HUMAN:P3C2A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PIK3C2A
Protein Name(s)	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha PI3K-C2-alpha PtdIns-3-kinase C2 subunit alpha Phosphoinositide 3-kinase-C2-alpha
External Links
UniProt	O00443
EMBL	Y13367 AK304262 EU332862 AC107956 AC116533 AC126389 CH471064 BC113658
CCDS	CCDS7824.1
PIR	PC4345
RefSeq	NP_001308307.1 NP_002636.2 XP_016873413.1
UniGene	Hs.175343 Hs.736397
PDB	2AR5 2IWL 2REA 2RED
PDBsum	2AR5 2IWL 2REA 2RED
ProteinModelPortal	O00443
SMR	O00443
BioGrid	111304
CORUM	O00443
DIP	DIP-33727N
ELM	O00443
IntAct	O00443
MINT	MINT-2794824
STRING	9606.ENSP00000265970
BindingDB	O00443
ChEMBL	CHEMBL1075102
GuidetoPHARMACOLOGY	2150
SwissLipids	SLP:000000892
iPTMnet	O00443
PhosphoSitePlus	O00443
BioMuta	PIK3C2A
EPD	O00443
MaxQB	O00443
PaxDb	O00443
PeptideAtlas	O00443
PRIDE	O00443
DNASU	5286
Ensembl	ENST00000265970
GeneID	5286
KEGG	hsa:5286
UCSC	uc001mmq.6
CTD	5286
DisGeNET	5286
EuPathDB	HostDB:ENSG00000011405.13
GeneCards	PIK3C2A
HGNC	HGNC:8971
HPA	HPA037641 HPA037642
MIM	603601
neXtProt	NX_O00443
OpenTargets	ENSG00000011405
PharmGKB	PA33304
eggNOG	KOG0905 COG5032
GeneTree	ENSGT00760000119110
HOGENOM	HOG000006920
HOVERGEN	HBG082099
InParanoid	O00443
KO	K00923
OMA	TIQRGQW
OrthoDB	EOG091G00FC
PhylomeDB	O00443
TreeFam	TF102031
BioCyc	MetaCyc:HS00315-MONOMER
BRENDA	2.7.1.154
Reactome	R-HSA-1660499 R-HSA-1660514 R-HSA-1660516 R-HSA-1660517 R-HSA-432722 R-HSA-8856828
SABIO-RK	O00443
SIGNOR	O00443
ChiTaRS	PIK3C2A
EvolutionaryTrace	O00443
GeneWiki	PIK3C2A
GenomeRNAi	5286
PRO	PR:O00443
Proteomes	UP000005640
Bgee	ENSG00000011405
CleanEx	HS_PIK3C2A
ExpressionAtlas	O00443
Genevisible	O00443
GO	GO:0030136 GO:0005737 GO:0005829 GO:0070062 GO:0005794 GO:0016020 GO:0005634 GO:0005942 GO:0005886 GO:0031982 GO:0016303 GO:0035005 GO:0005524 GO:0035004 GO:0035091 GO:0016477 GO:0048268 GO:0006897 GO:0007173 GO:0006887 GO:0008286 GO:0061024 GO:0014065 GO:0006661 GO:0048008 GO:0014829
Gene3D	1.10.1070.11 2.60.40.150 3.30.1520.10
InterPro	IPR016024 IPR000008 IPR035892 IPR011009 IPR001683 IPR000403 IPR036940 IPR018936 IPR002420 IPR000341 IPR015433 IPR001263 IPR036871 IPR029071
PANTHER	PTHR10048
Pfam	PF00168 PF00454 PF00792 PF00794 PF00613 PF00787
SMART	SM00239 SM00142 SM00144 SM00145 SM00146 SM00312
SUPFAM	SSF48371 SSF49562 SSF54236 SSF56112 SSF64268
PROSITE	PS50004 PS00915 PS00916 PS50290 PS51547 PS51546 PS51545 PS50195

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:26175229^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002619)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:21081650^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:21081650^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21081650^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21081650^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:620899 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P		Seeded From UniProt	complete
	GO:0010508	positive regulation of autophagy	PMID:28910396^[6]	ECO:0000315			P		Fluorescence microscopy was employed to measure the degree of autophagy. Knockdown of PIK3C2A shows a decrease in cellular autophagy as evidenced in Fig 1D showing the fluorescent autophagic punta. Figure 1 and 2	complete CACAO 13067
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015277 FB:FBgn0015278 FB:FBgn0015279 FB:FBgn0267350 MGI:MGI:2448506 PANTHER:PTN000005673 RGD:620916 RGD:620917 SGD:S000004230 SGD:S000004296 SGD:S000005211 UniProtKB:A0A1D8PDV7 UniProtKB:P32871	P		Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1203729 MGI:MGI:2685045 PANTHER:PTN000005674 WB:WBGene00009552	P		Seeded From UniProt	complete
enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 PANTHER:PTN000005674 RGD:620231	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 UniProtKB:O42391	P		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 MGI:MGI:1203729 MGI:MGI:1206581 MGI:MGI:1922019 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P42336	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 PomBase:SPAC458.05 TAIR:locus:2164401 UniProtKB:P48736	C		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015279 PANTHER:PTN000005674 UniProtKB:O00329 UniProtKB:P42338 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1206581 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P32871 WB:WBGene00000090	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 RGD:620231 UniProtKB:O00443 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:621214 UniProtKB:O00443 UniProtKB:P42356 UniProtKB:P48736 WB:WBGene00000090 WB:WBGene00006932 WB:WBGene00009552 dictyBase:DDB_G0291093	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
enables	GO:0035004	phosphatidylinositol 3-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037705	F		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001683 InterPro:IPR036871	F		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015433	P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015433	P		Seeded From UniProt	complete
enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.154	F		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:9337861^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	PMID:9337861^[7] Reactome:R-HSA-1660517 Reactome:R-HSA-1660516 Reactome:R-HSA-1660514 Reactome:R-HSA-1660499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048268	clathrin coat assembly	PMID:17371240^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:17371240^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035004	phosphatidylinositol 3-kinase activity	PMID:17371240^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0014829	vascular smooth muscle contraction	PMID:17371240^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:17371240^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:17371240^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	PMID:17371240^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	Reactome:R-HSA-8868072	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8868072 Reactome:R-HSA-8868071 Reactome:R-HSA-8867754 Reactome:R-HSA-1676206 Reactome:R-HSA-1676109 Reactome:R-HSA-1676024 Reactome:R-HSA-1675961 Reactome:R-HSA-1675939 Reactome:R-HSA-1675928	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0268	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0070	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tang, Y et al. (2015) Role of the microRNA, miR-206, and its target PIK3C2α in endothelial progenitor cell function – potential link with coronary artery disease. FEBS J. 282 3758-72 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Krag, C et al. (2010) PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways. J. Cell. Sci. 123 4240-50 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Merrill, NM et al. (2017) PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles. PLoS ONE 12 e0184909 PubMed GONUTS page
↑ ^7.0 ^7.1 Domin, J et al. (1997) Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem. J. 326 ( Pt 1) 139-47 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Falasca, M & Maffucci, T (2007) Role of class II phosphoinositide 3-kinase in cell signalling. Biochem. Soc. Trans. 35 211-4 PubMed GONUTS page

[PMID:26175229-1] Tang, Y et al. (2015) Role of the microRNA, miR-206, and its target PIK3C2α in endothelial progenitor cell function – potential link with coronary artery disease. FEBS J. 282 3758-72 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:21081650-4] 4.0 ^4.1 ^4.2 ^4.3 Krag, C et al. (2010) PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways. J. Cell. Sci. 123 4240-50 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:28910396-6] Merrill, NM et al. (2017) PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles. PLoS ONE 12 e0184909 PubMed GONUTS page

[PMID:9337861-7] 7.0 ^7.1 Domin, J et al. (1997) Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem. J. 326 ( Pt 1) 139-47 PubMed GONUTS page

[PMID:17371240-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Falasca, M & Maffucci, T (2007) Role of class II phosphoinositide 3-kinase in cell signalling. Biochem. Soc. Trans. 35 211-4 PubMed GONUTS page

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HUMAN:P3C2A

Contents

Annotations

Notes

References

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