HUMAN:PAR2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	F2RL1 (synonyms: GPR11, PAR2)
Protein Name(s)	Proteinase-activated receptor 2 PAR-2 Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1 Proteinase-activated receptor 2, alternate cleaved 1 Proteinase-activated receptor 2, alternate cleaved 2
External Links
UniProt	P55085
EMBL	Z49993 Z49994 U34038 AY336105 AF400075 BT009856 CH471084 BC012453 BC018130 U36753
CCDS	CCDS4033.1
PIR	S66518
RefSeq	NP_005233.3
UniGene	Hs.744181
ProteinModelPortal	P55085
SMR	P55085
BioGrid	108449
IntAct	P55085
MINT	MINT-1326650
STRING	9606.ENSP00000296677
BindingDB	P55085
ChEMBL	CHEMBL5963
GuidetoPHARMACOLOGY	348
PhosphoSite	P55085
DMDM	1709580
MaxQB	P55085
PaxDb	P55085
PRIDE	P55085
DNASU	2150
Ensembl	ENST00000296677
GeneID	2150
KEGG	hsa:2150
UCSC	uc003keo.3
CTD	2150
GeneCards	GC05P076120
HGNC	HGNC:3538
HPA	CAB012989
MIM	600933
neXtProt	NX_P55085
PharmGKB	PA27947
eggNOG	NOG145128
HOGENOM	HOG000116291
HOVERGEN	HBG105658
InParanoid	P55085
KO	K04234
PhylomeDB	P55085
TreeFam	TF330775
Reactome	REACT_14819 REACT_18283
GeneWiki	Protease_activated_receptor_2
GenomeRNAi	2150
NextBio	8689
PMAP-CutDB	P55085
PRO	PR:P55085
Proteomes	UP000005640
Bgee	P55085
CleanEx	HS_F2RL1
ExpressionAtlas	P55085
Genevestigator	P55085
GO	GO:0005769 GO:0005794 GO:0005887 GO:0005886 GO:0031143 GO:0001965 GO:0031681 GO:0004930 GO:0004872 GO:0005102 GO:0015057 GO:0007596 GO:0035926 GO:0090195 GO:0051607 GO:0061028 GO:0007186 GO:0006954 GO:0045087 GO:0072643 GO:0050702 GO:0072608 GO:0050900 GO:0070661 GO:0097029 GO:0090198 GO:0046329 GO:0034140 GO:0010804 GO:0042119 GO:0030836 GO:0030335 GO:0050921 GO:0002741 GO:0007204 GO:0043311 GO:0070374 GO:0003104 GO:0043123 GO:2000778 GO:2000484 GO:0046330 GO:0002690 GO:0070963 GO:0060100 GO:0014068 GO:0050927 GO:0031274 GO:1900135 GO:0035025 GO:0032930 GO:0034137 GO:0034141 GO:0034145 GO:0045944 GO:0045909 GO:0030193 GO:0043122 GO:0046328 GO:0002286
InterPro	IPR000276 IPR017452 IPR002281 IPR003912
Pfam	PF00001
PRINTS	PR00237 PR01428 PR01152
PROSITE	PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005886	plasma membrane	PMID:28445455^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:28445455^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:28445455^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:23202369^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P63000)	Seeded From UniProt	complete
involved_in	GO:0045217	cell-cell junction maintenance	PMID:23202369^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0072672) occurs_in:(CL:0000071)	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:22547407^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22547407^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050927	positive regulation of positive chemotaxis	PMID:17991872^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030193	regulation of blood coagulation	PMID:17848177^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:17848177^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002690	positive regulation of leukocyte chemotaxis	PMID:17991872^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	PMID:11447194^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	PMID:15155775^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	PMID:19865078^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	PMID:18622013^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	PMID:17404307^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	PMID:15155775^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900135	positive regulation of renin secretion into blood stream	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0097029	mature conventional dendritic cell differentiation	PMID:16478888^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097029	mature conventional dendritic cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0090198	negative regulation of chemokine secretion	PMID:19865078^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090195	chemokine secretion	PMID:19494303^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090195	chemokine secretion	PMID:21501162^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072643	interferon-gamma secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0072608	interleukin-10 secretion	PMID:18453611^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070963	positive regulation of neutrophil mediated killing of gram-negative bacterium	PMID:21501162^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070661	leukocyte proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:10725339^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0061028	establishment of endothelial barrier	PMID:20826780^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060100	positive regulation of phagocytosis, engulfment	PMID:21501162^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:19494303^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:18453611^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050921	positive regulation of chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	PMID:15155775^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	PMID:15155775^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:11413129^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046329	negative regulation of JNK cascade	PMID:19781631^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	PMID:16410250^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16410250^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0043311	positive regulation of eosinophil degranulation	PMID:11714832^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:11413129^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	PMID:18453611^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042119	neutrophil activation	PMID:15155775^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035926	chemokine (C-C motif) ligand 2 secretion	PMID:21501162^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	PMID:20826780^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	PMID:18622013^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	PMID:19865078^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	PMID:19865078^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	PMID:19865078^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	PMID:11714832^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031681	G-protein beta-subunit binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	F		Seeded From UniProt	complete
involved_in	GO:0031274	positive regulation of pseudopodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	C		Seeded From UniProt	complete
involved_in	GO:0030836	positive regulation of actin filament depolymerization	PMID:17500066^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
involved_in	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	PMID:19781631^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:10725339^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:18622013^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	F		Seeded From UniProt	complete
involved_in	GO:0003104	positive regulation of glomerular filtration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63645	P		Seeded From UniProt	complete
involved_in	GO:0002741	positive regulation of cytokine secretion involved in immune response	PMID:11441110^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002286	T cell activation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	P		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55086	F		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000660850 RGD:2586	P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101802 MGI:MGI:101910 PANTHER:PTN000660850 UniProtKB:P55085 UniProtKB:Q9Y2T6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1929509 PANTHER:PTN000660850 UniProtKB:P55085 UniProtKB:Q99678 UniProtKB:Q9HC97 UniProtKB:Q9Y2T6	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101802 MGI:MGI:101910 MGI:MGI:2441992 PANTHER:PTN000660850 UniProtKB:P55085 UniProtKB:Q8IYL9 UniProtKB:Q99678 UniProtKB:Q9HC97	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900135	positive regulation of renin secretion into blood stream	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0097029	mature conventional dendritic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0090195	chemokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0072643	interferon-gamma secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0070661	leukocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0050921	positive regulation of chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
enables	GO:0031681	G-protein beta-subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	F		Seeded From UniProt	complete
involved_in	GO:0031274	positive regulation of pseudopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	F		Seeded From UniProt	complete
involved_in	GO:0002286	T cell activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	P		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55086 ensembl:ENSMUSP00000022185	F		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63645 ensembl:ENSRNOP00000058298	P		Seeded From UniProt	complete
involved_in	GO:0003104	positive regulation of glomerular filtration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63645 ensembl:ENSRNOP00000058298	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003912	P		Seeded From UniProt	complete
enables	GO:0015057	thrombin-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002281 InterPro:IPR003912	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR002281 InterPro:IPR003912 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0070493	thrombin-activated receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002281 InterPro:IPR003912	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:8615752^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:7556175^[25] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:8615752^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:8615752^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:7556175^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:8615752^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-389463 Reactome:R-HSA-379048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Cheng, RKY et al. (2017) Structural insight into allosteric modulation of protease-activated receptor 2. Nature 545 112-115 PubMed GONUTS page
↑ ^2.0 ^2.1 Kuckleburg, CJ & Newman, PJ (2013) Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler. Thromb. Vasc. Biol. 33 275-84 PubMed GONUTS page
↑ ^3.0 ^3.1 Dores, MR et al. (2012) ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J. Cell Biol. 197 407-19 PubMed GONUTS page
↑ ^4.0 ^4.1 Siegbahn, A et al. (2008) TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC. Arterioscler. Thromb. Vasc. Biol. 28 135-41 PubMed GONUTS page
↑ ^5.0 ^5.1 Banfi, C et al. (2007) Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J. Thromb. Haemost. 5 2437-44 PubMed GONUTS page
↑ Lourbakos, A et al. (2001) Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect. Immun. 69 5121-30 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Shpacovitch, VM et al. (2004) Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices. J. Leukoc. Biol. 76 388-98 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Nhu, QM et al. (2010) Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo. Mucosal Immunol 3 29-39 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Rallabhandi, P et al. (2008) Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J. Biol. Chem. 283 24314-25 PubMed GONUTS page
↑ Chiu, LL et al. (2007) Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2. J. Immunol. 178 5237-44 PubMed GONUTS page
↑ Csernok, E et al. (2006) Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. Blood 107 4440-8 PubMed GONUTS page
↑ ^12.0 ^12.1 Khoufache, K et al. (2009) Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J. Immunol. 182 7795-802 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Shpacovitch, VM et al. (2011) Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes. Immunology 133 329-39 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Feld, M et al. (2008) Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection. J. Immunol. 180 6903-10 PubMed GONUTS page
↑ ^15.0 ^15.1 DeFea, KA et al. (2000) beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 148 1267-81 PubMed GONUTS page
↑ ^16.0 ^16.1 Bae, JS et al. (2010) Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J. Biol. Chem. 285 34803-12 PubMed GONUTS page
↑ ^17.0 ^17.1 Kanke, T et al. (2001) Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes. J. Biol. Chem. 276 31657-66 PubMed GONUTS page
↑ ^18.0 ^18.1 McIntosh, K et al. (2010) Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs. Cell. Signal. 22 265-73 PubMed GONUTS page
↑ ^19.0 ^19.1 Luo, W et al. (2006) Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1. J. Biol. Chem. 281 7927-36 PubMed GONUTS page
↑ ^20.0 ^20.1 Miike, S et al. (2001) Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. J. Immunol. 167 6615-22 PubMed GONUTS page
↑ Zoudilova, M et al. (2007) Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J. Biol. Chem. 282 20634-46 PubMed GONUTS page
↑ Sun, G et al. (2001) Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J. Immunol. 167 1014-21 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Bohm, SK et al. (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J. 314 ( Pt 3) 1009-16 PubMed GONUTS page
↑ ^25.0 ^25.1 Nystedt, S et al. (1995) Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur. J. Biochem. 232 84-9 PubMed GONUTS page

[PMID:28445455-1] 1.0 ^1.1 ^1.2 Cheng, RKY et al. (2017) Structural insight into allosteric modulation of protease-activated receptor 2. Nature 545 112-115 PubMed GONUTS page

[PMID:23202369-2] 2.0 ^2.1 Kuckleburg, CJ & Newman, PJ (2013) Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler. Thromb. Vasc. Biol. 33 275-84 PubMed GONUTS page

[PMID:22547407-3] 3.0 ^3.1 Dores, MR et al. (2012) ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J. Cell Biol. 197 407-19 PubMed GONUTS page

[PMID:17991872-4] 4.0 ^4.1 Siegbahn, A et al. (2008) TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC. Arterioscler. Thromb. Vasc. Biol. 28 135-41 PubMed GONUTS page

[PMID:17848177-5] 5.0 ^5.1 Banfi, C et al. (2007) Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J. Thromb. Haemost. 5 2437-44 PubMed GONUTS page

[PMID:11447194-6] Lourbakos, A et al. (2001) Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect. Immun. 69 5121-30 PubMed GONUTS page

[PMID:15155775-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Shpacovitch, VM et al. (2004) Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices. J. Leukoc. Biol. 76 388-98 PubMed GONUTS page

[PMID:19865078-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Nhu, QM et al. (2010) Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo. Mucosal Immunol 3 29-39 PubMed GONUTS page

[PMID:18622013-9] 9.0 ^9.1 ^9.2 Rallabhandi, P et al. (2008) Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J. Biol. Chem. 283 24314-25 PubMed GONUTS page

[PMID:17404307-10] Chiu, LL et al. (2007) Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2. J. Immunol. 178 5237-44 PubMed GONUTS page

[PMID:16478888-11] Csernok, E et al. (2006) Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. Blood 107 4440-8 PubMed GONUTS page

[PMID:19494303-12] 12.0 ^12.1 Khoufache, K et al. (2009) Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J. Immunol. 182 7795-802 PubMed GONUTS page

[PMID:21501162-13] 13.0 ^13.1 ^13.2 ^13.3 Shpacovitch, VM et al. (2011) Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes. Immunology 133 329-39 PubMed GONUTS page

[PMID:18453611-14] 14.0 ^14.1 ^14.2 Feld, M et al. (2008) Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection. J. Immunol. 180 6903-10 PubMed GONUTS page

[PMID:10725339-15] 15.0 ^15.1 DeFea, KA et al. (2000) beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 148 1267-81 PubMed GONUTS page

[PMID:20826780-16] 16.0 ^16.1 Bae, JS et al. (2010) Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J. Biol. Chem. 285 34803-12 PubMed GONUTS page

[PMID:11413129-17] 17.0 ^17.1 Kanke, T et al. (2001) Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes. J. Biol. Chem. 276 31657-66 PubMed GONUTS page

[PMID:19781631-18] 18.0 ^18.1 McIntosh, K et al. (2010) Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs. Cell. Signal. 22 265-73 PubMed GONUTS page

[PMID:16410250-19] 19.0 ^19.1 Luo, W et al. (2006) Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1. J. Biol. Chem. 281 7927-36 PubMed GONUTS page

[PMID:11714832-20] 20.0 ^20.1 Miike, S et al. (2001) Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. J. Immunol. 167 6615-22 PubMed GONUTS page

[PMID:17500066-21] Zoudilova, M et al. (2007) Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J. Biol. Chem. 282 20634-46 PubMed GONUTS page

[PMID:11441110-22] Sun, G et al. (2001) Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J. Immunol. 167 1014-21 PubMed GONUTS page

[PMID:21873635-23] 23.0 ^23.1 ^23.2 ^23.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8615752-24] 24.0 ^24.1 ^24.2 ^24.3 Bohm, SK et al. (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J. 314 ( Pt 3) 1009-16 PubMed GONUTS page

[PMID:7556175-25] 25.0 ^25.1 Nystedt, S et al. (1995) Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur. J. Biochem. 232 84-9 PubMed GONUTS page

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