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HUMAN:NUCL

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NCL
Protein Name(s) Nucleolin

Protein C23

External Links
UniProt P19338
EMBL M60858
AK091742
AC017104
CCDS CCDS33397.1
PIR A35804
S53728
RefSeq NP_005372.2
UniGene Hs.79110
PDB 2FC8
2FC9
2KRR
PDBsum 2FC8
2FC9
2KRR
ProteinModelPortal P19338
SMR P19338
BioGrid 110771
DIP DIP-89N
IntAct P19338
MINT MINT-4999081
STRING 9606.ENSP00000318195
PhosphoSite P19338
DMDM 90110781
DOSAC-COBS-2DPAGE P19338
SWISS-2DPAGE P19338
MaxQB P19338
PaxDb P19338
PRIDE P19338
DNASU 4691
Ensembl ENST00000322723
GeneID 4691
KEGG hsa:4691
UCSC uc002vru.3
CTD 4691
GeneCards GC02M232318
HGNC HGNC:7667
HPA CAB004210
HPA023981
MIM 164035
neXtProt NX_P19338
PharmGKB PA31469
eggNOG COG0724
GeneTree ENSGT00730000110998
HOGENOM HOG000113885
HOVERGEN HBG002295
InParanoid P19338
KO K11294
OMA RIGMTRK
OrthoDB EOG73V6KP
PhylomeDB P19338
TreeFam TF328499
ChiTaRS NCL
EvolutionaryTrace P19338
GenomeRNAi 4691
NextBio 18090
PMAP-CutDB P19338
PRO PR:P19338
Proteomes UP000005640
Bgee P19338
CleanEx HS_NCL
ExpressionAtlas P19338
Genevestigator P19338
GO GO:0005938
GO:0036464
GO:0070062
GO:0016020
GO:0005730
GO:0005654
GO:0005634
GO:0030529
GO:0042802
GO:0000166
GO:0044822
GO:0008022
GO:0003723
GO:0042162
GO:0001525
GO:1901838
Gene3D 3.30.70.330
InterPro IPR012677
IPR000504
Pfam PF00076
SMART SM00360
PROSITE PS50102

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005654

nucleoplasm

PMID:23353999[1]

ECO:0000314

C

Figure 3.

complete
CACAO 8160

enables

GO:0044547

DNA topoisomerase binding

PMID:8567649[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P11387

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:23353999[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0017148

negative regulation of translation

PMID:16213212[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0048027

mRNA 5'-UTR binding

PMID:16213212[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15121898[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000031)

Seeded From UniProt

complete

part_of

GO:0036464

cytoplasmic ribonucleoprotein granule

PMID:15121898[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000031)

Seeded From UniProt

complete

involved_in

GO:1901838

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

PMID:24071584[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:24071584[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24071584[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042162

telomeric DNA binding

PMID:8321232[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:17289661[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

PMID:16403913[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P35579

F

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

PMID:16403913[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:19393617[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:8321232[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

PMID:16403913[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001215
FB:FBgn0004237
FB:FBgn0004838
MGI:MGI:1916394
PANTHER:PTN002689974
UniProtKB:P09651
UniProtKB:P19338
UniProtKB:P22626
UniProtKB:Q14103
UniProtKB:Q96EP5
UniProtKB:Q99729

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97286
PANTHER:PTN002690146
RGD:3153
UniProtKB:P19338
UniProtKB:Q9NW13

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104819
MGI:MGI:1330294
MGI:MGI:893588
MGI:MGI:97286
PANTHER:PTN002689974
RGD:1306751
RGD:1310403
RGD:1310906
RGD:3153
RGD:69234
SGD:S000003391
SGD:S000005483
TAIR:locus:2019622
TAIR:locus:2076096
TAIR:locus:2079874
TAIR:locus:2083810
TAIR:locus:2122009
TAIR:locus:2159401
TAIR:locus:2179939
UniProtKB:P19338
UniProtKB:P22626
UniProtKB:P38159
UniProtKB:P62995
UniProtKB:Q03250
UniProtKB:Q13148
UniProtKB:Q14103
UniProtKB:Q9SVM8

F

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:18809582[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:12944467[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21575138[17]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P19338

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1990830

cellular response to leukemia inhibitory factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09405
ensembl:ENSMUSP00000027438

P

Seeded From UniProt

complete

involved_in

GO:0071364

cellular response to epidermal growth factor stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09405
ensembl:ENSMUSP00000027438

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09405
ensembl:ENSMUSP00000027438

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09405
ensembl:ENSMUSP00000027438

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09405
ensembl:ENSMUSP00000027438

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09405
ensembl:ENSMUSP00000027438

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09405
ensembl:ENSMUSP00000027438

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR003954
InterPro:IPR035979

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:2394707[18]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:2737305[19]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Das, S et al. (2013) Characterization of nucleolin K88 acetylation defines a new pool of nucleolin colocalizing with pre-mRNA splicing factors. FEBS Lett. 587 417-24 PubMed GONUTS page
  2. ↑ Bharti, AK et al. (1996) Identification of a nucleolin binding site in human topoisomerase I. J. Biol. Chem. 271 1993-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 Takagi, M et al. (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123 49-63 PubMed GONUTS page
  4. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  5. ↑ 5.0 5.1 Villacé, P et al. (2004) The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res. 32 2411-20 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Cong, R et al. (2014) macroH2A1 histone variant represses rDNA transcription. Nucleic Acids Res. 42 181-92 PubMed GONUTS page
  7. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  8. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  9. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  10. ↑ 10.0 10.1 Ishikawa, F et al. (1993) Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol. Cell. Biol. 13 4301-10 PubMed GONUTS page
  11. ↑ Jønson, L et al. (2007) Molecular composition of IMP1 ribonucleoprotein granules. Mol. Cell Proteomics 6 798-811 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Huang, Y et al. (2006) The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin. Blood 107 3564-71 PubMed GONUTS page
  13. ↑ Li, N et al. (2009) PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression. Biochem. Biophys. Res. Commun. 384 76-81 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  15. ↑ Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page
  16. ↑ Cheng, WH et al. (2003) Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol. Cell. Biol. 23 6385-95 PubMed GONUTS page
  17. ↑ Losfeld, ME et al. (2011) N-Glycosylation influences the structure and self-association abilities of recombinant nucleolin. FEBS J. 278 2552-64 PubMed GONUTS page
  18. ↑ Srivastava, M et al. (1990) Genomic organization and chromosomal localization of the human nucleolin gene. J. Biol. Chem. 265 14922-31 PubMed GONUTS page
  19. ↑ Srivastava, M et al. (1989) Cloning and sequencing of the human nucleolin cDNA. FEBS Lett. 250 99-105 PubMed GONUTS page
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