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HUMAN:PAR2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) F2RL1 (synonyms: GPR11, PAR2)
Protein Name(s) Proteinase-activated receptor 2

PAR-2 Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1 Proteinase-activated receptor 2, alternate cleaved 1 Proteinase-activated receptor 2, alternate cleaved 2

External Links
UniProt P55085
EMBL Z49993
Z49994
U34038
AY336105
AF400075
BT009856
CH471084
BC012453
BC018130
U36753
CCDS CCDS4033.1
PIR S66518
RefSeq NP_005233.3
UniGene Hs.744181
ProteinModelPortal P55085
SMR P55085
BioGrid 108449
IntAct P55085
MINT MINT-1326650
STRING 9606.ENSP00000296677
BindingDB P55085
ChEMBL CHEMBL5963
GuidetoPHARMACOLOGY 348
PhosphoSite P55085
DMDM 1709580
MaxQB P55085
PaxDb P55085
PRIDE P55085
DNASU 2150
Ensembl ENST00000296677
GeneID 2150
KEGG hsa:2150
UCSC uc003keo.3
CTD 2150
GeneCards GC05P076120
HGNC HGNC:3538
HPA CAB012989
MIM 600933
neXtProt NX_P55085
PharmGKB PA27947
eggNOG NOG145128
HOGENOM HOG000116291
HOVERGEN HBG105658
InParanoid P55085
KO K04234
PhylomeDB P55085
TreeFam TF330775
Reactome REACT_14819
REACT_18283
GeneWiki Protease_activated_receptor_2
GenomeRNAi 2150
NextBio 8689
PMAP-CutDB P55085
PRO PR:P55085
Proteomes UP000005640
Bgee P55085
CleanEx HS_F2RL1
ExpressionAtlas P55085
Genevestigator P55085
GO GO:0005769
GO:0005794
GO:0005887
GO:0005886
GO:0031143
GO:0001965
GO:0031681
GO:0004930
GO:0004872
GO:0005102
GO:0015057
GO:0007596
GO:0035926
GO:0090195
GO:0051607
GO:0061028
GO:0007186
GO:0006954
GO:0045087
GO:0072643
GO:0050702
GO:0072608
GO:0050900
GO:0070661
GO:0097029
GO:0090198
GO:0046329
GO:0034140
GO:0010804
GO:0042119
GO:0030836
GO:0030335
GO:0050921
GO:0002741
GO:0007204
GO:0043311
GO:0070374
GO:0003104
GO:0043123
GO:2000778
GO:2000484
GO:0046330
GO:0002690
GO:0070963
GO:0060100
GO:0014068
GO:0050927
GO:0031274
GO:1900135
GO:0035025
GO:0032930
GO:0034137
GO:0034141
GO:0034145
GO:0045944
GO:0045909
GO:0030193
GO:0043122
GO:0046328
GO:0002286
InterPro IPR000276
IPR017452
IPR002281
IPR003912
Pfam PF00001
PRINTS PR00237
PR01428
PR01152
PROSITE PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005886

plasma membrane

PMID:28445455[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:28445455[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:28445455[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

PMID:23202369[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P63000)

Seeded From UniProt

complete

involved_in

GO:0045217

cell-cell junction maintenance

PMID:23202369[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • happens_during:(GO:0072672)
  • occurs_in:(CL:0000071)

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:22547407[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:22547407[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050927

positive regulation of positive chemotaxis

PMID:17991872[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030193

regulation of blood coagulation

PMID:17848177[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:17848177[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002690

positive regulation of leukocyte chemotaxis

PMID:17991872[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000778

positive regulation of interleukin-6 secretion

PMID:11447194[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000778

positive regulation of interleukin-6 secretion

PMID:15155775[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000484

positive regulation of interleukin-8 secretion

PMID:19865078[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000484

positive regulation of interleukin-8 secretion

PMID:18622013[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000484

positive regulation of interleukin-8 secretion

PMID:17404307[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000484

positive regulation of interleukin-8 secretion

PMID:15155775[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900135

positive regulation of renin secretion into blood stream

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0097029

mature conventional dendritic cell differentiation

PMID:16478888[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097029

mature conventional dendritic cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0090198

negative regulation of chemokine secretion

PMID:19865078[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090195

chemokine secretion

PMID:19494303[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090195

chemokine secretion

PMID:21501162[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072643

interferon-gamma secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0072608

interleukin-10 secretion

PMID:18453611[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070963

positive regulation of neutrophil mediated killing of gram-negative bacterium

PMID:21501162[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070661

leukocyte proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:10725339[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0061028

establishment of endothelial barrier

PMID:20826780[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060100

positive regulation of phagocytosis, engulfment

PMID:21501162[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:19494303[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:18453611[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050921

positive regulation of chemotaxis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

PMID:15155775[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050702

interleukin-1 beta secretion

PMID:15155775[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046330

positive regulation of JNK cascade

PMID:11413129[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046329

negative regulation of JNK cascade

PMID:19781631[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046328

regulation of JNK cascade

PMID:16410250[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16410250[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097755

positive regulation of blood vessel diameter

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0043311

positive regulation of eosinophil degranulation

PMID:11714832[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:11413129[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

PMID:18453611[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042119

neutrophil activation

PMID:15155775[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035926

chemokine (C-C motif) ligand 2 secretion

PMID:21501162[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

PMID:20826780[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0034145

positive regulation of toll-like receptor 4 signaling pathway

PMID:18622013[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034141

positive regulation of toll-like receptor 3 signaling pathway

PMID:19865078[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034140

negative regulation of toll-like receptor 3 signaling pathway

PMID:19865078[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034137

positive regulation of toll-like receptor 2 signaling pathway

PMID:19865078[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032930

positive regulation of superoxide anion generation

PMID:11714832[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031681

G-protein beta-subunit binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

F

Seeded From UniProt

complete

involved_in

GO:0031274

positive regulation of pseudopodium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

part_of

GO:0031143

pseudopodium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

C

Seeded From UniProt

complete

involved_in

GO:0030836

positive regulation of actin filament depolymerization

PMID:17500066[21]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

involved_in

GO:0010804

negative regulation of tumor necrosis factor-mediated signaling pathway

PMID:19781631[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:10725339[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:18622013[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

F

Seeded From UniProt

complete

involved_in

GO:0003104

positive regulation of glomerular filtration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q63645

P

Seeded From UniProt

complete

involved_in

GO:0002741

positive regulation of cytokine secretion involved in immune response

PMID:11441110[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002286

T cell activation involved in immune response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

P

Seeded From UniProt

complete

enables

GO:0001965

G-protein alpha-subunit binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55086

F

Seeded From UniProt

complete

involved_in

GO:0051482

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

PMID:21873635[23]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000660850
RGD:2586

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

PMID:21873635[23]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101802
MGI:MGI:101910
PANTHER:PTN000660850
UniProtKB:P55085
UniProtKB:Q9Y2T6

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[23]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1929509
PANTHER:PTN000660850
UniProtKB:P55085
UniProtKB:Q99678
UniProtKB:Q9HC97
UniProtKB:Q9Y2T6

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[23]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101802
MGI:MGI:101910
MGI:MGI:2441992
PANTHER:PTN000660850
UniProtKB:P55085
UniProtKB:Q8IYL9
UniProtKB:Q99678
UniProtKB:Q9HC97

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1900135

positive regulation of renin secretion into blood stream

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0097755

positive regulation of blood vessel diameter

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0097029

mature conventional dendritic cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0090195

chemokine secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0072643

interferon-gamma secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0070661

leukocyte proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0050921

positive regulation of chemotaxis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

enables

GO:0031681

G-protein beta-subunit binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

F

Seeded From UniProt

complete

involved_in

GO:0031274

positive regulation of pseudopodium assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

part_of

GO:0031143

pseudopodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

C

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

F

Seeded From UniProt

complete

involved_in

GO:0002286

T cell activation involved in immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

P

Seeded From UniProt

complete

enables

GO:0001965

G-protein alpha-subunit binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P55086
ensembl:ENSMUSP00000022185

F

Seeded From UniProt

complete

involved_in

GO:0097755

positive regulation of blood vessel diameter

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63645
ensembl:ENSRNOP00000058298

P

Seeded From UniProt

complete

involved_in

GO:0003104

positive regulation of glomerular filtration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63645
ensembl:ENSRNOP00000058298

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

P

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003912

P

Seeded From UniProt

complete

enables

GO:0015057

thrombin-activated receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002281
InterPro:IPR003912

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR002281
InterPro:IPR003912
InterPro:IPR017452

C

Seeded From UniProt

complete

involved_in

GO:0070493

thrombin-activated receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002281
InterPro:IPR003912

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:8615752[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:7556175[25]
Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:8615752[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:8615752[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:7556175[25]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:8615752[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-389463
Reactome:R-HSA-379048

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

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  2. 2.0 2.1 Kuckleburg, CJ & Newman, PJ (2013) Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler. Thromb. Vasc. Biol. 33 275-84 PubMed GONUTS page
  3. 3.0 3.1 Dores, MR et al. (2012) ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J. Cell Biol. 197 407-19 PubMed GONUTS page
  4. 4.0 4.1 Siegbahn, A et al. (2008) TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC. Arterioscler. Thromb. Vasc. Biol. 28 135-41 PubMed GONUTS page
  5. 5.0 5.1 Banfi, C et al. (2007) Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J. Thromb. Haemost. 5 2437-44 PubMed GONUTS page
  6. Lourbakos, A et al. (2001) Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect. Immun. 69 5121-30 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Shpacovitch, VM et al. (2004) Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices. J. Leukoc. Biol. 76 388-98 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Nhu, QM et al. (2010) Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo. Mucosal Immunol 3 29-39 PubMed GONUTS page
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  10. Chiu, LL et al. (2007) Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2. J. Immunol. 178 5237-44 PubMed GONUTS page
  11. Csernok, E et al. (2006) Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. Blood 107 4440-8 PubMed GONUTS page
  12. 12.0 12.1 Khoufache, K et al. (2009) Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J. Immunol. 182 7795-802 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 Shpacovitch, VM et al. (2011) Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes. Immunology 133 329-39 PubMed GONUTS page
  14. 14.0 14.1 14.2 Feld, M et al. (2008) Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection. J. Immunol. 180 6903-10 PubMed GONUTS page
  15. 15.0 15.1 DeFea, KA et al. (2000) beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 148 1267-81 PubMed GONUTS page
  16. 16.0 16.1 Bae, JS et al. (2010) Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J. Biol. Chem. 285 34803-12 PubMed GONUTS page
  17. 17.0 17.1 Kanke, T et al. (2001) Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes. J. Biol. Chem. 276 31657-66 PubMed GONUTS page
  18. 18.0 18.1 McIntosh, K et al. (2010) Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs. Cell. Signal. 22 265-73 PubMed GONUTS page
  19. 19.0 19.1 Luo, W et al. (2006) Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1. J. Biol. Chem. 281 7927-36 PubMed GONUTS page
  20. 20.0 20.1 Miike, S et al. (2001) Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. J. Immunol. 167 6615-22 PubMed GONUTS page
  21. Zoudilova, M et al. (2007) Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J. Biol. Chem. 282 20634-46 PubMed GONUTS page
  22. Sun, G et al. (2001) Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J. Immunol. 167 1014-21 PubMed GONUTS page
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