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HUMAN:NKG2D

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KLRK1 (synonyms: D12S2489E, NKG2D)
Protein Name(s) NKG2-D type II integral membrane protein

Killer cell lectin-like receptor subfamily K member 1 NK cell receptor D NKG2-D-activating NK receptor

External Links
UniProt P26718
EMBL X54870
AJ001687
AJ001688
AJ001689
AF461811
AF260135
AF260136
AK292059
AK292020
AC022075
CH471094
BC039836
CCDS CCDS8623.1
PIR PT0375
RefSeq NP_001186734.1
NP_031386.2
UniGene Hs.387787
PDB 1HYR
1KCG
1MPU
4PDC
PDBsum 1HYR
1KCG
1MPU
4PDC
ProteinModelPortal P26718
SMR P26718
BioGrid 116576
DIP DIP-31100N
IntAct P26718
MINT MINT-8289618
STRING 9606.ENSP00000240618
PhosphoSite P26718
DMDM 128370
MaxQB P26718
PaxDb P26718
PRIDE P26718
Ensembl ENST00000240618
ENST00000540818
GeneID 100528032
22914
KEGG hsa:100528032
hsa:22914
UCSC uc001qyc.3
CTD 100528032
22914
GeneCards GC12M010524
H-InvDB HIX0020427
HGNC HGNC:18788
HPA CAB021896
MIM 611817
neXtProt NX_P26718
PharmGKB PA128394594
eggNOG NOG315914
HOGENOM HOG000220925
HOVERGEN HBG052629
InParanoid P26718
KO K06728
PhylomeDB P26718
TreeFam TF336674
Reactome REACT_11152
REACT_147694
REACT_147814
EvolutionaryTrace P26718
GeneWiki KLRK1
NextBio 43595
PRO PR:P26718
Proteomes UP000005640
Bgee P26718
CleanEx HS_KLRK1
ExpressionAtlas P26718
Genevestigator P26718
GO GO:0009986
GO:0016021
GO:0005887
GO:0005886
GO:0030246
GO:0004872
GO:0030154
GO:0045087
GO:0030101
GO:0045954
GO:0050776
GO:0007165
GO:0031295
Gene3D 3.10.100.10
InterPro IPR001304
IPR016186
IPR016187
Pfam PF00059
SMART SM00034
SUPFAM SSF56436
PROSITE PS50041

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:2000502

negative regulation of natural killer cell chemotaxis

PMID:22585739[1]

ECO:0000314

P

Fig 1A shows that the presence of NKG2D caused a smaller percent of the activated NK-cells to migrate toward a CXCL12 gradient.

complete
CACAO 5737

GO:0034260

negative regulation of GTPase activity

PMID:22585739[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Fig 4A shows that when NKG2D is activated, Rho A activity decreases.

complete
CACAO 5740

part_of

GO:0005886

plasma membrane

PMID:17562706[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:17562706[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042267

natural killer cell mediated cytotoxicity

PMID:17562706[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034260

negative regulation of GTPase activity

PMID:22585739[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000502

negative regulation of natural killer cell chemotaxis

PMID:22585739[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

PMID:15294961[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:10426994[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:15294961[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1196250
PANTHER:PTN000514058
RGD:3180
UniProtKB:P26718

P

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1196250
PANTHER:PTN000514058
UniProtKB:P26718

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1196250
PANTHER:PTN000514058
RGD:3180
UniProtKB:P26718

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1196250
PANTHER:PTN000514058

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

P

Seeded From UniProt

complete

involved_in

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

P

Seeded From UniProt

complete

involved_in

GO:0045429

positive regulation of nitric oxide biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

F

Seeded From UniProt

complete

enables

GO:0042288

MHC class I protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

F

Seeded From UniProt

complete

involved_in

GO:0032729

positive regulation of interferon-gamma production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

P

Seeded From UniProt

complete

enables

GO:0032394

MHC class Ib receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

F

Seeded From UniProt

complete

involved_in

GO:0030101

natural killer cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

C

Seeded From UniProt

complete

involved_in

GO:0002223

stimulatory C-type lectin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54709
ensembl:ENSMUSP00000032252

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:9683661[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:2007850[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:2007850[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:2007850[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0031295

T cell costimulation

PMID:18676862[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030101

natural killer cell activation

PMID:18676862[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050776

regulation of immune response

Reactome:R-HSA-198933

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-2424487
Reactome:R-HSA-2424486
Reactome:R-HSA-2424484
Reactome:R-HSA-2424482
Reactome:R-HSA-2424480
Reactome:R-HSA-2396594
Reactome:R-HSA-2395801
Reactome:R-HSA-2395412
Reactome:R-HSA-210289
Reactome:R-HSA-198983

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0430

F

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Serrano-Pertierra, E et al. (2012) Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. Eur. J. Immunol. 42 2142-51 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Hoffmann, SC et al. (2007) Identification of CLEC12B, an inhibitory receptor on myeloid cells. J. Biol. Chem. 282 22370-5 PubMed GONUTS page
  3. ↑ 3.0 3.1 Rosen, DB et al. (2004) A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. J. Immunol. 173 2470-8 PubMed GONUTS page
  4. ↑ Wu, J et al. (1999) An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285 730-2 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Glienke, J et al. (1998) The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. Immunogenetics 48 163-73 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Houchins, JP et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173 1017-20 PubMed GONUTS page
  8. ↑ 8.0 8.1 Waldhauer, I et al. (2008) Tumor-associated MICA is shed by ADAM proteases. Cancer Res. 68 6368-76 PubMed GONUTS page
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