HUMAN:PERF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PRF1 (synonyms: PFP)
Protein Name(s)	Perforin-1 P1 Cytolysin Lymphocyte pore-forming protein PFP
External Links
UniProt	P14222
EMBL	X13224 M28393 M31951 AK312754 AL355344 CH471083 BC047695 BC063043 AB209604 L40557
CCDS	CCDS7305.1
PIR	A45816
RefSeq	NP_001076585.1 NP_005032.2
UniGene	Hs.2200
ProteinModelPortal	P14222
SMR	P14222
BioGrid	111542
DIP	DIP-53288N
IntAct	P14222
MINT	MINT-1401322
STRING	9606.ENSP00000316746
BindingDB	P14222
ChEMBL	CHEMBL5480
DMDM	129819
PaxDb	P14222
PRIDE	P14222
Ensembl	ENST00000373209 ENST00000441259
GeneID	5551
KEGG	hsa:5551
UCSC	uc001jrf.4
CTD	5551
GeneCards	GC10M072357
GeneReviews	PRF1
HGNC	HGNC:9360
HPA	CAB002436
MIM	170280 603553
neXtProt	NX_P14222
Orphanet	540 391343 88
PharmGKB	PA33732
eggNOG	NOG39137
GeneTree	ENSGT00530000063725
HOGENOM	HOG000236309
HOVERGEN	HBG008168
InParanoid	P14222
KO	K07818
OMA	NYGTHFI
OrthoDB	EOG7SJD49
PhylomeDB	P14222
TreeFam	TF330498
GeneWiki	Perforin
GenomeRNAi	5551
NextBio	21512
PRO	PR:P14222
Proteomes	UP000005640
Bgee	P14222
CleanEx	HS_PRF1
ExpressionAtlas	P14222
Genevestigator	P14222
GO	GO:0044194 GO:0016023 GO:0031904 GO:0005576 GO:0016021 GO:0016020 GO:0005886 GO:0005509 GO:0022829 GO:0006915 GO:0006968 GO:0019835 GO:0002357 GO:0051607 GO:0002418 GO:0001771 GO:0051260 GO:0055085
Gene3D	2.60.40.150
InterPro	IPR000008 IPR020864 IPR020863
Pfam	PF00168 PF01823
SMART	SM00239 SM00457
SUPFAM	SSF49562
PROSITE	PS50004 PS00279 PS51412

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0051712	positive regulation of killing of cells of other organism	PMID:9756476^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0044194	cytolytic granule	PMID:9756476^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001771	immunological synapse formation	PMID:21438968^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10820	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:20889983^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0044194	cytolytic granule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10820	C	Seeded From UniProt	complete
enables	GO:0022829	wide pore channel activity	PMID:20889983^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10820	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:20889983^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10820	F	Seeded From UniProt	complete
involved_in	GO:0002418	immune response to tumor cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10820	P	Seeded From UniProt	complete
involved_in	GO:0002357	defense response to tumor cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10820	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21685908^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14222	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21037563^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14222	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022829	P	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022829	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	P	Seeded From UniProt	complete
part_of	GO:0044194	cytolytic granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	C	Seeded From UniProt	complete
enables	GO:0022829	wide pore channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	F	Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	F	Seeded From UniProt	complete
involved_in	GO:0002418	immune response to tumor cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	P	Seeded From UniProt	complete
involved_in	GO:0002357	defense response to tumor cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	P	Seeded From UniProt	complete
involved_in	GO:0001913	T cell mediated cytotoxicity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10820 ensembl:ENSMUSP00000151354	P	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037300	F	Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037300	P	Seeded From UniProt	complete
involved_in	GO:0006968	cellular defense response	PMID:10779745^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10779745^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0031904	endosome lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0327	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Stenger, S et al. (1998) An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 282 121-5 PubMed GONUTS page
↑ Pattu, V et al. (2011) Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic 12 890-901 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Praper, T et al. (2011) Human perforin employs different avenues to damage membranes. J. Biol. Chem. 286 2946-55 PubMed GONUTS page
↑ Thiery, J et al. (2011) Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat. Immunol. 12 770-7 PubMed GONUTS page
↑ Law, RH et al. (2010) The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature 468 447-51 PubMed GONUTS page
↑ ^7.0 ^7.1 Takahashi, T et al. (2000) Analysis of human V alpha 24+ CD4+ NKT cells activated by alpha-glycosylceramide-pulsed monocyte-derived dendritic cells. J. Immunol. 164 4458-64 PubMed GONUTS page

[PMID:9756476-1] 1.0 ^1.1 Stenger, S et al. (1998) An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 282 121-5 PubMed GONUTS page

[PMID:21438968-2] Pattu, V et al. (2011) Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic 12 890-901 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:20889983-4] 4.0 ^4.1 ^4.2 Praper, T et al. (2011) Human perforin employs different avenues to damage membranes. J. Biol. Chem. 286 2946-55 PubMed GONUTS page

[PMID:21685908-5] Thiery, J et al. (2011) Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat. Immunol. 12 770-7 PubMed GONUTS page

[PMID:21037563-6] Law, RH et al. (2010) The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature 468 447-51 PubMed GONUTS page

[PMID:10779745-7] 7.0 ^7.1 Takahashi, T et al. (2000) Analysis of human V alpha 24+ CD4+ NKT cells activated by alpha-glycosylceramide-pulsed monocyte-derived dendritic cells. J. Immunol. 164 4458-64 PubMed GONUTS page

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HUMAN:PERF

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