HUMAN:PTN1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTPN1 (synonyms: PTP1B)
Protein Name(s)	Tyrosine-protein phosphatase non-receptor type 1 Protein-tyrosine phosphatase 1B PTP-1B
External Links
UniProt	P18031
EMBL	M31724 M33689 M33684 M33688 M33687 M33686 M33685 BT006752 AL133230 AL034429 AL034429 AL133230 BC015660 BC018164
CCDS	CCDS13430.1
PIR	A35992
RefSeq	NP_001265547.1 NP_002818.1
UniGene	Hs.417549
PDB	1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1WAX 1XBO 2AZR 2B07 2B4S 2BGD 2BGE 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2CNE 2CNF 2CNG 2CNH 2CNI 2F6F 2F6T 2F6V 2F6W 2F6Y 2F6Z 2F70 2F71 2FJM 2FJN 2H4G 2H4K 2HB1 2HNP 2HNQ 2NT7 2NTA 2QBP 2QBQ 2QBR 2QBS 2VEU 2VEV 2VEW 2VEX 2VEY 2ZMM 2ZN7 3A5J 3A5K 3CWE 3D9C 3EAX 3EB1 3EU0 3I7Z 3I80 3QKP 3QKQ 3SME 3ZMP 3ZMQ 3ZV2 4BJO 4I8N
PDBsum	1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1NL9 1NNY 1NO6 1NWE 1NWL 1NZ7 1OEM 1OEO 1OES 1OET 1OEU 1OEV 1ONY 1ONZ 1PA1 1PH0 1PTT 1PTU 1PTV 1PTY 1PXH 1PYN 1Q1M 1Q6J 1Q6M 1Q6N 1Q6P 1Q6S 1Q6T 1QXK 1SUG 1T48 1T49 1T4J 1WAX 1XBO 2AZR 2B07 2B4S 2BGD 2BGE 2CM2 2CM3 2CM7 2CM8 2CMA 2CMB 2CMC 2CNE 2CNF 2CNG 2CNH 2CNI 2F6F 2F6T 2F6V 2F6W 2F6Y 2F6Z 2F70 2F71 2FJM 2FJN 2H4G 2H4K 2HB1 2HNP 2HNQ 2NT7 2NTA 2QBP 2QBQ 2QBR 2QBS 2VEU 2VEV 2VEW 2VEX 2VEY 2ZMM 2ZN7 3A5J 3A5K 3CWE 3D9C 3EAX 3EB1 3EU0 3I7Z 3I80 3QKP 3QKQ 3SME 3ZMP 3ZMQ 3ZV2 4BJO 4I8N
ProteinModelPortal	P18031
SMR	P18031
BioGrid	111736
DIP	DIP-38014N
IntAct	P18031
MINT	MINT-441655
STRING	9606.ENSP00000360683
BindingDB	P18031
ChEMBL	CHEMBL335
DrugBank	DB01133
DEPOD	P18031
PhosphoSite	P18031
DMDM	131467
OGP	P18031
MaxQB	P18031
PaxDb	P18031
PeptideAtlas	P18031
PRIDE	P18031
DNASU	5770
Ensembl	ENST00000371621
GeneID	5770
KEGG	hsa:5770
UCSC	uc002xvl.3
CTD	5770
GeneCards	GC20P049126
H-InvDB	HIX0027718
HGNC	HGNC:9642
HPA	CAB009329 CAB015217 HPA012542
MIM	176885
neXtProt	NX_P18031
PharmGKB	PA33985
eggNOG	COG5599
GeneTree	ENSGT00770000120472
HOGENOM	HOG000273908
HOVERGEN	HBG008321
InParanoid	P18031
KO	K05696
OMA	MCMATVL
OrthoDB	EOG7RV9G4
PhylomeDB	P18031
TreeFam	TF315897
BRENDA	3.1.3.48
Reactome	REACT_111133 REACT_15523 REACT_24980 REACT_25216
SABIO-RK	P18031
SignaLink	P18031
ChiTaRS	PTPN1
EvolutionaryTrace	P18031
GeneWiki	PTPN1
GenomeRNAi	5770
NextBio	22442
PMAP-CutDB	P18031
PRO	PR:P18031
Proteomes	UP000005640
Bgee	P18031
CleanEx	HS_PTPN1
ExpressionAtlas	P18031
Genevestigator	P18031
GO	GO:0031410 GO:0005829 GO:0005769 GO:0005783 GO:0005789 GO:0097443 GO:0019899 GO:0046875 GO:0044822 GO:0019901 GO:0004725 GO:0030971 GO:0008270 GO:0031532 GO:0007596 GO:0019221 GO:0030968 GO:0008286 GO:0060333 GO:0060397 GO:0070373 GO:0046627 GO:0030948 GO:0035335 GO:1990264 GO:0030168 GO:0035791 GO:0030100 GO:1902202 GO:0060334 GO:0009966 GO:0060338 GO:0060337
Gene3D	3.90.190.10
InterPro	IPR029021 IPR012265 IPR000387 IPR016130 IPR000242
Pfam	PF00102
PIRSF	PIRSF000926
PRINTS	PR00700
SMART	SM00194
SUPFAM	SSF52799
PROSITE	PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033157	regulation of intracellular protein transport	PMID:22045810^[1]	ECO:0000315			P		Figs. 2AB, 3ABC, 4BC, 5B, and 6B	complete CACAO 2696
	GO:2000646	positive regulation of receptor catabolic process	PMID:22045810^[1]	ECO:0000315			P		Fig. 1BC, 4A, S4	complete CACAO 2697
	GO:0006470	protein dephosphorylation	PMID:22045810^[1]	ECO:0000315			P		Fig. 1A and Fig. 7A	complete CACAO 2698
	GO:0043407	negative regulation of MAP kinase activity	PMID:22045810^[1]	ECO:0000315			P		Fig. 1A and Fig. 4D	complete CACAO 2699
enables	GO:0045296	cadherin binding	PMID:25468996^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	PMID:22045810^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:22045810^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000646	positive regulation of receptor catabolic process	PMID:22045810^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033157	regulation of intracellular protein transport	PMID:22045810^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:21216966^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0034976) has_regulation_target:(PR:000002997) occurs_in:(UBERON:0001264)	Seeded From UniProt	complete
involved_in	GO:1903898	negative regulation of PERK-mediated unfolded protein response	PMID:21216966^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001264)	Seeded From UniProt	complete
part_of	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	PMID:1739967^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35821	P		Seeded From UniProt	complete
part_of	GO:0097443	sorting endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35821	C		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35821	P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:11742412^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35821	P		Seeded From UniProt	complete
involved_in	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway	PMID:18819921^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	PMID:21135139^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29320	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	PMID:14966296^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:14966296^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:21135139^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:21135139^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:18819921^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08581	F		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:22169477^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030100	regulation of endocytosis	PMID:21135139^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:22169477^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NZJ5	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:22169477^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P32929	F		Seeded From UniProt	complete
involved_in	GO:0009966	regulation of signal transduction	PMID:21135139^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:18074158^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	PMID:21135139^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:21135139^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:22169477^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:18074158^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:28246125^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:21707536^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P06213)	Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20417 ensembl:ENSRNOP00000014309	F		Seeded From UniProt	complete
involved_in	GO:0046626	regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20417 ensembl:ENSRNOP00000014309	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20417 ensembl:ENSRNOP00000014309	C		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20417 ensembl:ENSRNOP00000014309	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20417 ensembl:ENSRNOP00000014309	C		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20417 ensembl:ENSRNOP00000014309	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20417 ensembl:ENSRNOP00000014309	F		Seeded From UniProt	complete
involved_in	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:1903898	negative regulation of PERK-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
part_of	GO:0097443	sorting endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	C		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012265 InterPro:IPR016130	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012265	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	PMID:22013210^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903896	positive regulation of IRE1-mediated unfolded protein response	PMID:22013210^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	Reactome:R-HSA-982772	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060338	regulation of type I interferon-mediated signaling pathway	Reactome:R-HSA-912694	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	Reactome:R-HSA-8849472	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-997311 Reactome:R-HSA-9023549 Reactome:R-HSA-8849435 Reactome:R-HSA-8849428 Reactome:R-HSA-6807027 Reactome:R-HSA-377643 Reactome:R-HSA-1169192 Reactome:R-HSA-1168445	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	Reactome:R-HSA-997311 Reactome:R-HSA-8849435 Reactome:R-HSA-377643 Reactome:R-HSA-1169192	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Sangwan, V et al. (2011) Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. J. Biol. Chem. 286 45000-13 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^3.0 ^3.1 Bettaieb, A et al. (2011) Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. J. Biol. Chem. 286 9225-35 PubMed GONUTS page
↑ Frangioni, JV et al. (1992) The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell 68 545-60 PubMed GONUTS page
↑ Saltiel, AR & Kahn, CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414 799-806 PubMed GONUTS page
↑ ^6.0 ^6.1 Sangwan, V et al. (2008) Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J. Biol. Chem. 283 34374-83 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Nievergall, E et al. (2010) PTP1B regulates Eph receptor function and trafficking. J. Cell Biol. 191 1189-203 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^9.0 ^9.1 Persson, C et al. (2004) Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol. Cell. Biol. 24 2190-201 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Krishnan, N et al. (2011) H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal 4 ra86 PubMed GONUTS page
↑ ^11.0 ^11.1 Krezel, A & Maret, W (2008) Thionein/metallothionein control Zn(II) availability and the activity of enzymes. J. Biol. Inorg. Chem. 13 401-9 PubMed GONUTS page
↑ Fu, B et al. (2017) ZMPSTE24 defends against influenza and other pathogenic viruses. J. Exp. Med. 214 919-929 PubMed GONUTS page
↑ Wu, CL et al. (2011) Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling. Biochem. J. 439 151-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page

[PMID:22045810-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Sangwan, V et al. (2011) Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. J. Biol. Chem. 286 45000-13 PubMed GONUTS page

[PMID:25468996-2] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:21216966-3] 3.0 ^3.1 Bettaieb, A et al. (2011) Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. J. Biol. Chem. 286 9225-35 PubMed GONUTS page

[PMID:1739967-4] Frangioni, JV et al. (1992) The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell 68 545-60 PubMed GONUTS page

[PMID:11742412-5] Saltiel, AR & Kahn, CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414 799-806 PubMed GONUTS page

[PMID:18819921-6] 6.0 ^6.1 Sangwan, V et al. (2008) Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J. Biol. Chem. 283 34374-83 PubMed GONUTS page

[PMID:21135139-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Nievergall, E et al. (2010) PTP1B regulates Eph receptor function and trafficking. J. Cell Biol. 191 1189-203 PubMed GONUTS page

[PMID:22658674-8] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:14966296-9] 9.0 ^9.1 Persson, C et al. (2004) Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol. Cell. Biol. 24 2190-201 PubMed GONUTS page

[PMID:22169477-10] 10.0 ^10.1 ^10.2 ^10.3 Krishnan, N et al. (2011) H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal 4 ra86 PubMed GONUTS page

[PMID:18074158-11] 11.0 ^11.1 Krezel, A & Maret, W (2008) Thionein/metallothionein control Zn(II) availability and the activity of enzymes. J. Biol. Inorg. Chem. 13 401-9 PubMed GONUTS page

[PMID:28246125-12] Fu, B et al. (2017) ZMPSTE24 defends against influenza and other pathogenic viruses. J. Exp. Med. 214 919-929 PubMed GONUTS page

[PMID:21707536-13] Wu, CL et al. (2011) Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling. Biochem. J. 439 151-9 PubMed GONUTS page

[PMID:22013210-14] 14.0 ^14.1 Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page

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