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HUMAN:PAR2
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | F2RL1 (synonyms: GPR11, PAR2) | |
Protein Name(s) | Proteinase-activated receptor 2
PAR-2 Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1 Proteinase-activated receptor 2, alternate cleaved 1 Proteinase-activated receptor 2, alternate cleaved 2 | |
External Links | ||
UniProt | P55085 | |
EMBL | Z49993 Z49994 U34038 AY336105 AF400075 BT009856 CH471084 BC012453 BC018130 U36753 | |
CCDS | CCDS4033.1 | |
PIR | S66518 | |
RefSeq | NP_005233.3 | |
UniGene | Hs.744181 | |
ProteinModelPortal | P55085 | |
SMR | P55085 | |
BioGrid | 108449 | |
IntAct | P55085 | |
MINT | MINT-1326650 | |
STRING | 9606.ENSP00000296677 | |
BindingDB | P55085 | |
ChEMBL | CHEMBL5963 | |
GuidetoPHARMACOLOGY | 348 | |
PhosphoSite | P55085 | |
DMDM | 1709580 | |
MaxQB | P55085 | |
PaxDb | P55085 | |
PRIDE | P55085 | |
DNASU | 2150 | |
Ensembl | ENST00000296677 | |
GeneID | 2150 | |
KEGG | hsa:2150 | |
UCSC | uc003keo.3 | |
CTD | 2150 | |
GeneCards | GC05P076120 | |
HGNC | HGNC:3538 | |
HPA | CAB012989 | |
MIM | 600933 | |
neXtProt | NX_P55085 | |
PharmGKB | PA27947 | |
eggNOG | NOG145128 | |
HOGENOM | HOG000116291 | |
HOVERGEN | HBG105658 | |
InParanoid | P55085 | |
KO | K04234 | |
PhylomeDB | P55085 | |
TreeFam | TF330775 | |
Reactome | REACT_14819 REACT_18283 | |
GeneWiki | Protease_activated_receptor_2 | |
GenomeRNAi | 2150 | |
NextBio | 8689 | |
PMAP-CutDB | P55085 | |
PRO | PR:P55085 | |
Proteomes | UP000005640 | |
Bgee | P55085 | |
CleanEx | HS_F2RL1 | |
ExpressionAtlas | P55085 | |
Genevestigator | P55085 | |
GO | GO:0005769 GO:0005794 GO:0005887 GO:0005886 GO:0031143 GO:0001965 GO:0031681 GO:0004930 GO:0004872 GO:0005102 GO:0015057 GO:0007596 GO:0035926 GO:0090195 GO:0051607 GO:0061028 GO:0007186 GO:0006954 GO:0045087 GO:0072643 GO:0050702 GO:0072608 GO:0050900 GO:0070661 GO:0097029 GO:0090198 GO:0046329 GO:0034140 GO:0010804 GO:0042119 GO:0030836 GO:0030335 GO:0050921 GO:0002741 GO:0007204 GO:0043311 GO:0070374 GO:0003104 GO:0043123 GO:2000778 GO:2000484 GO:0046330 GO:0002690 GO:0070963 GO:0060100 GO:0014068 GO:0050927 GO:0031274 GO:1900135 GO:0035025 GO:0032930 GO:0034137 GO:0034141 GO:0034145 GO:0045944 GO:0045909 GO:0030193 GO:0043122 GO:0046328 GO:0002286 | |
InterPro | IPR000276 IPR017452 IPR002281 IPR003912 | |
Pfam | PF00001 | |
PRINTS | PR00237 PR01428 PR01152 | |
PROSITE | PS50262 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P63000) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045217 |
cell-cell junction maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005769 |
early endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050927 |
positive regulation of positive chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030193 |
regulation of blood coagulation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002690 |
positive regulation of leukocyte chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000484 |
positive regulation of interleukin-8 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000484 |
positive regulation of interleukin-8 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000484 |
positive regulation of interleukin-8 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000484 |
positive regulation of interleukin-8 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1900135 |
positive regulation of renin secretion into blood stream |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097029 |
mature conventional dendritic cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097029 |
mature conventional dendritic cell differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090198 |
negative regulation of chemokine secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090195 |
chemokine secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090195 |
chemokine secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072643 |
interferon-gamma secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072608 |
interleukin-10 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070963 |
positive regulation of neutrophil mediated killing of gram-negative bacterium |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070661 |
leukocyte proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061028 |
establishment of endothelial barrier |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060100 |
positive regulation of phagocytosis, engulfment |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050921 |
positive regulation of chemotaxis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050900 |
leukocyte migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050702 |
interleukin-1 beta secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046329 |
negative regulation of JNK cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046328 |
regulation of JNK cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043311 |
positive regulation of eosinophil degranulation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042119 |
neutrophil activation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035926 |
chemokine (C-C motif) ligand 2 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035025 |
positive regulation of Rho protein signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035025 |
positive regulation of Rho protein signal transduction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034145 |
positive regulation of toll-like receptor 4 signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034141 |
positive regulation of toll-like receptor 3 signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034140 |
negative regulation of toll-like receptor 3 signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034137 |
positive regulation of toll-like receptor 2 signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032930 |
positive regulation of superoxide anion generation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0031681 |
G-protein beta-subunit binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031274 |
positive regulation of pseudopodium assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031143 |
pseudopodium |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030836 |
positive regulation of actin filament depolymerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003104 |
positive regulation of glomerular filtration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002741 |
positive regulation of cytokine secretion involved in immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002286 |
T cell activation involved in immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001965 |
G-protein alpha-subunit binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051482 |
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000660850 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035025 |
positive regulation of Rho protein signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101802 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1929509 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101802 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:1900135 |
positive regulation of renin secretion into blood stream |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097029 |
mature conventional dendritic cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090195 |
chemokine secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0072643 |
interferon-gamma secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070661 |
leukocyte proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050921 |
positive regulation of chemotaxis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035025 |
positive regulation of Rho protein signal transduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0031681 |
G-protein beta-subunit binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031274 |
positive regulation of pseudopodium assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0031143 |
pseudopodium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002286 |
T cell activation involved in immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0001965 |
G-protein alpha-subunit binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P55086 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097755 |
positive regulation of blood vessel diameter |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63645 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003104 |
positive regulation of glomerular filtration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q63645 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007596 |
blood coagulation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0015057 |
thrombin-activated receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000276 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070493 |
thrombin-activated receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
PMID:7556175[25] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-749452 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Cheng, RKY et al. (2017) Structural insight into allosteric modulation of protease-activated receptor 2. Nature 545 112-115 PubMed GONUTS page
- ↑ 2.0 2.1 Kuckleburg, CJ & Newman, PJ (2013) Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler. Thromb. Vasc. Biol. 33 275-84 PubMed GONUTS page
- ↑ 3.0 3.1 Dores, MR et al. (2012) ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J. Cell Biol. 197 407-19 PubMed GONUTS page
- ↑ 4.0 4.1 Siegbahn, A et al. (2008) TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC. Arterioscler. Thromb. Vasc. Biol. 28 135-41 PubMed GONUTS page
- ↑ 5.0 5.1 Banfi, C et al. (2007) Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J. Thromb. Haemost. 5 2437-44 PubMed GONUTS page
- ↑ Lourbakos, A et al. (2001) Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect. Immun. 69 5121-30 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Shpacovitch, VM et al. (2004) Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices. J. Leukoc. Biol. 76 388-98 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Nhu, QM et al. (2010) Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo. Mucosal Immunol 3 29-39 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Rallabhandi, P et al. (2008) Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J. Biol. Chem. 283 24314-25 PubMed GONUTS page
- ↑ Chiu, LL et al. (2007) Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2. J. Immunol. 178 5237-44 PubMed GONUTS page
- ↑ Csernok, E et al. (2006) Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. Blood 107 4440-8 PubMed GONUTS page
- ↑ 12.0 12.1 Khoufache, K et al. (2009) Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J. Immunol. 182 7795-802 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Shpacovitch, VM et al. (2011) Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes. Immunology 133 329-39 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Feld, M et al. (2008) Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection. J. Immunol. 180 6903-10 PubMed GONUTS page
- ↑ 15.0 15.1 DeFea, KA et al. (2000) beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 148 1267-81 PubMed GONUTS page
- ↑ 16.0 16.1 Bae, JS et al. (2010) Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. J. Biol. Chem. 285 34803-12 PubMed GONUTS page
- ↑ 17.0 17.1 Kanke, T et al. (2001) Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes. J. Biol. Chem. 276 31657-66 PubMed GONUTS page
- ↑ 18.0 18.1 McIntosh, K et al. (2010) Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs. Cell. Signal. 22 265-73 PubMed GONUTS page
- ↑ 19.0 19.1 Luo, W et al. (2006) Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1. J. Biol. Chem. 281 7927-36 PubMed GONUTS page
- ↑ 20.0 20.1 Miike, S et al. (2001) Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. J. Immunol. 167 6615-22 PubMed GONUTS page
- ↑ Zoudilova, M et al. (2007) Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J. Biol. Chem. 282 20634-46 PubMed GONUTS page
- ↑ Sun, G et al. (2001) Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J. Immunol. 167 1014-21 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 Bohm, SK et al. (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J. 314 ( Pt 3) 1009-16 PubMed GONUTS page
- ↑ 25.0 25.1 Nystedt, S et al. (1995) Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur. J. Biochem. 232 84-9 PubMed GONUTS page
c
e
g
i
- GO:0002376 ! immune system process
- GO:0006954 ! inflammatory response
- GO:0045087 ! innate immune response
- GO:0016021 ! integral component of membrane
- GO:0005887 ! integral component of plasma membrane
- GO:0072643 ! interferon-gamma secretion
- GO:0050702 ! interleukin-1 beta secretion
- GO:0072608 ! interleukin-10 secretion
m
n
- GO:0034140 ! negative regulation of toll-like receptor 3 signaling pathway
- GO:0010804 ! negative regulation of tumor necrosis factor-mediated signaling pathway
- GO:0090198 ! negative regulation of chemokine secretion
- GO:0046329 ! negative regulation of JNK cascade
- GO:0042119 ! neutrophil activation
- GO:0072672 ! neutrophil extravasation
o
- GO:0051482 ! obsolete positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
- GO:0097755 ! obsolete positive regulation of blood vessel diameter
- GO:0014068 ! obsolete positive regulation of phosphatidylinositol 3-kinase signaling
p
- GO:0005886 ! plasma membrane
- GO:0030836 ! positive regulation of actin filament depolymerization
- GO:0030335 ! positive regulation of cell migration
- GO:0043547 ! positive regulation of GTPase activity
- GO:0050927 ! positive regulation of positive chemotaxis
- GO:0002690 ! positive regulation of leukocyte chemotaxis
- GO:2000778 ! positive regulation of interleukin-6 secretion
- GO:2000484 ! positive regulation of interleukin-8 secretion
- GO:1900135 ! positive regulation of renin secretion into blood stream
- GO:0070963 ! positive regulation of neutrophil mediated killing of gram-negative bacterium
- GO:0070374 ! positive regulation of ERK1 and ERK2 cascade
- GO:0060100 ! positive regulation of phagocytosis, engulfment
- GO:0050921 ! positive regulation of chemotaxis
- GO:0046330 ! positive regulation of JNK cascade
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0043311 ! positive regulation of eosinophil degranulation
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:0034137 ! positive regulation of toll-like receptor 2 signaling pathway
- GO:0003104 ! positive regulation of glomerular filtration
- GO:0031274 ! positive regulation of pseudopodium assembly
- GO:0035025 ! positive regulation of Rho protein signal transduction
- GO:0034145 ! positive regulation of toll-like receptor 4 signaling pathway
- GO:0034141 ! positive regulation of toll-like receptor 3 signaling pathway
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0032930 ! positive regulation of superoxide anion generation
- GO:0002741 ! positive regulation of cytokine secretion involved in immune response
- Primates
- GO:0031143 ! pseudopodium
r
s
t