GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:NSD1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | NSD1 (synonyms: ARA267, KMT3B) | |
| Protein Name(s) | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
Androgen receptor coactivator 267 kDa protein Androgen receptor-associated protein of 267 kDa H3-K36-HMTase H4-K20-HMTase Lysine N-methyltransferase 3B Nuclear receptor-binding SET domain-containing protein 1 NR-binding SET domain-containing protein | |
| External Links | ||
| UniProt | Q96L73 | |
| EMBL | AF380302 AY049721 AF395588 AF322907 | |
| CCDS | CCDS4412.1 CCDS4413.1 | |
| RefSeq | NP_071900.2 NP_758859.1 XP_005266016.1 XP_005266017.1 XP_005266018.1 XP_006714964.1 XP_006714965.1 | |
| UniGene | Hs.106861 | |
| PDB | 3OOI | |
| PDBsum | 3OOI | |
| ProteinModelPortal | Q96L73 | |
| SMR | Q96L73 | |
| BioGrid | 122135 | |
| DIP | DIP-58517N | |
| IntAct | Q96L73 | |
| STRING | 9606.ENSP00000348031 | |
| PhosphoSite | Q96L73 | |
| DMDM | 32469769 | |
| MaxQB | Q96L73 | |
| PaxDb | Q96L73 | |
| PRIDE | Q96L73 | |
| Ensembl | ENST00000347982 ENST00000354179 ENST00000439151 | |
| GeneID | 64324 | |
| KEGG | hsa:64324 | |
| UCSC | uc003mfr.4 uc003mfs.1 uc003mft.4 | |
| CTD | 64324 | |
| GeneCards | GC05P176560 | |
| GeneReviews | NSD1 | |
| HGNC | HGNC:14234 | |
| MIM | 117550 130650 606681 | |
| neXtProt | NX_Q96L73 | |
| Orphanet | 228415 238613 821 3447 | |
| PharmGKB | PA31790 | |
| eggNOG | COG2940 | |
| GeneTree | ENSGT00760000118855 | |
| HOGENOM | HOG000113857 | |
| HOVERGEN | HBG007518 | |
| InParanoid | Q96L73 | |
| KO | K15588 | |
| OMA | ECRTGIH | |
| OrthoDB | EOG7Z69BG | |
| PhylomeDB | Q96L73 | |
| TreeFam | TF329088 | |
| ChiTaRS | NSD1 | |
| GenomeRNAi | 64324 | |
| NextBio | 66241 | |
| PRO | PR:Q96L73 | |
| Proteomes | UP000005640 | |
| Bgee | Q96L73 | |
| CleanEx | HS_NSD1 | |
| ExpressionAtlas | Q96L73 | |
| Genevestigator | Q96L73 | |
| GO | GO:0005694 GO:0005634 GO:0050681 GO:0003682 GO:0030331 GO:0046975 GO:0042799 GO:0042974 GO:0046965 GO:0046966 GO:0003712 GO:0003714 GO:0008270 GO:0001702 GO:0010452 GO:0034770 GO:0016571 GO:0000122 GO:0045893 GO:0006351 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR006560 IPR003616 IPR000313 IPR001214 IPR019786 IPR011011 IPR001965 IPR019787 IPR001841 IPR013083 | |
| Pfam | PF00628 PF00855 PF00856 | |
| SMART | SM00570 SM00249 SM00508 SM00293 SM00184 SM00317 | |
| SUPFAM | SSF57903 | |
| PROSITE | PS51215 PS50868 PS50812 PS50280 PS01359 PS50016 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0050681 |
androgen receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046975 |
histone methyltransferase activity (H3-K36 specific) |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046975 |
histone methyltransferase activity (H3-K36 specific) |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046966 |
thyroid hormone receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046965 |
retinoid X receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042974 |
retinoic acid receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042799 |
histone methyltransferase activity (H4-K20 specific) |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030331 |
estrogen receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016571 |
histone methylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003712 |
transcription coregulator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046975 |
histone methyltransferase activity (H3-K36 specific) |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0030486 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1276545 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0030486 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000785 |
chromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0039559 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903025 |
regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033135 |
regulation of peptidyl-serine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000414 |
regulation of histone H3-K36 methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010452 |
histone H3-K36 methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046975 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010452 |
histone H3-K36 methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046975 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010452 |
histone H3-K36 methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046975 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034770 |
histone H4-K20 methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0042799 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034968 |
histone lysine methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0018024 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034968 |
histone lysine methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0018024 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5638157 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Wang, X et al. (2001) Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells. J. Biol. Chem. 276 40417-23 PubMed GONUTS page
- ↑ 2.0 2.1 Qiao, Q et al. (2011) The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. J. Biol. Chem. 286 8361-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Lucio-Eterovic, AK et al. (2010) Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function. Proc. Natl. Acad. Sci. U.S.A. 107 16952-7 PubMed GONUTS page
c
h
m
n
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0050681 ! nuclear androgen receptor binding
- GO:0030331 ! nuclear estrogen receptor binding
- GO:0046965 ! nuclear retinoid X receptor binding
- GO:0042974 ! nuclear retinoic acid receptor binding
- GO:0046966 ! nuclear thyroid hormone receptor binding
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
- GO:0018024 ! obsolete histone lysine N-methyltransferase activity
- GO:0016571 ! obsolete histone methylation
- GO:0034968 ! obsolete histone lysine methylation
- GO:0034770 ! obsolete histone H4-K20 methylation
- GO:0010452 ! obsolete histone H3-K36 methylation
- GO:0000414 ! obsolete regulation of histone H3-K36 methylation
r
t
