HUMAN:PI3R6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PIK3R6 (synonyms: C17orf38)
Protein Name(s)	Phosphoinositide 3-kinase regulatory subunit 6 Phosphoinositide 3-kinase gamma adapter protein of 87 kDa p84 PI3K adapter protein p84 PIKAP p87 PI3K adapter protein p87PIKAP
External Links
UniProt	Q5UE93
EMBL	AY753192 AC003695 AC009451 AL833037
CCDS	CCDS73985.1
RefSeq	NP_001010855.1
UniGene	Hs.255809
ProteinModelPortal	Q5UE93
IntAct	Q5UE93
STRING	9606.ENSP00000308352
PhosphoSite	Q5UE93
DMDM	74746772
PaxDb	Q5UE93
PRIDE	Q5UE93
DNASU	146850
Ensembl	ENST00000614407 ENST00000619866
GeneID	146850
KEGG	hsa:146850
UCSC	uc002glq.1
CTD	146850
GeneCards	GC17M008706
HGNC	HGNC:27101
HPA	HPA023077
MIM	611462
neXtProt	NX_Q5UE93
PharmGKB	PA162399570
eggNOG	NOG28373
GeneTree	ENSGT00530000063753
HOVERGEN	HBG080761
InParanoid	Q5UE93
PhylomeDB	Q5UE93
BioCyc	MetaCyc:ENSG00000174083-MONOMER
Reactome	REACT_121025 REACT_1695 REACT_19290
GenomeRNAi	146850
NextBio	85475
PRO	PR:Q5UE93
Proteomes	UP000005640
CleanEx	HS_PIK3R6
ExpressionAtlas	Q5UE93
Genevestigator	Q5UE93
GO	GO:0005829 GO:0016020 GO:0005944 GO:0046935 GO:0046934 GO:0001525 GO:0007596 GO:0007186 GO:0006661 GO:0006644 GO:0030168 GO:0045766 GO:0043406 GO:0043551 GO:0044281
InterPro	IPR019522
Pfam	PF10486

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042269	regulation of natural killer cell mediated cytotoxicity	PMID:11062502^[1]	ECO:0000314			P	Figs 1D and 1E show that inhibition of PI3K results in reduced NK cell cytoxicity	complete CACAO 6114
involved_in	GO:0042269	regulation of natural killer cell mediated cytotoxicity	PMID:11062502^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6Q4	F	Seeded From UniProt	complete
contributes_to	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6Q4	F	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21393242^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6Q4	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6Q4	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6Q4	P	Seeded From UniProt	complete
part_of	GO:0005944	phosphatidylinositol 3-kinase complex, class IB	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U6Q4	C	Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2144613 PANTHER:PTN001436768 RGD:1563261 UniProtKB:O02696	F	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2144613 PANTHER:PTN001436768 UniProtKB:O02696	P	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001436768 UniProtKB:O02696	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2144613 PANTHER:PTN001436768 UniProtKB:O02696	P	Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001436768 RGD:1563261	C	Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0046935	P	Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0046935	P	Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0046935	P	Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0046935	P	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0046934	P	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0046934	P	Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6Q4 ensembl:ENSMUSP00000052522	F	Seeded From UniProt	complete
enables	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6Q4 ensembl:ENSMUSP00000052522	F	Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6Q4 ensembl:ENSMUSP00000052522	P	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6Q4 ensembl:ENSMUSP00000052522	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6Q4 ensembl:ENSMUSP00000052522	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6Q4 ensembl:ENSMUSP00000052522	P	Seeded From UniProt	complete
part_of	GO:0005944	phosphatidylinositol 3-kinase complex, class IB	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q3U6Q4 ensembl:ENSMUSP00000052522	C	Seeded From UniProt	complete
part_of	GO:0005944	phosphatidylinositol 3-kinase complex, class IB	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019522	C	Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019522	F	Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	Reactome:R-HSA-1660499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-437162 Reactome:R-HSA-437118 Reactome:R-HSA-392300 Reactome:R-HSA-392295 Reactome:R-HSA-1676109 Reactome:R-HSA-1676048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Jiang, K et al. (2000) Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat. Immunol. 1 419-25 PubMed GONUTS page
↑ Wilson, LS et al. (2011) A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. J. Biol. Chem. 286 16285-96 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11062502-1] 1.0 ^1.1 Jiang, K et al. (2000) Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat. Immunol. 1 419-25 PubMed GONUTS page

[PMID:21393242-2] Wilson, LS et al. (2011) A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. J. Biol. Chem. 286 16285-96 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:PI3R6

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Annotations

Notes

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