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HUMAN:RAD52

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RAD52
Protein Name(s) DNA repair protein RAD52 homolog
External Links
UniProt P43351
EMBL U12134
L33262
U27516
AF125948
AF125949
AF125950
AK292160
AK312026
AY527412
AC004803
CH471116
CH471116
CH471116
CH471116
CCDS CCDS8507.2
PIR A57518
RefSeq NP_001284348.1
NP_001284349.1
NP_602296.2
XP_005253777.1
XP_005253778.1
XP_005253784.1
UniGene Hs.410355
PDB 1H2I
1KN0
PDBsum 1H2I
1KN0
DisProt DP00437
ProteinModelPortal P43351
SMR P43351
BioGrid 111830
DIP DIP-333N
IntAct P43351
MINT MINT-2803258
STRING 9606.ENSP00000351284
ChEMBL CHEMBL2362978
PhosphoSite P43351
DMDM 1172823
MaxQB P43351
PaxDb P43351
PRIDE P43351
DNASU 5893
Ensembl ENST00000358495
ENST00000430095
ENST00000461568
ENST00000468231
ENST00000541619
ENST00000544742
ENST00000545564
GeneID 5893
KEGG hsa:5893
UCSC uc001qis.1
uc001qix.1
CTD 5893
GeneCards GC12M001021
HGNC HGNC:9824
MIM 600392
neXtProt NX_P43351
PharmGKB PA34180
eggNOG COG5055
GeneTree ENSGT00390000008766
HOGENOM HOG000237354
HOVERGEN HBG054676
InParanoid P43351
KO K10873
OMA QARYSSC
OrthoDB EOG74XS87
PhylomeDB P43351
TreeFam TF101221
Reactome REACT_2141
REACT_408
ChiTaRS RAD52
EvolutionaryTrace P43351
GeneWiki RAD52
GenomeRNAi 5893
NextBio 22926
PRO PR:P43351
Proteomes UP000005640
Bgee P43351
CleanEx HS_RAD52
ExpressionAtlas P43351
Genevestigator P43351
GO GO:0005654
GO:0005634
GO:0003677
GO:0042802
GO:0000730
GO:0006310
GO:0006281
GO:0006302
GO:0000724
InterPro IPR004585
IPR007232
PANTHER PTHR12132
Pfam PF04098
TIGRFAMs TIGR00607

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051260

protein homooligomerization

PMID:12370410[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:12370410[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:12370410[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

PMID:12370410[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:12370410[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

PMID:8702565[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045002

double-strand break repair via single-strand annealing

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000951175
SGD:S000002217
SGD:S000004494
UniProtKB:A0A1D8PM97

P

Seeded From UniProt

complete

involved_in

GO:0006312

mitotic recombination

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000951175
PomBase:SPAC30D11.10
UniProtKB:Q59NG2

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000951175
PomBase:SPAC30D11.10
SGD:S000002217
SGD:S000004494
UniProtKB:P43351

C

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101949
PANTHER:PTN000951175
PomBase:SPAC30D11.10
SGD:S000004494

P

Seeded From UniProt

complete

involved_in

GO:2000819

regulation of nucleotide-excision repair

PMID:19506022[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

PMID:19506022[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:19506022[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010792

DNA double-strand break processing involved in repair via single-strand annealing

PMID:19506022[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:19506022[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O08760

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19506022[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:19506022[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21804533[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P43351

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:12750383[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P43351

F

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43352
ensembl:ENSMUSP00000125502

P

Seeded From UniProt

complete

involved_in

GO:0010792

DNA double-strand break processing involved in repair via single-strand annealing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43352
ensembl:ENSMUSP00000125502

P

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43352
ensembl:ENSMUSP00000125502

P

Seeded From UniProt

complete

involved_in

GO:0000724

double-strand break repair via homologous recombination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004585

P

Seeded From UniProt

complete

involved_in

GO:0000730

DNA recombinase assembly

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004585

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004585

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007232

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007232

P

Seeded From UniProt

complete

involved_in

GO:0045002

double-strand break repair via single-strand annealing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004585

P

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

PMID:7774919[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7774919[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:7774919[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-75998
Reactome:R-HSA-5693580
Reactome:R-HSA-5693564
Reactome:R-HSA-5686657
Reactome:R-HSA-5686642
Reactome:R-HSA-5686587
Reactome:R-HSA-4568863

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Singleton, MR et al. (2002) Structure of the single-strand annealing domain of human RAD52 protein. Proc. Natl. Acad. Sci. U.S.A. 99 13492-7 PubMed GONUTS page
  2. ↑ Park, MS et al. (1996) Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells. J. Biol. Chem. 271 18996-9000 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 de Souza-Pinto, NC et al. (2009) The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells. Mol. Cell. Biol. 29 4441-54 PubMed GONUTS page
  5. ↑ Honda, M et al. (2011) Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding. EMBO J. 30 3368-82 PubMed GONUTS page
  6. ↑ Baynton, K et al. (2003) WRN interacts physically and functionally with the recombination mediator protein RAD52. J. Biol. Chem. 278 36476-86 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Shen, Z et al. (1995) The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues. Genomics 25 199-206 PubMed GONUTS page
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