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PMID:22909121
| Citation |
Melén, K, Tynell, J, Fagerlund, R, Roussel, P, Hernandez-Verdun, D and Julkunen, I (2012) Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin. Virol. J. 9:167 |
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| Abstract |
Influenza A virus non-structural protein 1 (NS1) is a virulence factor, which is targeted into the cell cytoplasm, nucleus and nucleolus. NS1 is a multi-functional protein that inhibits host cell pre-mRNA processing and counteracts host cell antiviral responses. Previously, we have shown that the NS1 protein of the H3N2 subtype influenza viruses possesses a C-terminal nuclear localization signal (NLS) that also functions as a nucleolar localization signal (NoLS) and targets the protein into the nucleolus. |
| Links |
PubMed PMC3493336 Online version:10.1186/1743-422X-9-167 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005730: nucleolus |
ECO:0000314: |
C |
Figure 5 shows nucleolus localization. |
complete | ||||
See also
References
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