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HUMAN:PRDX4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PRDX4
Protein Name(s) Peroxiredoxin-4

Antioxidant enzyme AOE372 AOE37-2 Peroxiredoxin IV Prx-IV Thioredoxin peroxidase AO372 Thioredoxin-dependent peroxide reductase A0372

External Links
UniProt Q13162
EMBL U25182
CR541668
CR541705
BC003609
BC007107
BC016770
CCDS CCDS14206.1
PIR G01790
RefSeq NP_006397.1
UniGene Hs.83383
PDB 2PN8
3TJB
3TJF
3TJG
3TJJ
3TJK
3TKP
3TKQ
3TKR
3TKS
PDBsum 2PN8
3TJB
3TJF
3TJG
3TJJ
3TJK
3TKP
3TKQ
3TKR
3TKS
ProteinModelPortal Q13162
SMR Q13162
BioGrid 115800
IntAct Q13162
MINT MINT-3027265
STRING 9606.ENSP00000368646
PeroxiBase 4530
PhosphoSite Q13162
DMDM 3024727
OGP Q13162
REPRODUCTION-2DPAGE IPI00011937
UCD-2DPAGE Q13162
MaxQB Q13162
PaxDb Q13162
PeptideAtlas Q13162
PRIDE Q13162
DNASU 10549
Ensembl ENST00000379341
GeneID 10549
KEGG hsa:10549
UCSC uc004dam.3
CTD 10549
GeneCards GC0XP023592
HGNC HGNC:17169
HPA CAB008659
CAB027389
CAB047362
MIM 300927
neXtProt NX_Q13162
PharmGKB PA33725
eggNOG COG0450
HOGENOM HOG000022343
HOVERGEN HBG000286
InParanoid Q13162
KO K03386
OMA FHKGEFV
PhylomeDB Q13162
TreeFam TF105181
ChiTaRS PRDX4
EvolutionaryTrace Q13162
GeneWiki PRDX4
GenomeRNAi 10549
NextBio 40013
PRO PR:Q13162
Proteomes UP000005640
Bgee Q13162
CleanEx HS_PRDX4
ExpressionAtlas Q13162
Genevestigator Q13162
GO GO:0005829
GO:0005615
GO:0070062
GO:0005739
GO:0005634
GO:0005790
GO:0008379
GO:0019471
GO:0045454
GO:0030198
GO:0007252
GO:0008584
GO:2000255
GO:0022417
GO:0072593
GO:0007283
Gene3D 3.40.30.10
InterPro IPR000866
IPR024706
IPR019479
IPR012336
Pfam PF10417
PF00578
PIRSF PIRSF000239
SUPFAM SSF52833
PROSITE PS51352

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004601

peroxidase activity

PMID:25656995[1]

ECO:0000314

F

Fig.1 pathway of Peroxiredoxins shown

complete
CACAO 10637

part_of

GO:0070062

extracellular exosome

PMID:19199708[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040309
MGI:MGI:1859815
PANTHER:PTN000073874
PomBase:SPCC576.03c
SGD:S000002861
SGD:S000004490
UniProtKB:P9WQB7

P

Seeded From UniProt

complete

involved_in

GO:0042744

hydrogen peroxide catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189947
FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:109486
PANTHER:PTN000073874
PomBase:SPCC576.03c
UniProtKB:Q06830
UniProtKB:Q6ER94

P

Seeded From UniProt

complete

enables

GO:0008379

thioredoxin peroxidase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189947
FB:FBgn0040308
FB:FBgn0040309
PANTHER:PTN000073874
PomBase:SPCC576.03c
SGD:S000002861
SGD:S000004490
UniProtKB:P32119
UniProtKB:Q06830
UniProtKB:Q8I5Q6
UniProtKB:Q8IL80

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:99523
PANTHER:PTN000073874
RGD:3838
RGD:620039
UniProtKB:P32119
UniProtKB:Q8I5Q6
UniProtKB:Q8IL80

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11384
FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:1859815
PANTHER:PTN000073874
RGD:3838
RGD:620039
SGD:S000004490
UniProtKB:Q8IL80

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040308
MGI:MGI:1859815
PANTHER:PTN000841180

C

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016209

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0051920

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008379

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008379

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016209

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004601

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0051920

P

Seeded From UniProt

complete

involved_in

GO:2000255

negative regulation of male germ cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

involved_in

GO:0072593

reactive oxygen species metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

F

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

involved_in

GO:0022417

protein maturation by protein folding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

involved_in

GO:0019471

4-hydroxyproline metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

involved_in

GO:0008584

male gonad development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08807
ensembl:ENSMUSP00000026328

C

Seeded From UniProt

complete

part_of

GO:0005790

smooth endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0V5
ensembl:ENSRNOP00000005014

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z0V5
ensembl:ENSRNOP00000005014

C

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013766

P

Seeded From UniProt

complete

enables

GO:0051920

peroxiredoxin activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019479

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866
InterPro:IPR019479

P

Seeded From UniProt

complete

enables

GO:0051920

peroxiredoxin activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.11.1.15

F

Seeded From UniProt

complete

enables

GO:0008379

thioredoxin peroxidase activity

PMID:9388242[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007252

I-kappaB phosphorylation

PMID:9388242[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1904813

ficolin-1-rich granule lumen

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6800434
Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0575

F

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0049

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Fujii, J et al. (2015) Physiological and pathological views of peroxiredoxin 4. Free Radic. Biol. Med. 83 373-9 PubMed GONUTS page
  2. ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  3. ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 Jin, DY et al. (1997) Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. J. Biol. Chem. 272 30952-61 PubMed GONUTS page
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