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HUMAN:POLK
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | POLK (synonyms: DINB1) | |
Protein Name(s) | DNA polymerase kappa
DINB protein DINP | |
External Links | ||
UniProt | Q9UBT6 | |
EMBL | AB027564 AF163570 AY769929 AY769931 AY769930 AY769932 AF194973 AF315602 AF318313 AK091659 AK314610 AY273797 AC010245 AC026424 AC116341 CH471084 BC014955 BC050718 AB036934 AB036935 | |
CCDS | CCDS4030.1 | |
RefSeq | NP_057302.1 | |
UniGene | Hs.135756 | |
PDB | 1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 | |
PDBsum | 1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 | |
ProteinModelPortal | Q9UBT6 | |
SMR | Q9UBT6 | |
BioGrid | 119532 | |
IntAct | Q9UBT6 | |
BindingDB | Q9UBT6 | |
ChEMBL | CHEMBL5365 | |
PhosphoSite | Q9UBT6 | |
DMDM | 59798438 | |
MaxQB | Q9UBT6 | |
PaxDb | Q9UBT6 | |
PRIDE | Q9UBT6 | |
Ensembl | ENST00000241436 ENST00000504026 ENST00000508526 ENST00000509126 ENST00000510815 ENST00000515295 | |
GeneID | 51426 | |
KEGG | hsa:51426 | |
UCSC | uc003kdw.3 uc003keb.3 uc010izq.3 | |
CTD | 51426 | |
GeneCards | GC05P074843 | |
HGNC | HGNC:9183 | |
HPA | HPA057303 | |
MIM | 605650 | |
neXtProt | NX_Q9UBT6 | |
PharmGKB | PA33503 | |
eggNOG | COG0389 | |
GeneTree | ENSGT00530000062942 | |
HOVERGEN | HBG101212 | |
InParanoid | Q9UBT6 | |
KO | K03511 | |
OMA | NWPEDKR | |
OrthoDB | EOG73Z2SP | |
PhylomeDB | Q9UBT6 | |
TreeFam | TF314387 | |
EvolutionaryTrace | Q9UBT6 | |
GeneWiki | POLK | |
GenomeRNAi | 51426 | |
NextBio | 54977 | |
PRO | PR:Q9UBT6 | |
Proteomes | UP000005640 | |
Bgee | Q9UBT6 | |
ExpressionAtlas | Q9UBT6 | |
Genevestigator | Q9UBT6 | |
GO | GO:0005634 GO:0003684 GO:0003887 GO:0046872 GO:0006281 GO:0006260 GO:0006297 | |
Gene3D | 3.30.1490.100 | |
HAMAP | MF_01113 | |
InterPro | IPR017961 IPR001126 IPR017963 IPR022880 IPR024728 IPR006642 | |
Pfam | PF00817 PF11799 PF11798 | |
SMART | SM00734 | |
SUPFAM | SSF100879 | |
PROSITE | PS50173 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
colocalizes_with |
GO:0090734 |
site of DNA damage |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034644 |
cellular response to UV |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042276 |
error-prone translesion synthesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006297 |
nucleotide-excision repair, DNA gap filling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042276 |
error-prone translesion synthesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000117876 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019985 |
translesion synthesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG13141 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1349767 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003887 |
DNA-directed DNA polymerase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG13141 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0016604 |
nuclear body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QUG2 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9QUG2 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003887 |
DNA-directed DNA polymerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001126 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003887 |
DNA-directed DNA polymerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042276 |
error-prone translesion synthesis |
Reactome:R-HSA-5655862 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033683 |
nucleotide-excision repair, DNA incision |
Reactome:R-HSA-5696400 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019985 |
translesion synthesis |
Reactome:R-HSA-110313 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006297 |
nucleotide-excision repair, DNA gap filling |
Reactome:R-HSA-5696397 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006296 |
nucleotide-excision repair, DNA incision, 5'-to lesion |
Reactome:R-HSA-5690988 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006283 |
transcription-coupled nucleotide-excision repair |
Reactome:R-HSA-6781827 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6782227 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003887 |
DNA-directed DNA polymerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006260 |
DNA replication |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071897 |
DNA biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Xiang, Y et al. (2017) RNA mA methylation regulates the ultraviolet-induced DNA damage response. Nature 543 573-576 PubMed GONUTS page
- ↑ Ogi, T et al. (2010) Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol. Cell 37 714-27 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Ogi, T et al. (1999) Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB. Genes Cells 4 607-18 PubMed GONUTS page
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