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PMID:10615049
| Citation |
Bánfi, B, Maturana, A, Jaconi, S, Arnaudeau, S, Laforge, T, Sinha, B, Ligeti, E, Demaurex, N and Krause, KH (2000) A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science 287:138-42 |
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| Abstract |
Voltage-gated proton (H+) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191-amino acid protein is described that, upon heterologous expression, has properties indistinguishable from those of native H+ channels. This protein is generated through alternative splicing of messenger RNA derived from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate). |
| Links | |
| Keywords |
Alternative Splicing; Amino Acid Sequence; Cell Line; Cytosol/metabolism; Electric Conductivity; Electron Transport; Expressed Sequence Tags; Humans; Hydrogen/metabolism; Hydrogen-Ion Concentration; Ion Channel Gating; Ion Channels/chemistry; Ion Channels/genetics; Ion Channels/metabolism; Membrane Glycoproteins/chemistry; Membrane Glycoproteins/genetics; Molecular Sequence Data; NADPH Oxidase/chemistry; NADPH Oxidase/genetics; Patch-Clamp Techniques; Protons; Transfection; Tumor Cells, Cultured; Zinc/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1990451: cellular stress response to acidic pH |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114: oxidation-reduction process |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051454: intracellular pH elevation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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