑ 3.0 3.1 Zhang, T et al. (2016) Rbm24 Regulates Alternative Splicing Switch in Embryonic Stem Cell Cardiac Lineage Differentiation. Stem Cells 34 1776-89 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Zhang, M et al. (2018) Rbm24, a target of p53, is necessary for proper expression of p53 and heart development. Cell Death Differ. 25 1118-1130 PubMed GONUTS page
  5. ↑ 5.0 5.1 Cardinali, B et al. (2016) MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells. Cell Death Dis 7 e2086 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Lin, Y et al. (2018) Global profiling of Rbm24 bound RNAs uncovers a multi-tasking RNA binding protein. Int. J. Biochem. Cell Biol. 94 10-21 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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