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HUMAN:PFKAP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PFKP (synonyms: PFKF)
Protein Name(s) ATP-dependent 6-phosphofructokinase, platelet type (ECO:0000255 with HAMAP-Rule:MF_03184)

ATP-PFK (ECO:0000255 with HAMAP-Rule:MF_03184) PFK-P 6-phosphofructokinase type C Phosphofructo-1-kinase isozyme C PFK-C Phosphohexokinase (ECO:0000255 with HAMAP-Rule:MF_03184)

External Links
UniProt Q01813
EMBL D25328
AK092597
AK291841
AL731533
AL451164
AL451164
AL731533
BC002536
BC029138
M64784
CCDS CCDS55698.1
CCDS7059.1
PIR JC2055
RefSeq NP_001229268.1
NP_002618.1
UniGene Hs.26010
PDB 4RH3
4U1R
4WL0
4XYJ
4XYK
4XZ2
PDBsum 4RH3
4U1R
4WL0
4XYJ
4XYK
4XZ2
ProteinModelPortal Q01813
SMR Q01813
BioGrid 111235
DIP DIP-45850N
IntAct Q01813
MINT MINT-1159988
STRING 9606.ENSP00000370517
iPTMnet Q01813
PhosphoSitePlus Q01813
SwissPalm Q01813
BioMuta PFKP
DMDM 1346355
EPD Q01813
MaxQB Q01813
PaxDb Q01813
PeptideAtlas Q01813
PRIDE Q01813
DNASU 5214
Ensembl ENST00000381075
ENST00000381125
GeneID 5214
KEGG hsa:5214
UCSC uc001igp.4
CTD 5214
DisGeNET 5214
GeneCards PFKP
HGNC HGNC:8878
HPA HPA018257
HPA056484
MIM 171840
neXtProt NX_Q01813
OpenTargets ENSG00000067057
PharmGKB PA33217
eggNOG KOG2440
COG0205
GeneTree ENSGT00390000013209
HOGENOM HOG000200154
HOVERGEN HBG000976
InParanoid Q01813
KO K00850
OMA ISEGHKM
OrthoDB EOG091G01YN
PhylomeDB Q01813
TreeFam TF300411
BioCyc MetaCyc:HS00894-MONOMER
Reactome [www.reactome.org/content/detail/R-HSA-70171 R-HSA-70171]
SABIO-RK Q01813
UniPathway UPA00109
ChiTaRS PFKP
GeneWiki PFKP
GenomeRNAi 5214
PRO PR:Q01813
Proteomes UP000005640
Bgee ENSG00000067057
CleanEx HS_PFKP
ExpressionAtlas Q01813
Genevisible Q01813
GO GO:0005737
GO:0005829
GO:0070062
GO:0031012
GO:0016020
GO:0005634
GO:0003872
GO:0005524
GO:0045296
GO:0046872
GO:0032403
GO:0061621
GO:1990830
GO:0006002
HAMAP MF_03184
InterPro IPR009161
IPR022953
IPR015912
IPR000023
Pfam PF00365
PIRSF PIRSF000533
PRINTS PR00476
SUPFAM SSF53784
TIGRFAMs TIGR02478
PROSITE PS00433

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0045296

cadherin binding

PMID:25468996[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:25468996[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

enables

GO:0003872

6-phosphofructokinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P47859

F

Seeded From UniProt

complete

enables

GO:0070095

fructose-6-phosphate binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000344216
PomBase:SPBC16H5.02
RGD:3311
RGD:61893
RGD:68419
UniProtKB:P17858

F

Seeded From UniProt

complete

involved_in

GO:0061621

canonical glycolysis

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97548
PANTHER:PTN000344216

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10699
PANTHER:PTN000344216
RGD:3311
RGD:61893
RGD:68419

P

Seeded From UniProt

complete

enables

GO:0048029

monosaccharide binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000344216
RGD:3311

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10699
MGI:MGI:97548
PANTHER:PTN000344216
UniProtKB:P08237
UniProtKB:P17858
UniProtKB:Q01813

F

Seeded From UniProt

complete

involved_in

GO:0030388

fructose 1,6-bisphosphate metabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000344216
PomBase:SPBC16H5.02
RGD:3311
RGD:61893
RGD:68419
UniProtKB:P17858

P

Seeded From UniProt

complete

enables

GO:0016208

AMP binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000344216
RGD:68419

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000344223
UniProtKB:P08237

C

Seeded From UniProt

complete

involved_in

GO:0006007

glucose catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10699
PANTHER:PTN000344216
dictyBase:DDB_G0274111

P

Seeded From UniProt

complete

involved_in

GO:0006002

fructose 6-phosphate metabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97547
PANTHER:PTN000344216
PomBase:SPBC16H5.02
RGD:3311
RGD:61893
RGD:68419
UniProtKB:P08237
UniProtKB:P17858
dictyBase:DDB_G0274111

P

Seeded From UniProt

complete

part_of

GO:0005945

6-phosphofructokinase complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10699
PANTHER:PTN000344216
PomBase:SPBC16H5.02
SGD:S000003472
SGD:S000004818
UniProtKB:P08237
UniProtKB:P17858
dictyBase:DDB_G0274111

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10699
PANTHER:PTN000344216
PomBase:SPBC16H5.02
RGD:3311
RGD:61893
RGD:68419
UniProtKB:P08237
UniProtKB:P17858

F

Seeded From UniProt

complete

enables

GO:0003872

6-phosphofructokinase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10699
FB:FBgn0003071
MGI:MGI:97548
PANTHER:PTN000344216
PomBase:SPBC16H5.02
RGD:61893
RGD:68419
UniProtKB:P08237
UniProtKB:Q01813
dictyBase:DDB_G0274111

F

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

PMID:23209302[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1990830

cellular response to leukemia inhibitory factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WUA3
ensembl:ENSMUSP00000117030

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WUA3
ensembl:ENSMUSP00000117030

C

Seeded From UniProt

complete

enables

GO:0003872

6-phosphofructokinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000023
InterPro:IPR009161
InterPro:IPR015912
InterPro:IPR022953
InterPro:IPR035966

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009161

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009161

C

Seeded From UniProt

complete

involved_in

GO:0006002

fructose 6-phosphate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022953

P

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000023
InterPro:IPR009161
InterPro:IPR015912
InterPro:IPR022953
InterPro:IPR035966

P

Seeded From UniProt

complete

enables

GO:0003872

6-phosphofructokinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.1.11

F

Seeded From UniProt

complete

enables

GO:0003872

6-phosphofructokinase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166259

F

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166259

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166259

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25985179[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q01813-1

F

Seeded From UniProt

complete

enables

GO:0003872

6-phosphofructokinase activity

PMID:1834056[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061621

canonical glycolysis

Reactome:R-HSA-70171

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-70467

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

P

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0324
UniPathway:UPA00109

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ 3.0 3.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  4. ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page
  7. ↑ Webb, BA et al. (2015) Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature 523 111-4 PubMed GONUTS page
  8. ↑ Simpson, CJ & Fothergill-Gilmore, LA (1991) Isolation and sequence of a cDNA encoding human platelet phosphofructokinase. Biochem. Biophys. Res. Commun. 180 197-203 PubMed GONUTS page
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