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HUMAN:MUS81
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MUS81 | |
| Protein Name(s) | Crossover junction endonuclease MUS81 | |
| External Links | ||
| UniProt | Q96NY9 | |
| EMBL | AF425646 BC009999 AK024665 | |
| CCDS | CCDS8115.1 | |
| RefSeq | NP_079404.3 XP_011543572.1 | |
| UniGene | Hs.288798 | |
| PDB | 2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S | |
| PDBsum | 2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S | |
| ProteinModelPortal | Q96NY9 | |
| SMR | Q96NY9 | |
| BioGrid | 123170 | |
| DIP | DIP-48630N | |
| IntAct | Q96NY9 | |
| MINT | MINT-3056813 | |
| STRING | 9606.ENSP00000307853 | |
| PhosphoSite | Q96NY9 | |
| BioMuta | MUS81 | |
| DMDM | 166898077 | |
| MaxQB | Q96NY9 | |
| PaxDb | Q96NY9 | |
| PRIDE | Q96NY9 | |
| Ensembl | ENST00000308110 | |
| GeneID | 80198 | |
| KEGG | hsa:80198 | |
| UCSC | uc001ofv.4 | |
| CTD | 80198 | |
| GeneCards | GC11P065627 | |
| H-InvDB | HIX0009809 | |
| HGNC | HGNC:29814 | |
| HPA | HPA059530 | |
| MIM | 606591 | |
| neXtProt | NX_Q96NY9 | |
| PharmGKB | PA134881809 | |
| eggNOG | COG1948 | |
| GeneTree | ENSGT00390000005498 | |
| HOGENOM | HOG000113699 | |
| HOVERGEN | HBG052538 | |
| InParanoid | Q96NY9 | |
| KO | K08991 | |
| OMA | KCGRLQR | |
| OrthoDB | EOG7TXKGV | |
| PhylomeDB | Q96NY9 | |
| TreeFam | TF315113 | |
| ChiTaRS | MUS81 | |
| EvolutionaryTrace | Q96NY9 | |
| GeneWiki | MUS81 | |
| GenomeRNAi | 80198 | |
| NextBio | 70556 | |
| PRO | PR:Q96NY9 | |
| Proteomes | UP000005640 | |
| Bgee | Q96NY9 | |
| CleanEx | HS_MUS81 | |
| ExpressionAtlas | Q96NY9 | |
| Genevisible | Q96NY9 | |
| GO | GO:0005730 GO:0005634 GO:0048257 GO:0003677 GO:0046872 GO:0000737 GO:0006310 GO:0006281 GO:0072429 | |
| Gene3D | 1.10.8.310 3.40.50.10130 | |
| InterPro | IPR010996 IPR020819 IPR006166 IPR003583 IPR027420 IPR011335 | |
| Pfam | PF02732 | |
| SMART | SM00891 SM00278 | |
| SUPFAM | SSF47802 SSF52980 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0048257 |
3'-flap endonuclease activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0033687 |
osteoblast proliferation |
ECO:0000315 |
P |
Figure 4B,C |
complete | |||||
|
part_of |
GO:0048476 |
Holliday junction resolvase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000335543 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048257 |
3'-flap endonuclease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000335543 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031573 |
intra-S DNA damage checkpoint |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000335543 |
P |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0008821 |
crossover junction endodeoxyribonuclease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000335543 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000335543 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000727 |
double-strand break repair via break-induced replication |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000335543 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000712 |
resolution of meiotic recombination intermediates |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000335543 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072429 |
response to intra-S DNA damage checkpoint signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000737 |
DNA catabolic process, endonucleolytic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036297 |
interstrand cross-link repair |
Reactome:R-HSA-6783310 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6785986 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006310 |
DNA recombination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Muñoz, IM et al. (2009) Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol. Cell 35 116-27 PubMed GONUTS page
- ↑ Svendsen, JM et al. (2009) Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 138 63-77 PubMed GONUTS page
- ↑ Xing, M et al. (2015) Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget 6 37638-46 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Fugger, K et al. (2013) FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. Nat Commun 4 1423 PubMed GONUTS page
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