PMID:24205344

Citation	Poutahidis, T, Kearney, SM, Levkovich, T, Qi, P, Varian, BJ, Lakritz, JR, Ibrahim, YM, Chatzigiagkos, A, Alm, EJ and Erdman, SE (2013) Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PLoS ONE 8:e78898
Abstract	Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. Impact of the microbiome upon the mammalian wound healing process is poorly understood. We discover that supplementing the gut microbiome with lactic acid microbes in drinking water accelerates the wound-healing process to occur in half the time required for matched control animals. Further, we find that Lactobacillus reuteri enhances wound-healing properties through up-regulation of the neuropeptide hormone oxytocin, a factor integral in social bonding and reproduction, by a vagus nerve-mediated pathway. Bacteria-triggered oxytocin serves to activate host CD4+Foxp3+CD25+ immune T regulatory cells conveying transplantable wound healing capacity to naive Rag2-deficient animals. This study determined oxytocin to be a novel component of a multi-directional gut microbe-brain-immune axis, with wound-healing capability as a previously unrecognized output of this axis. We also provide experimental evidence to support long-standing medical traditions associating diet, social practices, and the immune system with efficient recovery after injury, sustained good health, and longevity.
Links	PubMed PMC3813596 Online version:10.1371/journal.pone.0078898
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:NEU1		GO:0090303: positive regulation of wound healing	ECO:0000315:		P		Figure 6 & 7	complete CACAO 9538

References

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