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PMID:11742412

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Citation

Saltiel, AR and Kahn, CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806

Abstract

The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver become less responsive or resistant to insulin. This state is also linked to other common health problems, such as obesity, polycystic ovarian disease, hyperlipidaemia, hypertension and atherosclerosis. The pathophysiology of insulin resistance involves a complex network of signalling pathways, activated by the insulin receptor, which regulates intermediary metabolism and its organization in cells. But recent studies have shown that numerous other hormones and signalling events attenuate insulin action, and are important in type 2 diabetes.

Links

PubMed Online version:10.1038/414799a

Keywords

Adipose Tissue/metabolism; Animals; Cytoskeletal Proteins/metabolism; Diabetes Mellitus, Type 2/metabolism; Glucose/metabolism; Insulin/metabolism; Insulin Resistance; Lipid Metabolism; Mice; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-cbl; Receptor, Insulin/metabolism; Signal Transduction; Ubiquitin-Protein Ligases

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:GLUT4

involved_in

GO:0046323: glucose import

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:INS

involved_in

GO:0050995: negative regulation of lipid catabolic process

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:INS

involved_in

GO:0046889: positive regulation of lipid biosynthetic process

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:INS

involved_in

GO:0030307: positive regulation of cell growth

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:INS

involved_in

GO:0045597: positive regulation of cell differentiation

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:INS

involved_in

GO:0045721: negative regulation of gluconeogenesis

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PTN1

involved_in

GO:0046627: negative regulation of insulin receptor signaling pathway

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete


See also

References

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