HUMAN:PKD1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PKD1
Protein Name(s)	Polycystin-1 Autosomal dominant polycystic kidney disease 1 protein
External Links
UniProt	P98161
EMBL	U24497 L33243 L43619 L43601 L43602 L43604 L43605 L43610 L43617 L43618 AC093513 AC009065
CCDS	CCDS32369.1 CCDS45385.1
PIR	A38971
RefSeq	NP_000287.3 NP_001009944.2
UniGene	Hs.75813
PDB	1B4R
PDBsum	1B4R
ProteinModelPortal	P98161
SMR	P98161
BioGrid	111327
DIP	DIP-52317N
IntAct	P98161
MINT	MINT-1199187
STRING	9606.ENSP00000262304
ChEMBL	CHEMBL5772
MEROPS	T06.001
TCDB	1.A.5.1.1
PhosphoSite	P98161
DMDM	292495072
MaxQB	P98161
PaxDb	P98161
PRIDE	P98161
Ensembl	ENST00000262304 ENST00000423118
GeneID	5310
KEGG	hsa:5310
UCSC	uc002cos.1 uc002cot.1
CTD	5310
GeneCards	GC16M002138
GeneReviews	PKD1
H-InvDB	HIX0173395 HIX0202314
HGNC	HGNC:9008
HPA	CAB046448
MIM	173900 601313
neXtProt	NX_P98161
Orphanet	730 88924
PharmGKB	PA35521
eggNOG	COG3291
GeneTree	ENSGT00700000104221
HOGENOM	HOG000168445
HOVERGEN	HBG049412
InParanoid	P98161
KO	K04985
OMA	GQCNTDL
OrthoDB	EOG76X5Z6
PhylomeDB	P98161
TreeFam	TF316484
SignaLink	P98161
EvolutionaryTrace	P98161
GeneWiki	PKD1
GenomeRNAi	5310
NextBio	20530
PRO	PR:P98161
Proteomes	UP000005640
Bgee	P98161
CleanEx	HS_PKD1
ExpressionAtlas	P98161
Genevestigator	P98161
GO	GO:0016323 GO:0005929 GO:0005737 GO:0070062 GO:0005794 GO:0016021 GO:0005887 GO:0016328 GO:0031512 GO:0005634 GO:0005886 GO:0002133 GO:0005262 GO:0030246 GO:0044325 GO:0019904 GO:0019901 GO:0009653 GO:0048754 GO:0070588 GO:0007161 GO:0001502 GO:0051216 GO:0007050 GO:0007160 GO:0042994 GO:0050982 GO:0048565 GO:0001892 GO:0048806 GO:0007507 GO:0007156 GO:0001701 GO:0007259 GO:0001822 GO:0001889 GO:0060428 GO:0072177 GO:0072164 GO:0072218 GO:0072205 GO:0072287 GO:0072237 GO:0021915 GO:0007218 GO:0006807 GO:0018105 GO:0060674 GO:0031659 GO:0007204 GO:0032092 GO:0045944 GO:0006611 GO:0060236 GO:0061136 GO:0034405 GO:0016337 GO:0043588 GO:0021510
Gene3D	2.60.40.670 2.60.60.20 3.10.100.10
InterPro	IPR001304 IPR016186 IPR016187 IPR000483 IPR000203 IPR001611 IPR003591 IPR008976 IPR000372 IPR000434 IPR022409 IPR002859 IPR013122 IPR000601 IPR001024 IPR006228 IPR014010 IPR002889 IPR013994
Pfam	PF01825 PF00059 PF13855 PF01462 PF00801 PF08016 PF01477 PF02010 PF01822
PRINTS	PR00500
SMART	SM00034 SM00303 SM00308 SM00369 SM00082 SM00013 SM00089 SM00321
SUPFAM	SSF49299 SSF49723 SSF56436
TIGRFAMs	TIGR00864
PROSITE	PS50041 PS50221 PS51450 PS50093 PS50095 PS51111 PS51212

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019887	protein kinase regulator activity	PMID:23148218^[1]	ECO:0000314			F		Figure 2 shows that depletion of PKD1 from cells increased their ability to migrate. Data suggests that inhibition of endogenous basal PKD1 activity is a mechanism of how NRG induces cell migration.	complete CACAO 5877
	GO:0004672	protein kinase activity	PMID:23028574^[2]	ECO:0000314			F		Figure 2 shows that '% residual PKD1 kinase activity calculated based on the total kinase activity measured in the absence of inhibitors (DMSO).'	complete CACAO 5893
	GO:0004672	protein kinase activity	PMID:23028574^[2]	ECO:0000314			F		Table 1 shows 'PKD1 selective inhibitors with little or no inhibitory activity for PKCα, PKCδ or CAMKIIα.'	complete CACAO 5894
part_of	GO:0005887	integral component of plasma membrane	PMID:30093605^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	PMID:30093605^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0030155	regulation of cell adhesion	PMID:25947155^[4]	ECO:0000315			P		Figure 3 shows Polycystin-1 regulates cell adhesion to the substrate.	complete CACAO 11837
contributes_to	GO:0005262	calcium channel activity	PMID:27214281^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0198738	cell-cell signaling by wnt	PMID:27214281^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	PMID:27214281^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	PMID:27214281^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	C		Seeded From UniProt	complete
involved_in	GO:2000045	regulation of G1/S transition of mitotic cell cycle	PMID:16311606^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	PMID:30093605^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:15326289^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0060674	placenta blood vessel development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
involved_in	GO:0050982	detection of mechanical stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16311606^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:9192675^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
involved_in	GO:0042994	cytoplasmic sequestering of transcription factor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:16311606^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:2000045)	Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:9171830^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13563	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:10770959^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10097141^[12]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	C		Seeded From UniProt	complete
part_of	GO:0002133	polycystin complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	C		Seeded From UniProt	complete
involved_in	GO:0001892	embryonic placenta development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08852	P		Seeded From UniProt	complete
involved_in	GO:0072287	metanephric distal tubule morphogenesis	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072237	metanephric proximal tubule development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072218	metanephric ascending thin limb development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072205	metanephric collecting duct development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072177	mesonephric duct development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072164	mesonephric tubule development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060428	lung epithelium development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048806	genitalia development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	PMID:12482949^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043588	skin development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(UBERON:0002240)\|occurs_in:(CL:0000530)	Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17980165^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P51817	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:11891195^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061136	regulation of proteasomal protein catabolic process	PMID:23001567^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:28154160^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23001567^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD3 ensembl:ENSRNOP00000015092	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD3 ensembl:ENSRNOP00000015092	C		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD3 ensembl:ENSRNOP00000015092	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD3 ensembl:ENSRNOP00000015092	C		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0061136	regulation of proteasomal protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0060674	placenta blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0060236	regulation of mitotic spindle organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0050982	detection of mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0042994	cytoplasmic sequestering of transcription factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0036303	lymph vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0034405	response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0006807	nitrogen compound metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	F		Seeded From UniProt	complete
part_of	GO:0002133	polycystin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	C		Seeded From UniProt	complete
involved_in	GO:0001892	embryonic placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08852 ensembl:ENSMUSP00000049296	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000434	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000434	C		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:9326937^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007161	calcium-independent cell-matrix adhesion	PMID:10861291^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	PMID:7663510^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PMID:10861291^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7663510^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	Reactome:R-HSA-5623527	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030660	Golgi-associated vesicle membrane	Reactome:R-HSA-5623527 Reactome:R-HSA-5623525 Reactome:R-HSA-5623524	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-5623525 Reactome:R-HSA-5623521 Reactome:R-HSA-5623519 Reactome:R-HSA-5623513 Reactome:R-HSA-5620921 Reactome:R-HSA-5620914	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Döppler, H et al. (2013) Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein. J. Biol. Chem. 288 455-65 PubMed GONUTS page
↑ ^2.0 ^2.1 Tandon, M et al. (2012) A targeted library screen reveals a new inhibitor scaffold for protein kinase D. PLoS ONE 7 e44653 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Su, Q et al. (2018) Structure of the human PKD1-PKD2 complex. Science 361 PubMed GONUTS page
↑ Castelli, M et al. (2015) Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration. BMC Cell Biol. 16 15 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kim, S et al. (2016) The polycystin complex mediates Wnt/Ca(2+) signalling. Nat. Cell Biol. 18 752-764 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Li, X et al. (2005) Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat. Cell Biol. 7 1202-12 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Pisitkun, T et al. (2004) Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U.S.A. 101 13368-73 PubMed GONUTS page
↑ Tsiokas, L et al. (1997) Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc. Natl. Acad. Sci. U.S.A. 94 6965-70 PubMed GONUTS page
↑ Qian, F et al. (1997) PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat. Genet. 16 179-83 PubMed GONUTS page
↑ Foggensteiner, L et al. (2000) Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. J. Am. Soc. Nephrol. 11 814-27 PubMed GONUTS page
↑ Tsiokas, L et al. (1999) Specific association of the gene product of PKD2 with the TRPC1 channel. Proc. Natl. Acad. Sci. U.S.A. 96 3934-9 PubMed GONUTS page
↑ ^13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 ^13.13 Chauvet, V et al. (2002) Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development. Am. J. Pathol. 160 973-83 PubMed GONUTS page
↑ Qian, F et al. (2002) Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc. Natl. Acad. Sci. U.S.A. 99 16981-6 PubMed GONUTS page
↑ Li, X et al. (2008) Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. Biochim. Biophys. Acta 1782 1-9 PubMed GONUTS page
↑ ^16.0 ^16.1 Foy, RL et al. (2012) Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum. Mol. Genet. 21 5456-71 PubMed GONUTS page
↑ Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
↑ Lu, W et al. (1997) Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat. Genet. 17 179-81 PubMed GONUTS page
↑ ^19.0 ^19.1 Ibraghimov-Beskrovnaya, O et al. (2000) Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1. Hum. Mol. Genet. 9 1641-9 PubMed GONUTS page
↑ ^20.0 ^20.1 Hughes, J et al. (1995) The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. Nat. Genet. 10 151-60 PubMed GONUTS page

[PMID:23148218-1] Döppler, H et al. (2013) Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein. J. Biol. Chem. 288 455-65 PubMed GONUTS page

[PMID:23028574-2] 2.0 ^2.1 Tandon, M et al. (2012) A targeted library screen reveals a new inhibitor scaffold for protein kinase D. PLoS ONE 7 e44653 PubMed GONUTS page

[PMID:30093605-3] 3.0 ^3.1 ^3.2 Su, Q et al. (2018) Structure of the human PKD1-PKD2 complex. Science 361 PubMed GONUTS page

[PMID:25947155-4] Castelli, M et al. (2015) Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration. BMC Cell Biol. 16 15 PubMed GONUTS page

[PMID:27214281-5] 5.0 ^5.1 ^5.2 ^5.3 Kim, S et al. (2016) The polycystin complex mediates Wnt/Ca(2+) signalling. Nat. Cell Biol. 18 752-764 PubMed GONUTS page

[PMID:16311606-6] 6.0 ^6.1 ^6.2 Li, X et al. (2005) Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat. Cell Biol. 7 1202-12 PubMed GONUTS page

[PMID:19056867-7] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:15326289-8] Pisitkun, T et al. (2004) Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U.S.A. 101 13368-73 PubMed GONUTS page

[PMID:9192675-9] Tsiokas, L et al. (1997) Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc. Natl. Acad. Sci. U.S.A. 94 6965-70 PubMed GONUTS page

[PMID:9171830-10] Qian, F et al. (1997) PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat. Genet. 16 179-83 PubMed GONUTS page

[PMID:10770959-11] Foggensteiner, L et al. (2000) Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. J. Am. Soc. Nephrol. 11 814-27 PubMed GONUTS page

[PMID:10097141-12] Tsiokas, L et al. (1999) Specific association of the gene product of PKD2 with the TRPC1 channel. Proc. Natl. Acad. Sci. U.S.A. 96 3934-9 PubMed GONUTS page

[PMID:11891195-13] 13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 ^13.13 Chauvet, V et al. (2002) Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development. Am. J. Pathol. 160 973-83 PubMed GONUTS page

[PMID:12482949-14] Qian, F et al. (2002) Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc. Natl. Acad. Sci. U.S.A. 99 16981-6 PubMed GONUTS page

[PMID:17980165-15] Li, X et al. (2008) Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. Biochim. Biophys. Acta 1782 1-9 PubMed GONUTS page

[PMID:23001567-16] 16.0 ^16.1 Foy, RL et al. (2012) Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum. Mol. Genet. 21 5456-71 PubMed GONUTS page

[PMID:28154160-17] Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page

[PMID:9326937-18] Lu, W et al. (1997) Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat. Genet. 17 179-81 PubMed GONUTS page

[PMID:10861291-19] 19.0 ^19.1 Ibraghimov-Beskrovnaya, O et al. (2000) Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1. Hum. Mol. Genet. 9 1641-9 PubMed GONUTS page

[PMID:7663510-20] 20.0 ^20.1 Hughes, J et al. (1995) The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. Nat. Genet. 10 151-60 PubMed GONUTS page

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