HUMAN:PIAS3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PIAS3
Protein Name(s)	E3 SUMO-protein ligase PIAS3 Protein inhibitor of activated STAT protein 3
External Links
UniProt	Q9Y6X2
EMBL	AB021868 BC001154 BC030556
CCDS	CCDS72866.1
PIR	T34525
RefSeq	NP_006090.2
UniGene	Hs.435761
PDB	4MVT
PDBsum	4MVT
ProteinModelPortal	Q9Y6X2
SMR	Q9Y6X2
BioGrid	115673
DIP	DIP-5969N
IntAct	Q9Y6X2
MINT	MINT-149343
STRING	9606.ENSP00000376765
PhosphoSite	Q9Y6X2
DMDM	56405390
MaxQB	Q9Y6X2
PaxDb	Q9Y6X2
PRIDE	Q9Y6X2
DNASU	10401
Ensembl	ENST00000393045
GeneID	10401
KEGG	hsa:10401
UCSC	uc001eoc.1
CTD	10401
GeneCards	GC01P145575
HGNC	HGNC:16861
MIM	605987
neXtProt	NX_Q9Y6X2
PharmGKB	PA134989011
eggNOG	NOG125513
GeneTree	ENSGT00550000074410
HOGENOM	HOG000230594
HOVERGEN	HBG053598
InParanoid	Q9Y6X2
KO	K16064
OMA	GELKHMV
PhylomeDB	Q9Y6X2
TreeFam	TF323787
SignaLink	Q9Y6X2
UniPathway	UPA00886
ChiTaRS	PIAS3
GeneWiki	PIAS3
GenomeRNAi	10401
NextBio	39416
PRO	PR:Q9Y6X2
Proteomes	UP000005640
Bgee	Q9Y6X2
CleanEx	HS_PIAS3
ExpressionAtlas	Q9Y6X2
Genevestigator	Q9Y6X2
GO	GO:0005737 GO:0030425 GO:0005634 GO:0045202 GO:0019899 GO:0003676 GO:0015459 GO:0008022 GO:0019789 GO:0008270 GO:0010628 GO:0045838 GO:0033235 GO:0016925 GO:0006355 GO:0009725 GO:0006351
Gene3D	1.10.720.30
InterPro	IPR027226 IPR023321 IPR003034 IPR004181
PANTHER	PTHR10782:SF10
Pfam	PF14324 PF02891
SMART	SM00513
PROSITE	PS51466 PS50800 PS51044

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005515	protein binding	PMID:17565989^[1]	ECO:0000021		UniProtKB:P18846	F	Figure.3	complete
	GO:0045449	regulation of transcription	PMID:17565989^[1]	ECO:0000315			P	figure 4	complete
	GO:0010628	positive regulation of gene expression	PMID:17565989^[1]	ECO:0000315			P	figure 7	complete
involved_in	GO:0033234	negative regulation of protein sumoylation	PMID:24651376^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033235	positive regulation of protein sumoylation	PMID:21965678^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033235	positive regulation of protein sumoylation	PMID:17696781^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:17087506^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35520	F	Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYE3	P	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:14715251^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15911	F	Seeded From UniProt	complete
enables	GO:0019789	SUMO transferase activity	PMID:15507434^[7]	ECO:0000269	experimental evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071847	TNFSF11-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54714 ensembl:ENSMUSP00000069259	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54714 ensembl:ENSMUSP00000069259	P	Seeded From UniProt	complete
involved_in	GO:0045671	negative regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54714 ensembl:ENSMUSP00000069259	P	Seeded From UniProt	complete
enables	GO:0019789	SUMO transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54714 ensembl:ENSMUSP00000069259	F	Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54714 ensembl:ENSMUSP00000069259	P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54714 ensembl:ENSMUSP00000069259	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54714 ensembl:ENSMUSP00000069259	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54714 ensembl:ENSMUSP00000069259	C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54714 ensembl:ENSMUSP00000069259	P	Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70260 ensembl:ENSRNOP00000028814	F	Seeded From UniProt	complete
involved_in	GO:0045838	positive regulation of membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70260 ensembl:ENSRNOP00000028814	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70260 ensembl:ENSRNOP00000028814	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70260 ensembl:ENSRNOP00000028814	C	Seeded From UniProt	complete
enables	GO:0015459	potassium channel regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70260 ensembl:ENSRNOP00000028814	F	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70260 ensembl:ENSRNOP00000028814	P	Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70260 ensembl:ENSRNOP00000028814	P	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70260 ensembl:ENSRNOP00000028814	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70260 ensembl:ENSRNOP00000028814	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004181	F	Seeded From UniProt	complete
enables	GO:0019789	SUMO transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027226	F	Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	Reactome:R-HSA-4655355 Reactome:R-HSA-3465545 Reactome:R-HSA-3232162	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4755536 Reactome:R-HSA-4719436 Reactome:R-HSA-4719413 Reactome:R-HSA-4655355 Reactome:R-HSA-4546386 Reactome:R-HSA-4546385 Reactome:R-HSA-4341073 Reactome:R-HSA-4090408 Reactome:R-HSA-4090288 Reactome:R-HSA-4086036 Reactome:R-HSA-3465545 Reactome:R-HSA-3232162	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C	Seeded From UniProt	complete
involved_in	GO:0016925	protein sumoylation	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00886	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Iwasaki, K et al. (2007) PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. J. Biol. Chem. 282 22335-43 PubMed GONUTS page
↑ Sun, X et al. (2014) Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells. PLoS ONE 9 e92746 PubMed GONUTS page
↑ Cong, L et al. (2011) SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. J. Biol. Chem. 286 43793-808 PubMed GONUTS page
↑ Jambunathan, S & Fontes, JD (2007) Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. Biol. Chem. 388 965-72 PubMed GONUTS page
↑ Kabil, O et al. (2006) Human cystathionine beta-synthase is a target for sumoylation. Biochemistry 45 13528-36 PubMed GONUTS page
↑ Nojiri, S et al. (2004) ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. Biochem. Biophys. Res. Commun. 314 97-103 PubMed GONUTS page
↑ Miller, AJ et al. (2005) Sumoylation of MITF and its related family members TFE3 and TFEB. J. Biol. Chem. 280 146-55 PubMed GONUTS page

[PMID:17565989-1] 1.0 ^1.1 ^1.2 Iwasaki, K et al. (2007) PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. J. Biol. Chem. 282 22335-43 PubMed GONUTS page

[PMID:24651376-2] Sun, X et al. (2014) Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells. PLoS ONE 9 e92746 PubMed GONUTS page

[PMID:21965678-3] Cong, L et al. (2011) SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. J. Biol. Chem. 286 43793-808 PubMed GONUTS page

[PMID:17696781-4] Jambunathan, S & Fontes, JD (2007) Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. Biol. Chem. 388 965-72 PubMed GONUTS page

[PMID:17087506-5] Kabil, O et al. (2006) Human cystathionine beta-synthase is a target for sumoylation. Biochemistry 45 13528-36 PubMed GONUTS page

[PMID:14715251-6] Nojiri, S et al. (2004) ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. Biochem. Biophys. Res. Commun. 314 97-103 PubMed GONUTS page

[PMID:15507434-7] Miller, AJ et al. (2005) Sumoylation of MITF and its related family members TFE3 and TFEB. J. Biol. Chem. 280 146-55 PubMed GONUTS page

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HUMAN:PIAS3

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