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HUMAN:ORC3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ORC3 (synonyms: LATHEO, ORC3L)
Protein Name(s) Origin recognition complex subunit 3

Origin recognition complex subunit Latheo

External Links
UniProt Q9UBD5
EMBL AF135044
AF125507
AF093535
AL080116
AK222795
AK303195
AK315911
AY623113
AL451126
AL133211
AL133211
AL451126
AL451126
AL133211
AL133211
AL451126
BC035494
BC047689
U50950
CCDS CCDS43486.1
CCDS5012.1
CCDS56440.1
PIR T12452
RefSeq NP_001184188.1
NP_036513.2
NP_862820.1
UniGene Hs.410228
ProteinModelPortal Q9UBD5
BioGrid 117130
DIP DIP-31735N
IntAct Q9UBD5
MINT MINT-1201384
PhosphoSite Q9UBD5
DMDM 8928268
MaxQB Q9UBD5
PaxDb Q9UBD5
PRIDE Q9UBD5
DNASU 23595
Ensembl ENST00000257789
ENST00000392844
ENST00000546266
GeneID 23595
KEGG hsa:23595
UCSC uc003pmg.3
uc003pmh.3
CTD 23595
GeneCards GC06P088299
HGNC HGNC:8489
HPA HPA053748
MIM 604972
neXtProt NX_Q9UBD5
PharmGKB PA32810
eggNOG NOG296366
GeneTree ENSGT00390000011376
HOVERGEN HBG007599
InParanoid Q9UBD5
KO K02605
OMA DSLSSWY
OrthoDB EOG78PV8B
PhylomeDB Q9UBD5
TreeFam TF101093
Reactome REACT_1095
REACT_1156
REACT_1181
REACT_1321
REACT_1707
REACT_1949
REACT_207
REACT_2243
REACT_567
REACT_6769
ChiTaRS ORC3
GeneWiki ORC3
ORC3L
GenomeRNAi 23595
NextBio 46252
PRO PR:Q9UBD5
Proteomes UP000005640
Bgee Q9UBD5
ExpressionAtlas Q9UBD5
Genevestigator Q9UBD5
GO GO:0005664
GO:0005654
GO:0000808
GO:0003688
GO:0006260
GO:0000082
GO:0000278
GO:0061351
InterPro IPR020795
PANTHER PTHR12748
Pfam PF07034

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:19135898[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005664

nuclear origin of replication recognition complex

PMID:20932478[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005664

nuclear origin of replication recognition complex

PMID:21029866[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000808

origin recognition complex

PMID:17716973[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031261

DNA replication preinitiation complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000297471
SGD:S000003927

C

Seeded From UniProt

complete

involved_in

GO:0006270

DNA replication initiation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0005654
PANTHER:PTN000297471
SGD:S000003927

P

Seeded From UniProt

complete

involved_in

GO:0006267

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000297471
SGD:S000003927

P

Seeded From UniProt

complete

part_of

GO:0005664

nuclear origin of replication recognition complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0005654
PANTHER:PTN000297471
PomBase:SPAC3H1.01c
SGD:S000003927
UniProtKB:Q9UBD5

C

Seeded From UniProt

complete

part_of

GO:0005656

nuclear pre-replicative complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000297471
SGD:S000003927

C

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000297471
PomBase:SPAC3H1.01c
SGD:S000003927

F

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061351

neural precursor cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JK30
ensembl:ENSMUSP00000048319

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020795

F

Seeded From UniProt

complete

part_of

GO:0005664

nuclear origin of replication recognition complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020795

C

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020795

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

PMID:10402192[6]
Reactome:R-HSA-176318

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

PMID:9829972[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-68944
Reactome:R-HSA-68940
Reactome:R-HSA-68919
Reactome:R-HSA-68918
Reactome:R-HSA-68917
Reactome:R-HSA-68916
Reactome:R-HSA-68849
Reactome:R-HSA-68826
Reactome:R-HSA-68688
Reactome:R-HSA-68615
Reactome:R-HSA-68611
Reactome:R-HSA-68610
Reactome:R-HSA-68603
Reactome:R-HSA-68595
Reactome:R-HSA-176973
Reactome:R-HSA-176318
Reactome:R-HSA-176298

ECO:0000304

author statement supported by traceable reference used in manual assertion

















C

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

Reactome:R-HSA-69206

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
  2. ↑ Shen, Z et al. (2010) A WD-repeat protein stabilizes ORC binding to chromatin. Mol. Cell 40 99-111 PubMed GONUTS page
  3. ↑ Bartke, T et al. (2010) Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143 470-84 PubMed GONUTS page
  4. ↑ Siddiqui, K & Stillman, B (2007) ATP-dependent assembly of the human origin recognition complex. J. Biol. Chem. 282 32370-83 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Pinto, S et al. (1999) latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. Neuron 23 45-54 PubMed GONUTS page
  7. ↑ Tugal, T et al. (1998) The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. J. Biol. Chem. 273 32421-9 PubMed GONUTS page
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