HUMAN:PYR1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CAD
Protein Name(s)	CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase
External Links
UniProt	P27708
EMBL	D78586 CH471053 CH471053 CH471053 BC014178 BC065510 M38561
CCDS	CCDS1742.1
PIR	A36240
RefSeq	NP_004332.2
UniGene	Hs.377010
PDB	4BY3 4C6B 4C6C 4C6D 4C6E 4C6F 4C6I 4C6J 4C6K 4C6L 4C6M 4C6N 4C6O 4C6P 4C6Q
PDBsum	4BY3 4C6B 4C6C 4C6D 4C6E 4C6F 4C6I 4C6J 4C6K 4C6L 4C6M 4C6N 4C6O 4C6P 4C6Q
ProteinModelPortal	P27708
SMR	P27708
BioGrid	107243
DIP	DIP-39484N
IntAct	P27708
MINT	MINT-5000537
STRING	9606.ENSP00000264705
BindingDB	P27708
ChEMBL	CHEMBL3093
DrugBank	DB00128 DB00130
MEROPS	C26.952
PhosphoSite	P27708
DMDM	50403731
MaxQB	P27708
PaxDb	P27708
PeptideAtlas	P27708
PRIDE	P27708
Ensembl	ENST00000264705
GeneID	790
KEGG	hsa:790
UCSC	uc002rji.3
CTD	790
GeneCards	GC02P027440
HGNC	HGNC:1424
HPA	CAB007781
MIM	114010
neXtProt	NX_P27708
PharmGKB	PA26023
eggNOG	COG0458
GeneTree	ENSGT00390000015604
HOGENOM	HOG000234584
HOVERGEN	HBG000279
InParanoid	P27708
KO	K11540
OrthoDB	EOG7M6D6F
PhylomeDB	P27708
TreeFam	TF105604
BioCyc	MetaCyc:ENSG00000084774-MONOMER
BRENDA	3.5.2.3
Reactome	REACT_21376
UniPathway	UPA00070 UPA00070 UPA00070
ChiTaRS	CAD
GenomeRNAi	790
NextBio	3214
PMAP-CutDB	P27708
PRO	PR:P27708
Proteomes	UP000005640
Bgee	P27708
CleanEx	HS_CAD
ExpressionAtlas	P27708
Genevestigator	P27708
GO	GO:0042995 GO:0005829 GO:0070062 GO:0016020 GO:0043025 GO:0016363 GO:0005634 GO:0043234 GO:0043195 GO:0070335 GO:0004070 GO:0005524 GO:0004088 GO:0004151 GO:0019899 GO:0042802 GO:0004672 GO:0008270 GO:0006207 GO:0044205 GO:0070409 GO:0035690 GO:0071364 GO:0017144 GO:0007565 GO:0006543 GO:0006541 GO:0007507 GO:0007595 GO:0001889 GO:0055086 GO:0031100 GO:0018107 GO:0046777 GO:0006206 GO:0046134 GO:0014075 GO:0031000 GO:0051414 GO:0033574 GO:0044281 GO:0006228
Gene3D	1.10.1030.10 3.30.1490.20 3.30.470.20 3.40.50.1370 3.40.50.1380 3.40.50.20 3.40.50.880 3.50.30.20
HAMAP	MF_00001 MF_01209
InterPro	IPR006132 IPR006130 IPR002082 IPR006131 IPR011761 IPR013815 IPR013816 IPR006275 IPR005481 IPR005480 IPR006274 IPR002474 IPR005479 IPR005483 IPR029062 IPR002195 IPR017926 IPR011059 IPR011607 IPR016185
Pfam	PF00289 PF02786 PF02787 PF00988 PF00117 PF02142 PF00185 PF02729
PRINTS	PR00100 PR00101 PR00098
SMART	SM01096 SM01097 SM00851
SUPFAM	SSF48108 SSF51338 SSF52021 SSF52317 SSF52335 SSF52440 SSF53671
TIGRFAMs	TIGR00670 TIGR01369 TIGR01368
PROSITE	PS50975 PS00097 PS00866 PS00867 PS00482 PS00483 PS51273

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0016020	membrane	PMID:19946888^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
enables	GO:0070335	aspartate binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	P		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D4A8A0	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D4A8A0	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D4A8A0	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D4A8A0	F		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	P		Seeded From UniProt	complete
involved_in	GO:0017144	drug metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D4A8A0	P		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:9525610^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	P		Seeded From UniProt	complete
involved_in	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15890648^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15890648^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	F		Seeded From UniProt	complete
enables	GO:0004151	dihydroorotase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	F		Seeded From UniProt	complete
enables	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	F		Seeded From UniProt	complete
enables	GO:0004070	aspartate carbamoyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08955	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:15326225^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99638	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:24332717^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	PMID:24332717^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004151	dihydroorotase activity	PMID:24332717^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019240	citrulline biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000150227 RGD:1588606	P		Seeded From UniProt	complete
involved_in	GO:0006807	nitrogen compound metabolic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10134 EcoGene:EG10135 FB:FBgn0003189 PANTHER:PTN000150222 PomBase:SPAC22G7.06c PomBase:SPBC215.08c PomBase:SPBC56F2.09c RGD:1588606 RGD:2395 SGD:S000003666 SGD:S000003870 SGD:S000005829 TAIR:locus:2092369 UniProtKB:O93937 UniProtKB:P27708 UniProtKB:P31327 UniProtKB:P38100 WB:WBGene00004259 ZFIN:ZDB-GENE-021030-4 ZFIN:ZDB-GENE-081105-17 dictyBase:DDB_G0276335	P		Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003189 PANTHER:PTN000150223 PomBase:SPAC22G7.06c RGD:1588606 SGD:S000003666 dictyBase:DDB_G0276335	P		Seeded From UniProt	complete
involved_in	GO:0006228	UTP biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000150227 RGD:1588606	P		Seeded From UniProt	complete
involved_in	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003189 PANTHER:PTN000150227 PomBase:SPAC22G7.06c RGD:1588606 SGD:S000003666 UniProtKB:P27708 ZFIN:ZDB-GENE-021030-4	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000150227 RGD:1588606 UniProtKB:P27708	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10134 EcoGene:EG10135 EcoGene:EG10805 MGI:MGI:891996 PANTHER:PTN000150222 RGD:1588606 RGD:2395 SGD:S000003666 SGD:S000003870 SGD:S000005829 TAIR:locus:2019302 TAIR:locus:2092369 UniProtKB:P27708 UniProtKB:P31327 UniProtKB:P9WIT7 UniProtKB:Q9LVW7	C		Seeded From UniProt	complete
enables	GO:0004151	dihydroorotase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003189 PANTHER:PTN000150227 RGD:1588606 UniProtKB:P27708	F		Seeded From UniProt	complete
contributes_to	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10135 PANTHER:PTN000150223 SGD:S000003870	F		Seeded From UniProt	complete
enables	GO:0004070	aspartate carbamoyltransferase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003189 PANTHER:PTN000150227 PomBase:SPAC22G7.06c RGD:1588606 SGD:S000003666	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24332717^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27708	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0051414	response to cortisol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	F		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	C		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0019240	citrulline biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0017144	drug metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0014075	response to amine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0006228	UTP biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
involved_in	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	C		Seeded From UniProt	complete
enables	GO:0004151	dihydroorotase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	F		Seeded From UniProt	complete
enables	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	F		Seeded From UniProt	complete
enables	GO:0004070	aspartate carbamoyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	F		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8A0 ensembl:ENSRNOP00000030030	P		Seeded From UniProt	complete
enables	GO:0004070	aspartate carbamoyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002082	F		Seeded From UniProt	complete
enables	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006274	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005479 InterPro:IPR011761 InterPro:IPR013815	F		Seeded From UniProt	complete
involved_in	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002082 InterPro:IPR006274	P		Seeded From UniProt	complete
involved_in	GO:0006520	cellular amino acid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006130 InterPro:IPR006131 InterPro:IPR006132 InterPro:IPR036901	P		Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006274	P		Seeded From UniProt	complete
involved_in	GO:0006807	nitrogen compound metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005483 InterPro:IPR006275	P		Seeded From UniProt	complete
enables	GO:0016597	amino acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006130 InterPro:IPR006131 InterPro:IPR036901	F		Seeded From UniProt	complete
enables	GO:0016743	carboxyl- or carbamoyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006130 InterPro:IPR006131 InterPro:IPR006132 InterPro:IPR036901	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006680	F		Seeded From UniProt	complete
enables	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011059	F		Seeded From UniProt	complete
enables	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002195	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011761	F		Seeded From UniProt	complete
enables	GO:0004070	aspartate carbamoyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.3.2	F		Seeded From UniProt	complete
enables	GO:0004151	dihydroorotase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.2.3	F		Seeded From UniProt	complete
enables	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.3.5.5	F		Seeded From UniProt	complete
involved_in	GO:0046134	pyrimidine nucleoside biosynthetic process	Reactome:R-HSA-500753	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-73577 Reactome:R-HSA-73573 Reactome:R-HSA-73571	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021 UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006221	pyrimidine nucleotide biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0665	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021 UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0044205	'de novo' UMP biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00070	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ Angeletti, PC & Engler, JA (1998) Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix. J. Virol. 72 2896-904 PubMed GONUTS page
↑ ^4.0 ^4.1 Sigoillot, FD et al. (2005) Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J. Biol. Chem. 280 25611-20 PubMed GONUTS page
↑ Lindsey-Boltz, LA et al. (2004) The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD. Nucleic Acids Res. 32 4524-30 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Grande-García, A et al. (2014) Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure 22 185-98 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19946888-1] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:20458337-2] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:9525610-3] Angeletti, PC & Engler, JA (1998) Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix. J. Virol. 72 2896-904 PubMed GONUTS page

[PMID:15890648-4] 4.0 ^4.1 Sigoillot, FD et al. (2005) Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J. Biol. Chem. 280 25611-20 PubMed GONUTS page

[PMID:15326225-5] Lindsey-Boltz, LA et al. (2004) The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD. Nucleic Acids Res. 32 4524-30 PubMed GONUTS page

[PMID:24332717-6] 6.0 ^6.1 ^6.2 ^6.3 Grande-García, A et al. (2014) Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD. Structure 22 185-98 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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