HUMAN:NOX1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NOX1 (synonyms: MOX1, NOH1)
Protein Name(s)	NADPH oxidase 1 NOX-1 Mitogenic oxidase 1 MOX-1 NADH/NADPH mitogenic oxidase subunit P65-MOX NOH-1
External Links
UniProt	Q9Y5S8
EMBL	AF127763 AF166326 AF166327 AF166328 DQ314883 AK292201 Z83819 Z83819 CH471115 BC075014 BC075015
CCDS	CCDS14474.1 CCDS14475.1
RefSeq	NP_001258744.1 NP_008983.2 NP_039249.1
UniGene	Hs.592227
ProteinModelPortal	Q9Y5S8
SMR	Q9Y5S8
BioGrid	117966
DIP	DIP-60457N
STRING	9606.ENSP00000362057
BindingDB	Q9Y5S8
ChEMBL	CHEMBL1287628
PeroxiBase	5410
TCDB	5.B.1.1.3
PhosphoSite	Q9Y5S8
DMDM	8134597
PaxDb	Q9Y5S8
PRIDE	Q9Y5S8
Ensembl	ENST00000217885 ENST00000372966
GeneID	27035
KEGG	hsa:27035
UCSC	uc004egj.3 uc004egl.4
CTD	27035
GeneCards	GC0XM100098
HGNC	HGNC:7889
HPA	HPA035299 HPA035300
MIM	300225
neXtProt	NX_Q9Y5S8
PharmGKB	PA31690
eggNOG	NOG287712
GeneTree	ENSGT00550000074350
HOGENOM	HOG000216669
HOVERGEN	HBG003760
InParanoid	Q9Y5S8
KO	K08008
OMA	IATSHPK
OrthoDB	EOG71P299
PhylomeDB	Q9Y5S8
TreeFam	TF105354
ChiTaRS	NOX1
GeneWiki	NOX1
GenomeRNAi	27035
NextBio	49586
PRO	PR:Q9Y5S8
Proteomes	UP000005640
Bgee	Q9Y5S8
CleanEx	HS_NOX1
ExpressionAtlas	Q9Y5S8
Genevestigator	Q9Y5S8
GO	GO:0030054 GO:0005769 GO:0016021 GO:0071438 GO:0043020 GO:0046872 GO:0050661 GO:0048365 GO:0016175 GO:0030171 GO:0001525 GO:0016477 GO:0071455 GO:1990451 GO:0030198 GO:0042743 GO:0006954 GO:0051454 GO:0006739 GO:0055114 GO:0072592 GO:0008284 GO:0045726 GO:0046330 GO:1902177 GO:0048661 GO:0010575 GO:0015992 GO:0008217 GO:0003081 GO:0045730 GO:0007165 GO:0042554 GO:0006801
InterPro	IPR000778 IPR013112 IPR017927 IPR013130 IPR013121 IPR029650 IPR017938
PANTHER	PTHR11972:SF10
Pfam	PF08022 PF01794 PF08030
PRINTS	PR00466
SUPFAM	SSF63380
PROSITE	PS51384

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:18023288^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1990451	cellular stress response to acidic pH	PMID:10615049^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:10615049^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051454	intracellular pH elevation	PMID:10615049^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:10485709^[3]	ECO:0000305	curator inference used in manual assertion	GO:0042554	F	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:10485709^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV87	P	Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:16636067^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63000	F	Seeded From UniProt	complete
involved_in	GO:0045726	positive regulation of integrin biosynthetic process	PMID:18023288^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043020	NADPH oxidase complex	PMID:16636067^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042743	hydrogen peroxide metabolic process	PMID:11331784^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:10485709^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:18023288^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:10485709^[3]	ECO:0000305	curator inference used in manual assertion	GO:0042554	F	Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:11805326^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10485709^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:18023288^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006739	NADP metabolic process	PMID:10485709^[3]	ECO:0000305	curator inference used in manual assertion	GO:0042554	P	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:17673675^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:11805326^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0071438	invadopodium membrane	PMID:19755710^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN001735877 PomBase:SPBC1683.09c RGD:620600 SGD:S000003128 SGD:S000004037 SGD:S000005512 TAIR:locus:2017789 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2025366 TAIR:locus:2157032 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 TAIR:locus:2178677 TAIR:locus:2178687 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9NPH5 UniProtKB:Q9NRD8 UniProtKB:Q9SBI0 UniProtKB:Q9Y5S8 WB:WBGene00000253 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	P	Seeded From UniProt	complete
part_of	GO:0043020	NADPH oxidase complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN000239643 RGD:620574 RGD:620598 RGD:620600 UniProtKB:P04839 UniProtKB:Q9Y5S8	C	Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 RGD:620598 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101	P	Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	F	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:88574 PANTHER:PTN000239643 UniProtKB:P04839 ZFIN:ZDB-GENE-091117-14 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653 dictyBase:DDB_G0291117	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2139422 MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN001735877 RGD:620574 RGD:620598 RGD:620600 SGD:S000005512 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2157027 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 UniProtKB:O81209 UniProtKB:P04839 UniProtKB:Q9Y5S8 WB:WBGene00000253	C	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005244	P	Seeded From UniProt	complete
involved_in	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	P	Seeded From UniProt	complete
involved_in	GO:0072592	oxygen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	P	Seeded From UniProt	complete
involved_in	GO:0071455	cellular response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	P	Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	P	Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	P	Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	F	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	C	Seeded From UniProt	complete
involved_in	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CIZ9 ensembl:ENSMUSP00000033610	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000778	C	Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029650	F	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000778 InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	F	Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029650	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000778 InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	P	Seeded From UniProt	complete
involved_in	GO:0045730	respiratory burst	PMID:16636067^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:18347018^[10] PMID:10485709^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	PMID:18347018^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:17673675^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:18347018^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5668718 Reactome:R-HSA-5668714	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560 UniProtKB-KW:KW-0249	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0071438	invadopodium membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0290	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Sadok, A et al. (2008) Nox1-dependent superoxide production controls colon adenocarcinoma cell migration. Biochim. Biophys. Acta 1783 23-33 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Bánfi, B et al. (2000) A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science 287 138-42 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Suh, YA et al. (1999) Cell transformation by the superoxide-generating oxidase Mox1. Nature 401 79-82 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Cheng, G et al. (2006) Nox1-dependent reactive oxygen generation is regulated by Rac1. J. Biol. Chem. 281 17718-26 PubMed GONUTS page
↑ Arnold, RS et al. (2001) Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc. Natl. Acad. Sci. U.S.A. 98 5550-5 PubMed GONUTS page
↑ ^6.0 ^6.1 Arbiser, JL et al. (2002) Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc. Natl. Acad. Sci. U.S.A. 99 715-20 PubMed GONUTS page
↑ ^7.0 ^7.1 Miller, FJ Jr et al. (2007) Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. Circ. Res. 101 663-71 PubMed GONUTS page
↑ Gianni, D et al. (2009) Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal 2 ra54 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Kao, YY et al. (2008) Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism. J. Biol. Chem. 283 12736-46 PubMed GONUTS page

[PMID:18023288-1] 1.0 ^1.1 ^1.2 ^1.3 Sadok, A et al. (2008) Nox1-dependent superoxide production controls colon adenocarcinoma cell migration. Biochim. Biophys. Acta 1783 23-33 PubMed GONUTS page

[PMID:10615049-2] 2.0 ^2.1 ^2.2 Bánfi, B et al. (2000) A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science 287 138-42 PubMed GONUTS page

[PMID:10485709-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Suh, YA et al. (1999) Cell transformation by the superoxide-generating oxidase Mox1. Nature 401 79-82 PubMed GONUTS page

[PMID:16636067-4] 4.0 ^4.1 ^4.2 Cheng, G et al. (2006) Nox1-dependent reactive oxygen generation is regulated by Rac1. J. Biol. Chem. 281 17718-26 PubMed GONUTS page

[PMID:11331784-5] Arnold, RS et al. (2001) Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc. Natl. Acad. Sci. U.S.A. 98 5550-5 PubMed GONUTS page

[PMID:11805326-6] 6.0 ^6.1 Arbiser, JL et al. (2002) Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc. Natl. Acad. Sci. U.S.A. 99 715-20 PubMed GONUTS page

[PMID:17673675-7] 7.0 ^7.1 Miller, FJ Jr et al. (2007) Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. Circ. Res. 101 663-71 PubMed GONUTS page

[PMID:19755710-8] Gianni, D et al. (2009) Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal 2 ra54 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18347018-10] 10.0 ^10.1 ^10.2 Kao, YY et al. (2008) Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism. J. Biol. Chem. 283 12736-46 PubMed GONUTS page

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HUMAN:NOX1

Contents

Annotations

Notes

References

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