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HUMAN:ORC2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ORC2 (synonyms: ORC2L)
Protein Name(s) Origin recognition complex subunit 2
External Links
UniProt Q13416
EMBL U40268
U27459
AY652588
AC005037
CH471063
BC014834
CCDS CCDS2334.1
RefSeq NP_006181.1
XP_006712618.1
UniGene Hs.444870
ProteinModelPortal Q13416
BioGrid 111041
DIP DIP-29689N
IntAct Q13416
MINT MINT-1201828
STRING 9606.ENSP00000234296
PhosphoSite Q13416
DMDM 8488999
MaxQB Q13416
PaxDb Q13416
PeptideAtlas Q13416
PRIDE Q13416
DNASU 4999
Ensembl ENST00000234296
GeneID 4999
KEGG hsa:4999
UCSC uc002uwr.3
CTD 4999
GeneCards GC02M201774
HGNC HGNC:8488
HPA CAB003693
HPA034976
MIM 601182
neXtProt NX_Q13416
PharmGKB PA32809
eggNOG COG5575
GeneTree ENSGT00390000015228
HOGENOM HOG000045588
HOVERGEN HBG007874
InParanoid Q13416
KO K02604
OMA PVCKETP
OrthoDB EOG7NPFT1
PhylomeDB Q13416
TreeFam TF101092
Reactome REACT_1095
REACT_1156
REACT_1181
REACT_1321
REACT_1707
REACT_1949
REACT_207
REACT_2243
REACT_567
REACT_6769
ChiTaRS ORC2
GeneWiki ORC2
ORC2L
GenomeRNAi 4999
NextBio 19244
PRO PR:Q13416
Proteomes UP000005640
Bgee Q13416
CleanEx HS_ORC2L
ExpressionAtlas Q13416
Genevestigator Q13416
GO GO:0000939
GO:0000792
GO:0016020
GO:0005664
GO:0005654
GO:0005634
GO:0000808
GO:0005886
GO:0003688
GO:0006260
GO:0006270
GO:0000082
GO:0000278
GO:0000122
InterPro IPR007220
PANTHER PTHR14052
Pfam PF04084

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:21383955[1]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000084)

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:19135898[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0000784

nuclear chromosome, telomeric region

PMID:24270157[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000792

heterochromatin

PMID:15215892[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:15215892[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005664

nuclear origin of replication recognition complex

PMID:20932478[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005664

nuclear origin of replication recognition complex

PMID:21029866[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000808

origin recognition complex

PMID:17716973[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005664

nuclear origin of replication recognition complex

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015270
MGI:MGI:1328306
PANTHER:PTN000362151
PomBase:SPBC685.09
SGD:S000000264
UniProtKB:Q13416

C

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1328306
PANTHER:PTN000362151
PomBase:SPBC685.09
SGD:S000000264

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005664

nuclear origin of replication recognition complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60862
ensembl:ENSMUSP00000027198

C

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60862
ensembl:ENSMUSP00000027198

F

Seeded From UniProt

complete

part_of

GO:0000939

condensed chromosome inner kinetochore

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60862
ensembl:ENSMUSP00000027198

C

Seeded From UniProt

complete

part_of

GO:0000792

heterochromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60862
ensembl:ENSMUSP00000027198

C

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60862
ensembl:ENSMUSP00000027198

C

Seeded From UniProt

complete

part_of

GO:0000808

origin recognition complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007220

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007220

C

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007220

P

Seeded From UniProt

complete

involved_in

GO:0006270

DNA replication initiation

PMID:8808289[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8808289[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003688

DNA replication origin binding

PMID:8808289[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

GO:0005813

centrosome

PMID:15215892[4]

ECO:0000314

C

Fig.1

complete
CACAO 6978

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:8808289[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

GO:0000792

heterochromatin

PMID:15215892[4]

ECO:0000314

C

Fig.2

complete
CACAO 6979

involved_in

GO:0006260

DNA replication

Reactome:R-HSA-176318

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-68944
Reactome:R-HSA-68940
Reactome:R-HSA-68919
Reactome:R-HSA-68918
Reactome:R-HSA-68917
Reactome:R-HSA-68916
Reactome:R-HSA-68849
Reactome:R-HSA-68826
Reactome:R-HSA-68688
Reactome:R-HSA-68615
Reactome:R-HSA-68611
Reactome:R-HSA-68610
Reactome:R-HSA-68603
Reactome:R-HSA-68595
Reactome:R-HSA-176973
Reactome:R-HSA-176318
Reactome:R-HSA-176298

ECO:0000304

author statement supported by traceable reference used in manual assertion

















C

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

Reactome:R-HSA-69206

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Bronze-da-Rocha, E et al. (2011) Interactions of MCP1 with components of the replication machinery in mammalian cells. Int. J. Biol. Sci. 7 193-208 PubMed GONUTS page
  2. ↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
  3. ↑ Grolimund, L et al. (2013) A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun 4 2848 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Prasanth, SG et al. (2004) Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J. 23 2651-63 PubMed GONUTS page
  5. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  6. ↑ Shen, Z et al. (2010) A WD-repeat protein stabilizes ORC binding to chromatin. Mol. Cell 40 99-111 PubMed GONUTS page
  7. ↑ Bartke, T et al. (2010) Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143 470-84 PubMed GONUTS page
  8. ↑ Siddiqui, K & Stillman, B (2007) ATP-dependent assembly of the human origin recognition complex. J. Biol. Chem. 282 32370-83 PubMed GONUTS page
  9. ↑ 9.0 9.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 Takahara, K et al. (1996) Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Genomics 31 119-22 PubMed GONUTS page
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