HUMAN:PTC1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTCH1 (synonyms: PTCH)
Protein Name(s)	Protein patched homolog 1 PTC PTC1
External Links
UniProt	Q13635
EMBL	U59464 U43148 AL161729 AL161729 AB189436 AB189437 AB189438 AB189439 AB189440 BC043542 AB239329
CCDS	CCDS43851.1 CCDS47995.1 CCDS47996.1 CCDS6714.1
RefSeq	NP_000255.2 NP_001077071.1 NP_001077072.1 NP_001077073.1 NP_001077074.1 NP_001077075.1 NP_001077076.1 XP_005252159.1
UniGene	Hs.494538
ProteinModelPortal	Q13635
BioGrid	111699
DIP	DIP-44940N
IntAct	Q13635
MINT	MINT-1543380
STRING	9606.ENSP00000332353
PhosphoSite	Q13635
DMDM	160415977
PaxDb	Q13635
PRIDE	Q13635
DNASU	5727
Ensembl	ENST00000331920 ENST00000375274 ENST00000418258 ENST00000421141 ENST00000429896 ENST00000430669 ENST00000437951 ENST00000468211 ENST00000546820 ENST00000547672 ENST00000551845 ENST00000553011
GeneID	5727
KEGG	hsa:5727
UCSC	uc004avk.4 uc004avm.4 uc010mrr.3
CTD	5727
GeneCards	GC09M098205
GeneReviews	PTCH1
HGNC	HGNC:9585
HPA	CAB013717
MIM	109400 601309 605462 610828
neXtProt	NX_Q13635
Orphanet	93925 377 93924 280200 93926 77301 220386 280195
PharmGKB	PA33937
eggNOG	NOG313603
GeneTree	ENSGT00760000119174
HOVERGEN	HBG003801
InParanoid	Q13635
KO	K06225
OMA	LQRPSYC
OrthoDB	EOG7HMS06
PhylomeDB	Q13635
TreeFam	TF106489
Reactome	REACT_18372 REACT_267634
SignaLink	Q13635
ChiTaRS	PTCH1
GeneWiki	PTCH1
GenomeRNAi	5727
NextBio	22266
PRO	PR:Q13635
Proteomes	UP000005640
Bgee	Q13635
CleanEx	HS_PTCH1
ExpressionAtlas	Q13635
Genevestigator	Q13635
GO	GO:0044295 GO:0005901 GO:0044294 GO:0016021 GO:0043231 GO:0030496 GO:0048471 GO:0005886 GO:0014069 GO:0072372 GO:0015485 GO:0030332 GO:0097108 GO:0008158 GO:0008201 GO:0005119 GO:0007420 GO:0001658 GO:0061005 GO:0072203 GO:0071397 GO:0009953 GO:0030326 GO:0048568 GO:0008544 GO:0042593 GO:0003007 GO:0035137 GO:0001701 GO:0043616 GO:0035108 GO:0060603 GO:0060644 GO:0051782 GO:0050680 GO:0040015 GO:0045668 GO:0043433 GO:0045879 GO:0000122 GO:0021997 GO:0001843 GO:0021532 GO:0009887 GO:0060037 GO:0010875 GO:0016485 GO:0072661 GO:0007346 GO:0032880 GO:0008589 GO:0072001 GO:0010157 GO:0042493 GO:0032355 GO:0009612 GO:0032526 GO:0007224 GO:0060831 GO:0061053 GO:0021522
InterPro	IPR003392 IPR000731 IPR004766
Pfam	PF02460
TIGRFAMs	TIGR00918
PROSITE	PS50156

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005887	integral to plasma membrane		ECO:0000304			C		Source: ProtInc	Missing: reference
enables	GO:0097108	hedgehog family protein binding	PMID:9811851^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97812	F		Seeded From UniProt	complete
enables	GO:0097108	hedgehog family protein binding	PMID:9811851^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61488	F		Seeded From UniProt	complete
enables	GO:0097108	hedgehog family protein binding	PMID:9811851^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q62226	F		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:11278759^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	transports_or_maintains_localization_of:(UniProtKB:Q99835)	Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	PMID:11278759^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	PMID:8681379^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	PMID:8981943^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	PMID:8681379^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:11278759^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
involved_in	GO:0045668	negative regulation of osteoblast differentiation	PMID:16229683^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P08151)	Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:16229683^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P08151)	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:11278759^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	PMID:8681379^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:11331587^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14635	F		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:11331587^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13350	F		Seeded From UniProt	complete
involved_in	GO:0021997	neural plate axis specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
involved_in	GO:0021532	neural tube patterning	PMID:8681379^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:21931618^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:21931618^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:11278759^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12635140^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11278759^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005794	Golgi apparatus	PMID:11278759^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005119	smoothened binding	PMID:9811851^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99835	F		Seeded From UniProt	complete
enables	GO:0005119	smoothened binding	PMID:11278759^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99835	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16229683^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072001	renal system development	PMID:17850284^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040015	negative regulation of multicellular organism growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
involved_in	GO:0008589	regulation of smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:17850284^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61115	P		Seeded From UniProt	complete
enables	GO:0097108	hedgehog family protein binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000847539 UniProtKB:Q13635 UniProtKB:Q9Y6C5	F		Seeded From UniProt	complete
enables	GO:0008158	hedgehog receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003892 PANTHER:PTN000847539	F		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003892 MGI:MGI:105373 PANTHER:PTN000847539 UniProtKB:Q13635	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003892 MGI:MGI:105373 PANTHER:PTN002916954 UniProtKB:Q13635	C		Seeded From UniProt	complete
enables	GO:0005119	smoothened binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000847539 UniProtKB:Q13635 UniProtKB:Q9Y6C5	F		Seeded From UniProt	complete
involved_in	GO:0072203	cell proliferation involved in metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0071397	cellular response to cholesterol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0061053	somite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0061005	cell differentiation involved in kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0060644	mammary gland epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0060603	mammary gland duct morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0051782	negative regulation of cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0045606	positive regulation of epidermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	F		Seeded From UniProt	complete
involved_in	GO:0043616	keratinocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0040015	negative regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0035137	hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	C		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	F		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0021997	neural plate axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0021904	dorsal/ventral neural tube patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0021522	spinal cord motor neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0010157	response to chlorate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0009957	epidermal cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	F		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	C		Seeded From UniProt	complete
enables	GO:0005113	patched binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	F		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0001841	neural tube formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0001709	cell fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61115 ensembl:ENSMUSP00000021921	P		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	C		Seeded From UniProt	complete
part_of	GO:0044294	dendritic growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	C		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6UY90 ensembl:ENSRNOP00000026287	C		Seeded From UniProt	complete
enables	GO:0008158	hedgehog receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004766	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003392 InterPro:IPR004766	C		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	PMID:11001584^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	Reactome:R-HSA-5635865 Reactome:R-HSA-5632677 Reactome:R-HSA-5632652 Reactome:R-HSA-5632649 Reactome:R-HSA-5612510	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-5632677	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Carpenter, D et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc. Natl. Acad. Sci. U.S.A. 95 13630-4 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Karpen, HE et al. (2001) The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J. Biol. Chem. 276 19503-11 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hahn, H et al. (1996) Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85 841-51 PubMed GONUTS page
↑ Wicking, C et al. (1997) Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. Am. J. Hum. Genet. 60 21-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Rahnama, F et al. (2006) Inhibition of GLI1 gene activation by Patched1. Biochem. J. 394 19-26 PubMed GONUTS page
↑ ^6.0 ^6.1 Barnes, EA et al. (2001) Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J. 20 2214-23 PubMed GONUTS page
↑ ^7.0 ^7.1 Bidet, M et al. (2011) The hedgehog receptor patched is involved in cholesterol transport. PLoS ONE 6 e23834 PubMed GONUTS page
↑ Stewart, GA et al. (2003) Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. J. Pathol. 199 488-95 PubMed GONUTS page
↑ ^9.0 ^9.1 Jenkins, D et al. (2007) Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J. Anat. 211 620-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Villavicencio, EH et al. (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67 1047-54 PubMed GONUTS page

[PMID:9811851-1] 1.0 ^1.1 ^1.2 ^1.3 Carpenter, D et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc. Natl. Acad. Sci. U.S.A. 95 13630-4 PubMed GONUTS page

[PMID:11278759-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Karpen, HE et al. (2001) The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J. Biol. Chem. 276 19503-11 PubMed GONUTS page

[PMID:8681379-3] 3.0 ^3.1 ^3.2 ^3.3 Hahn, H et al. (1996) Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85 841-51 PubMed GONUTS page

[PMID:8981943-4] Wicking, C et al. (1997) Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. Am. J. Hum. Genet. 60 21-6 PubMed GONUTS page

[PMID:16229683-5] 5.0 ^5.1 ^5.2 Rahnama, F et al. (2006) Inhibition of GLI1 gene activation by Patched1. Biochem. J. 394 19-26 PubMed GONUTS page

[PMID:11331587-6] 6.0 ^6.1 Barnes, EA et al. (2001) Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J. 20 2214-23 PubMed GONUTS page

[PMID:21931618-7] 7.0 ^7.1 Bidet, M et al. (2011) The hedgehog receptor patched is involved in cholesterol transport. PLoS ONE 6 e23834 PubMed GONUTS page

[PMID:12635140-8] Stewart, GA et al. (2003) Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. J. Pathol. 199 488-95 PubMed GONUTS page

[PMID:17850284-9] 9.0 ^9.1 Jenkins, D et al. (2007) Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J. Anat. 211 620-9 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11001584-11] Villavicencio, EH et al. (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67 1047-54 PubMed GONUTS page

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