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PMID:25947155
| Citation |
Castelli, M, De Pascalis, C, Distefano, G, Ducano, N, Oldani, A, Lanzetti, L and Boletta, A (2015) Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration. BMC Cell Biol. 16:15 |
|---|---|
| Abstract |
Polycystin-1 (PC-1) is a large plasma membrane receptor, encoded by the PKD1 gene, which is mutated in most cases of Autosomal Dominant Polycystic Kidney Disease (ADPKD). The disease is characterized by renal cysts. The precise function of PC-1 remains elusive, although several studies suggest that it can regulate the cellular shape in response to external stimuli. We and others reported that PC-1 regulates the actin cytoskeleton and cell migration. |
| Links |
PubMed PMC4437554 Online version:10.1186/s12860-015-0059-3 |
| Keywords |
Actin Cytoskeleton/metabolism; Animals; Cell Adhesion; Cell Line; Cell Movement; Dogs; Fluorescence Recovery After Photobleaching; Focal Adhesion Protein-Tyrosine Kinases/metabolism; Focal Adhesions/metabolism; Madin Darby Canine Kidney Cells; Mice; Microtubules/metabolism; RNA Interference; RNA, Small Interfering/metabolism; TRPP Cation Channels/antagonists & inhibitors; TRPP Cation Channels/genetics; TRPP Cation Channels/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0030155: regulation of cell adhesion |
ECO:0000315: |
P |
Figure 3 shows Polycystin-1 regulates cell adhesion to the substrate. |
complete | ||||
Notes
See also
References
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