HUMAN:NRX1B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NRXN1
Protein Name(s)	Neurexin-1-beta Neurexin I-beta
External Links
UniProt	P58400
EMBL	AF064842 AC068725 AC069550 AC078994
CCDS	CCDS1845.1
RefSeq	NP_620072.1
UniGene	Hs.637685
PDB	3B3Q
PDBsum	3B3Q
ProteinModelPortal	P58400
SMR	P58400
BioGrid	114779
DIP	DIP-46402N
STRING	9606.ENSP00000385142
DMDM	322510054
PRIDE	P58400
Ensembl	ENST00000342183
GeneID	9378
KEGG	hsa:9378
UCSC	uc010fbp.3
CTD	9378
GeneCards	GC02M050145
HGNC	HGNC:8008
MIM	600565
neXtProt	NX_P58400
Orphanet	106 221150 3140
GeneTree	ENSGT00760000118991
HOGENOM	HOG000230482
HOVERGEN	HBG052670
KO	K07377
ChiTaRS	NRXN1
EvolutionaryTrace	P58400
GeneWiki	NRXN1
GenomeRNAi	9378
NextBio	35134
PRO	PR:P58400
Proteomes	UP000005640
Bgee	P58400
CleanEx	HS_NRXN1
ExpressionAtlas	P58400
Genevestigator	P58400
GO	GO:0044295 GO:0030054 GO:0009986 GO:0030139 GO:0016021 GO:0005886 GO:0042734 GO:0048306 GO:0050839 GO:0046872 GO:0097109 GO:0005102 GO:0030534 GO:0001525 GO:0016339 GO:0021707 GO:0045184 GO:0097112 GO:0097116 GO:0097117 GO:0007157 GO:0007612 GO:0097114 GO:0051490 GO:0097118 GO:0007158 GO:0023041 GO:0090004 GO:2000463 GO:0051968 GO:0097119 GO:0097104 GO:0097105 GO:0090126 GO:0035418 GO:0097120 GO:2000311 GO:2000310 GO:0035176 GO:0007416 GO:0007268 GO:0097091 GO:0071625
Gene3D	2.60.120.200
InterPro	IPR013320 IPR001791 IPR029824 IPR003585 IPR027789
PANTHER	PTHR10127:SF565
Pfam	PF02210 PF01034
SMART	SM00294 SM00282
SUPFAM	SSF49899
PROSITE	PS50025

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	PMID:22750515^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P11362)	Seeded From UniProt	complete
enables	GO:0005105	type 1 fibroblast growth factor receptor binding	PMID:22750515^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	positively_regulates:(GO:0018108)	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:22750515^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q62765	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	P		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	F	part_of:(GO:0071277)	Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	PMID:14522992^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	occurs_in:(GO:0045202) occurs_in:(GO:0005615)	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:14522992^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:26078884^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:26078884^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0010739	positive regulation of protein kinase A signaling	PMID:26078884^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q05586) regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:1900020	positive regulation of protein kinase C activity	PMID:26078884^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q05586) regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:26078884^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q05586) regulates_o_occurs_in:(CL:0002609) regulates:(GO:0004697) regulates:(GO:0010737)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:26078884^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000136238) regulates_o_occurs_in:(CL:0002609)\|regulates_expression_of(ENSEMBL:ENSG00000170345) regulates_o_occurs_in:(CL:0002609)\|regulates_expression_of(ENSEMBL:ENSG00000176884) regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:26078884^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000162946)	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(UBERON:0014554)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
involved_in	GO:0090126	protein-containing complex assembly involved in synapse maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097117	guanylate kinase-associated protein clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097112	gamma-aminobutyric acid receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	F		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0071625	vocalization behavior	PMID:17034946^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0051490	negative regulation of filopodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	F		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	F		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	F		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	C		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:17034946^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030534	adult behavior	PMID:17034946^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	C		Seeded From UniProt	complete
involved_in	GO:0021707	cerebellar granule cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	C		Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:17034946^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DI97	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D0PRN2	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037440	C		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:15797875^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	PMID:15797875^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905520	positive regulation of presynaptic active zone assembly	PMID:15797875^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:15797875^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0023041	neuronal signal transduction	PMID:15797875^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:15797875^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6797974 Reactome:R-HSA-6797568 Reactome:R-HSA-6797554 Reactome:R-HSA-6794346	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0222	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Gjørlund, MD et al. (2012) Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1β and activation of fibroblast growth factor receptor-1. FASEB J. 26 4174-86 PubMed GONUTS page
↑ ^2.0 ^2.1 Comoletti, D et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J. Biol. Chem. 278 50497-505 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Owczarek, S et al. (2015) Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 "Signalosome". Neural Plast. 2015 167308 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Feng, J et al. (2006) High frequency of neurexin 1beta signal peptide structural variants in patients with autism. Neurosci. Lett. 409 10-3 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Chubykin, AA et al. (2005) Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J. Biol. Chem. 280 22365-74 PubMed GONUTS page

[PMID:22750515-1] 1.0 ^1.1 ^1.2 Gjørlund, MD et al. (2012) Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1β and activation of fibroblast growth factor receptor-1. FASEB J. 26 4174-86 PubMed GONUTS page

[PMID:14522992-2] 2.0 ^2.1 Comoletti, D et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J. Biol. Chem. 278 50497-505 PubMed GONUTS page

[PMID:26078884-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Owczarek, S et al. (2015) Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 "Signalosome". Neural Plast. 2015 167308 PubMed GONUTS page

[PMID:17034946-4] 4.0 ^4.1 ^4.2 ^4.3 Feng, J et al. (2006) High frequency of neurexin 1beta signal peptide structural variants in patients with autism. Neurosci. Lett. 409 10-3 PubMed GONUTS page

[PMID:15797875-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Chubykin, AA et al. (2005) Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J. Biol. Chem. 280 22365-74 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

HUMAN:NRX1B

Contents

Annotations

Notes

References

a

c

d

e

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools