HUMAN:NEU1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	OXT (synonyms: OT)
Protein Name(s)	Oxytocin-neurophysin 1 OT-NPI Oxytocin Ocytocin Neurophysin 1
External Links
UniProt	P01178
EMBL	M25650 M11186 AY082910 AL160414 BC069144 BC101841 BC101843 X03173 M62611
CCDS	CCDS13044.1
PIR	A94676
RefSeq	NP_000906.1
UniGene	Hs.113216
ProteinModelPortal	P01178
SMR	P01178
BioGrid	111060
IntAct	P01178
STRING	9606.ENSP00000217386
DrugBank	DB00107
DMDM	128071
PaxDb	P01178
PeptideAtlas	P01178
PRIDE	P01178
Ensembl	ENST00000217386
GeneID	5020
KEGG	hsa:5020
UCSC	uc002wht.1
CTD	5020
GeneCards	GC20P003064
HGNC	HGNC:8528
MIM	167050
neXtProt	NX_P01178
PharmGKB	PA32857
eggNOG	NOG44533
HOGENOM	HOG000113768
HOVERGEN	HBG004462
InParanoid	P01178
KO	K05243
OMA	DGCRTDP
OrthoDB	EOG7NW6C5
PhylomeDB	P01178
TreeFam	TF333018
Reactome	REACT_17041 REACT_18283
GeneWiki	Neurophysin_I Oxytocin
GenomeRNAi	5020
NextBio	19328
PMAP-CutDB	P01178
PRO	PR:P01178
Proteomes	UP000005640
Bgee	P01178
CleanEx	HS_OXT
ExpressionAtlas	P01178
Genevestigator	P01178
GO	GO:0005576 GO:0005615 GO:0030141 GO:0043195 GO:0042756 GO:0042755 GO:0007565 GO:0007625 GO:0007507 GO:0042538 GO:0060179 GO:0002125 GO:0042711 GO:0007613 GO:0045776 GO:0060455 GO:0035811 GO:0045777 GO:0007204 GO:0045925 GO:0060450 GO:0010701 GO:0045778 GO:0060406 GO:0032308 GO:0035815 GO:0051965 GO:0050806 GO:0070474 GO:0002027 GO:0051930 GO:0014823 GO:0001975 GO:0051591 GO:0042220 GO:0051602 GO:0032355 GO:0045472 GO:0032094 GO:0051384 GO:0043434 GO:0032570 GO:0034695 GO:0032526 GO:0009744 GO:0007165 GO:0030431 GO:0035176 GO:0042713
Gene3D	2.60.9.10
InterPro	IPR000981 IPR022423
PANTHER	PTHR11681
Pfam	PF00220 PF00184
PIRSF	PIRSF001815
PRINTS	PR00831
ProDom	PD001676
SMART	SM00003
SUPFAM	SSF49606
PROSITE	PS00264

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0065009	regulation of molecular function	PMID:23889750^[1]	ECO:0000315			P	Figure 5	complete CACAO 9533
	GO:0090303	positive regulation of wound healing	PMID:24205344^[2]	ECO:0000315			P	Figure 6 & 7	complete CACAO 9538
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:18071238^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35454	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005185	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0070474	positive regulation of uterine smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0060455	negative regulation of gastric acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0060450	positive regulation of hindgut contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0060406	positive regulation of penile erection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0060179	male mating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0045925	positive regulation of female receptivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0045777	positive regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0045472	response to ether	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0044058	regulation of digestive system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	C	Seeded From UniProt	complete
involved_in	GO:0042756	drinking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0042713	sperm ejaculation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0042711	maternal behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0042538	hyperosmotic salinity response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0035815	positive regulation of renal sodium excretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0035811	negative regulation of urine volume	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0034695	response to prostaglandin E	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0032308	positive regulation of prostaglandin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0032094	response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
enables	GO:0031855	oxytocin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	F	Seeded From UniProt	complete
involved_in	GO:0030431	sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	C	Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0010701	positive regulation of norepinephrine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0009744	response to sucrose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0007625	grooming behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	C	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	F	Seeded From UniProt	complete
involved_in	GO:0002125	maternal aggressive behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0002027	regulation of heart rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01179 ensembl:ENSRNOP00000028829	P	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35454 ensembl:ENSMUSP00000028764	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35454 ensembl:ENSMUSP00000028764	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35454 ensembl:ENSMUSP00000028764	C	Seeded From UniProt	complete
enables	GO:0005185	neurohypophyseal hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000981 InterPro:IPR022423 InterPro:IPR036387	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000981 InterPro:IPR022423 InterPro:IPR036387	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10218979^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-749452 Reactome:R-HSA-749448 Reactome:R-HSA-388503 Reactome:R-HSA-379048	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kim, J et al. (2013) Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study. BMC Med. Genet. 14 77 PubMed GONUTS page
↑ Poutahidis, T et al. (2013) Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PLoS ONE 8 e78898 PubMed GONUTS page
↑ Kasahara, Y et al. (2007) Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure. Biosci. Biotechnol. Biochem. 71 3122-6 PubMed GONUTS page
↑ Copland, JA et al. (1999) Demonstration of functional oxytocin receptors in human breast Hs578T cells and their up-regulation through a protein kinase C-dependent pathway. Endocrinology 140 2258-67 PubMed GONUTS page

[PMID:23889750-1] Kim, J et al. (2013) Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study. BMC Med. Genet. 14 77 PubMed GONUTS page

[PMID:24205344-2] Poutahidis, T et al. (2013) Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PLoS ONE 8 e78898 PubMed GONUTS page

[PMID:18071238-3] Kasahara, Y et al. (2007) Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure. Biosci. Biotechnol. Biochem. 71 3122-6 PubMed GONUTS page

[PMID:10218979-4] Copland, JA et al. (1999) Demonstration of functional oxytocin receptors in human breast Hs578T cells and their up-regulation through a protein kinase C-dependent pathway. Endocrinology 140 2258-67 PubMed GONUTS page

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HUMAN:NEU1

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