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HUMAN:NS1BP
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | IVNS1ABP (synonyms: ARA3, FLARA3, KIAA0850, NS1, NS1BP) | |
| Protein Name(s) | Influenza virus NS1A-binding protein
NS1-BP NS1-binding protein Aryl hydrocarbon receptor-associated protein 3 | |
| External Links | ||
| UniProt | Q9Y6Y0 | |
| EMBL | AJ012449 DQ443528 DQ443529 AF205218 AB020657 AF161553 AL078644 AL356273 AK292431 AL078644 AL356273 AL078644 CH471067 BC067739 | |
| CCDS | CCDS1368.1 | |
| RefSeq | NP_006460.2 | |
| UniGene | Hs.497183 | |
| ProteinModelPortal | Q9Y6Y0 | |
| SMR | Q9Y6Y0 | |
| BioGrid | 115869 | |
| IntAct | Q9Y6Y0 | |
| MINT | MINT-1371090 | |
| PhosphoSite | Q9Y6Y0 | |
| DMDM | 146325015 | |
| MaxQB | Q9Y6Y0 | |
| PaxDb | Q9Y6Y0 | |
| PRIDE | Q9Y6Y0 | |
| Ensembl | ENST00000367498 | |
| GeneID | 10625 | |
| KEGG | hsa:10625 | |
| UCSC | uc001grl.3 | |
| CTD | 10625 | |
| GeneCards | GC01M185265 | |
| HGNC | HGNC:16951 | |
| HPA | HPA003405 | |
| MIM | 609209 | |
| neXtProt | NX_Q9Y6Y0 | |
| PharmGKB | PA134875300 | |
| eggNOG | NOG236155 | |
| GeneTree | ENSGT00760000119153 | |
| HOVERGEN | HBG082407 | |
| InParanoid | Q9Y6Y0 | |
| KO | K15046 | |
| OMA | KLWTSCA | |
| OrthoDB | EOG7327N7 | |
| PhylomeDB | Q9Y6Y0 | |
| TreeFam | TF329218 | |
| ChiTaRS | IVNS1ABP | |
| GeneWiki | IVNS1ABP | |
| GenomeRNAi | 10625 | |
| NextBio | 40368 | |
| PRO | PR:Q9Y6Y0 | |
| Proteomes | UP000005640 | |
| Bgee | Q9Y6Y0 | |
| CleanEx | HS_IVNS1ABP | |
| ExpressionAtlas | Q9Y6Y0 | |
| Genevestigator | Q9Y6Y0 | |
| GO | GO:0005737 GO:0005856 GO:0005654 GO:0005681 GO:0005667 GO:2001243 GO:0009615 GO:0008380 GO:0006383 GO:0016032 | |
| Gene3D | 2.130.10.80 | |
| InterPro | IPR011705 IPR000210 IPR011333 IPR013069 IPR015916 IPR017096 IPR006652 IPR029849 | |
| PANTHER | PTHR24411:SF7 | |
| Pfam | PF07707 PF00651 PF01344 | |
| PIRSF | PIRSF037037 | |
| SMART | SM00875 SM00225 SM00612 | |
| SUPFAM | SSF54695 | |
| PROSITE | PS50097 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044419 |
interspecies interaction between organisms |
ECO:0000314 |
P |
Figure 4 shows the uninfected distribution of the NS1 protein outside of the cell, then the accumulation of the NS1 protein in the infected cells, indicating that the virus binds to the NS1 protein. |
complete | |||||
| GO:0005730 |
nucleolus |
ECO:0000314 |
C |
Figure 5 shows nucleolus localization. |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000304 |
C |
In the result,second to last sentence, the author writes that Figure 2 (a and b) shows that the NS1 protein is localized in the nucleus. |
complete | |||||
|
involved_in |
GO:0031397 |
negative regulation of protein ubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009615 |
response to virus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920Q8 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q920Q8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0015629 |
actin cytoskeleton |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009615 |
response to virus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006383 |
transcription by RNA polymerase III |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005681 |
spliceosomal complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Wolff, T et al. (1998) NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. J. Virol. 72 7170-80 PubMed GONUTS page
- ↑ Melén, K et al. (2012) Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin. Virol. J. 9 167 PubMed GONUTS page
- ↑ Greenspan, D et al. (1988) Two nuclear location signals in the influenza virus NS1 nonstructural protein. J. Virol. 62 3020-6 PubMed GONUTS page
- ↑ Chen, HY et al. (2015) KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination. Oncogene 34 5141-51 PubMed GONUTS page
- ↑ 5.0 5.1 Tsai, PL et al. (2013) Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing. PLoS Pathog. 9 e1003460 PubMed GONUTS page
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