HUMAN:PTN22

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTPN22 (synonyms: PTPN8)
Protein Name(s)	Tyrosine-protein phosphatase non-receptor type 22 Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP Lymphoid phosphatase LyP PEST-domain phosphatase PEP
External Links
UniProt	Q9Y2R2
EMBL	AF001846 AF001847 GU479452 AF077031 AK310570 EF064714 AL137856 CH471122 CH471122 BC017785 BC071670
CCDS	CCDS863.1 CCDS864.2
RefSeq	NP_001180360.1 NP_036543.4 NP_057051.3
UniGene	Hs.535276
PDB	2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51
PDBsum	2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51
ProteinModelPortal	Q9Y2R2
SMR	Q9Y2R2
BioGrid	117604
DIP	DIP-29953N
IntAct	Q9Y2R2
STRING	9606.ENSP00000352833
BindingDB	Q9Y2R2
ChEMBL	CHEMBL2889
DEPOD	Q9Y2R2
PhosphoSite	Q9Y2R2
DMDM	20139861
MaxQB	Q9Y2R2
PaxDb	Q9Y2R2
PRIDE	Q9Y2R2
DNASU	26191
Ensembl	ENST00000460620
GeneID	26191
KEGG	hsa:26191
UCSC	uc001eds.3 uc001edt.3 uc009wgq.3 uc009wgs.2 uc021orx.1
CTD	26191
GeneCards	GC01M114356
HGNC	HGNC:9652
HPA	CAB012209 HPA004912 HPA013350
MIM	152700 600716
neXtProt	NX_Q9Y2R2
Orphanet	397 900 85408 85410 93552 536 3437
PharmGKB	PA33995
eggNOG	COG5599
GeneTree	ENSGT00770000120452
HOVERGEN	HBG103877
InParanoid	Q9Y2R2
KO	K18024
OrthoDB	EOG744T8Z
PhylomeDB	Q9Y2R2
TreeFam	TF351977
SignaLink	Q9Y2R2
ChiTaRS	PTPN22
EvolutionaryTrace	Q9Y2R2
GeneWiki	PTPN22
GenomeRNAi	26191
NextBio	35503189
PRO	PR:Q9Y2R2
Proteomes	UP000005640
Bgee	Q9Y2R2
CleanEx	HS_PTPN22
ExpressionAtlas	Q9Y2R2
Genevestigator	Q9Y2R2
GO	GO:0005737 GO:0009898 GO:0005634 GO:0048471 GO:0019900 GO:0004725 GO:0017124 GO:0050868 GO:0050860 GO:0035335 GO:0035644 GO:0006470 GO:0050855 GO:0045088 GO:0032817 GO:0030217
Gene3D	3.90.190.10
InterPro	IPR029021 IPR016276 IPR000387 IPR016130 IPR000242
PANTHER	PTHR19134:SF260
Pfam	PF00102
PIRSF	PIRSF000930
PRINTS	PR00700
SMART	SM00194
SUPFAM	SSF52799
PROSITE	PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:23871208^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576) happens_during:(GO:0071225)	Seeded From UniProt	complete
involved_in	GO:1903753	negative regulation of p38MAPK cascade	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23871208^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000235) has_regulation_target:(UniProtKB:P01574) part_of:(GO:0034141) has_regulation_target:(UniProtKB:P20591) has_regulation_target:(UniProtKB:P09914) has_regulation_target:(UniProtKB:P09913) has_regulation_target:(UniProtKB:P05161) has_input:(CHEBI:84491)\|occurs_in(CL:0000235) has_regulation_target:(UniProtKB:P01574) happens_during:(GO:0032496) part_of:(GO:0034145) has_regulation_target:(UniProtKB:P20591) has_regulation_target:(UniProtKB:P09914) has_regulation_target:(UniProtKB:P09913) has_regulation_target:(UniProtKB:P05161)	Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576) has_input:(UniProtKB:Q9GZQ8) has_input:(UniProtKB:O95352) has_input:(UniProtKB:Q13501)	Seeded From UniProt	complete
involved_in	GO:2000483	negative regulation of interleukin-8 secretion	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576) happens_during:(GO:0071225)	Seeded From UniProt	complete
involved_in	GO:1902715	positive regulation of interferon-gamma secretion	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576) happens_during:(GO:0071225)	Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576) happens_during:(GO:0071225)	Seeded From UniProt	complete
involved_in	GO:1900165	negative regulation of interleukin-6 secretion	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576) happens_during:(GO:0071225) has_regulation_target:(UniProtKB:P10145) has_regulation_target:(UniProtKB:P05231) has_regulation_target:(UniProtKB:P01375)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0071225) occurs_in:(CL:0000576) has_regulation_target:(UniProtKB:Q9HC29) has_regulation_target:(UniProtKB:P05362) has_regulation_target:(UniProtKB:P01579) has_regulation_target:(UniProtKB:Q9UL17)	Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	PMID:23991106^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000576) happens_during:(GO:0071225)	Seeded From UniProt	complete
involved_in	GO:1901222	regulation of NIK/NF-kappaB signaling	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0071225) occurs_in:(CL:0000576)\|occurs_in:(CL:0000576) happens_during:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0043508	negative regulation of JUN kinase activity	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576) happens_during:(GO:0071225)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576) happens_during:(GO:0071225)\|occurs_in(CL:0000576) part_of:(GO:0031663)	Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:23991106^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000576) causally_upstream_of:(GO:1903753) causally_upstream_of:(GO:0070374)	Seeded From UniProt	complete
involved_in	GO:0071225	cellular response to muramyl dipeptide	PMID:23991106^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000576) causally_upstream_of:(GO:0043508) causally_upstream_of:(GO:0070374)	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:23871208^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902523	positive regulation of protein K63-linked ubiquitination	PMID:23871208^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0032496) occurs_in:(CL:0002476) has_regulation_target:(UniProtKB:Q13114)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:23871208^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13114	F	occurs_in:(CL:0000782)	Seeded From UniProt	complete
involved_in	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	PMID:23871208^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	PMID:23871208^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0050868	negative regulation of T cell activation	PMID:18299186^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050855	regulation of B cell receptor signaling pathway	PMID:19265110^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:10068674^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045088	regulation of innate immune response	PMID:20522204^[6]	ECO:0000305	curator inference used in manual assertion	GO:0032817	P		Seeded From UniProt	complete
involved_in	GO:0035644	phosphoanandamide dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29352	P		Seeded From UniProt	complete
involved_in	GO:0032817	regulation of natural killer cell proliferation	PMID:20522204^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29352	P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29352	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29352	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:10068674^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10068674^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:10068674^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:16461343^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050860	negative regulation of T cell receptor signaling pathway	PMID:18056643^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:10940933^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10940933^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10940933^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:18056643^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004725	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130 InterPro:IPR016276	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
involved_in	GO:0050856	regulation of T cell receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016276	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:21044313^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20401454^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8855381 Reactome:R-HSA-8855375 Reactome:R-HSA-8852200	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	Reactome:R-HSA-8855381 Reactome:R-HSA-8852200	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Wang, Y et al. (2013) The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity 39 111-22 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 Spalinger, MR et al. (2013) Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy. PLoS ONE 8 e72384 PubMed GONUTS page
↑ Aarnisalo, J et al. (2008) Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant. J. Autoimmun. 31 13-21 PubMed GONUTS page
↑ Arechiga, AF et al. (2009) Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J. Immunol. 182 3343-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Cohen, S et al. (1999) Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood 93 2013-24 PubMed GONUTS page
↑ ^6.0 ^6.1 Douroudis, K et al. (2010) PTPN22 gene regulates natural killer cell proliferation during in vitro expansion. Tissue Antigens 76 315-8 PubMed GONUTS page
↑ Wu, J et al. (2006) Identification of substrates of human protein-tyrosine phosphatase PTPN22. J. Biol. Chem. 281 11002-10 PubMed GONUTS page
↑ ^8.0 ^8.1 Yu, X et al. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc. Natl. Acad. Sci. U.S.A. 104 19767-72 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Gjörloff-Wingren, A et al. (2000) Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Eur. J. Immunol. 30 2412-21 PubMed GONUTS page
↑ Wang, S et al. (2010) Identification of a variant form of tyrosine phosphatase LYP. BMC Mol. Biol. 11 78 PubMed GONUTS page
↑ Chen, M et al. (2010) [Research progress of several protein tyrosine phosphatases in diabetes]. Sheng Li Xue Bao 62 179-89 PubMed GONUTS page

[PMID:23871208-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Wang, Y et al. (2013) The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity 39 111-22 PubMed GONUTS page

[PMID:23991106-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 Spalinger, MR et al. (2013) Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy. PLoS ONE 8 e72384 PubMed GONUTS page

[PMID:18299186-3] Aarnisalo, J et al. (2008) Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant. J. Autoimmun. 31 13-21 PubMed GONUTS page

[PMID:19265110-4] Arechiga, AF et al. (2009) Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J. Immunol. 182 3343-7 PubMed GONUTS page

[PMID:10068674-5] 5.0 ^5.1 ^5.2 ^5.3 Cohen, S et al. (1999) Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood 93 2013-24 PubMed GONUTS page

[PMID:20522204-6] 6.0 ^6.1 Douroudis, K et al. (2010) PTPN22 gene regulates natural killer cell proliferation during in vitro expansion. Tissue Antigens 76 315-8 PubMed GONUTS page

[PMID:16461343-7] Wu, J et al. (2006) Identification of substrates of human protein-tyrosine phosphatase PTPN22. J. Biol. Chem. 281 11002-10 PubMed GONUTS page

[PMID:18056643-8] 8.0 ^8.1 Yu, X et al. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc. Natl. Acad. Sci. U.S.A. 104 19767-72 PubMed GONUTS page

[PMID:10940933-9] 9.0 ^9.1 ^9.2 Gjörloff-Wingren, A et al. (2000) Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Eur. J. Immunol. 30 2412-21 PubMed GONUTS page

[PMID:21044313-10] Wang, S et al. (2010) Identification of a variant form of tyrosine phosphatase LYP. BMC Mol. Biol. 11 78 PubMed GONUTS page

[PMID:20401454-11] Chen, M et al. (2010) [Research progress of several protein tyrosine phosphatases in diabetes]. Sheng Li Xue Bao 62 179-89 PubMed GONUTS page

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HUMAN:PTN22

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