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HUMAN:MUL1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MUL1 (synonyms: C1orf166, GIDE, MAPL, MULAN, RNF218) | |
| Protein Name(s) | Mitochondrial ubiquitin ligase activator of NFKB 1
E3 SUMO-protein ligase MUL1 E3 ubiquitin-protein ligase MUL1 Growth inhibition and death E3 ligase Mitochondrial-anchored protein ligase MAPL Putative NF-kappa-B-activating protein 266 RING finger protein 218 RING-type E3 ubiquitin transferase NFKB 1 (ECO:0000305) | |
| External Links | ||
| UniProt | Q969V5 | |
| EMBL | EU935008 AB097015 AK022937 AL833889 AL391357 BC010101 BC014010 | |
| CCDS | CCDS208.1 | |
| RefSeq | NP_078820.2 | |
| UniGene | Hs.10101 | |
| ProteinModelPortal | Q969V5 | |
| SMR | Q969V5 | |
| BioGrid | 122734 | |
| IntAct | Q969V5 | |
| MINT | MINT-1464078 | |
| STRING | 9606.ENSP00000264198 | |
| iPTMnet | Q969V5 | |
| PhosphoSitePlus | Q969V5 | |
| BioMuta | MUL1 | |
| DMDM | 74760689 | |
| EPD | Q969V5 | |
| MaxQB | Q969V5 | |
| PaxDb | Q969V5 | |
| PeptideAtlas | Q969V5 | |
| PRIDE | Q969V5 | |
| DNASU | 79594 | |
| Ensembl | ENST00000264198 | |
| GeneID | 79594 | |
| KEGG | hsa:79594 | |
| UCSC | uc001bdi.5 | |
| CTD | 79594 | |
| DisGeNET | 79594 | |
| EuPathDB | HostDB:ENSG00000090432.6 | |
| GeneCards | MUL1 | |
| HGNC | HGNC:25762 | |
| HPA | HPA026827 | |
| MIM | 612037 | |
| neXtProt | NX_Q969V5 | |
| OpenTargets | ENSG00000090432 | |
| PharmGKB | PA162396329 | |
| eggNOG | KOG1571 ENOG410YF4M | |
| GeneTree | ENSGT00390000012141 | |
| HOGENOM | HOG000007562 | |
| HOVERGEN | HBG106376 | |
| InParanoid | Q969V5 | |
| KO | K15688 | |
| OMA | VCSCAEC | |
| OrthoDB | EOG091G0OPO | |
| PhylomeDB | Q969V5 | |
| TreeFam | TF325195 | |
| BRENDA | 6.3.2.19 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-5689880 R-HSA-5689880] | |
| SIGNOR | Q969V5 | |
| UniPathway | UPA00143 UPA00886 | |
| GenomeRNAi | 79594 | |
| PRO | PR:Q969V5 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000090432 | |
| CleanEx | HS_MUL1 | |
| ExpressionAtlas | Q969V5 | |
| Genevisible | Q969V5 | |
| GO | GO:0030424 GO:0031307 GO:0016020 GO:0005739 GO:0043025 GO:0005777 GO:0042802 GO:0046872 GO:0004871 GO:0019789 GO:0031625 GO:0004842 GO:0006919 GO:0007257 GO:0006915 GO:0071360 GO:0000266 GO:0051646 GO:0030308 GO:0071650 GO:0050689 GO:0045824 GO:0010637 GO:0051898 GO:0060339 GO:1904925 GO:1903861 GO:0043123 GO:0090141 GO:0033235 GO:0031648 GO:0050821 GO:0016567 GO:0051881 GO:1901028 GO:0010821 | |
| InterPro | IPR022170 IPR001841 | |
| Pfam | PF12483 | |
| PROSITE | PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010821 |
regulation of mitochondrion organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031648 |
protein destabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q8IWA4)|has_regulation_target:(UniProtKB:O95140) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901028 |
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090141 |
positive regulation of mitochondrial fission |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071650 |
negative regulation of chemokine (C-C motif) ligand 5 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071360 |
cellular response to exogenous dsRNA |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060339 |
negative regulation of type I interferon-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051898 |
negative regulation of protein kinase B signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051646 |
mitochondrion localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:O00429) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050689 |
negative regulation of defense response to virus by host |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045824 |
negative regulation of innate immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0007001 |
high throughput mutant phenotypic evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033235 |
positive regulation of protein sumoylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P63165)|has_direct_input(UniProtKB:P63279) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031625 |
ubiquitin protein ligase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031307 |
integral component of mitochondrial outer membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031307 |
integral component of mitochondrial outer membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030308 |
negative regulation of cell growth |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019789 |
SUMO transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010637 |
negative regulation of mitochondrial fusion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007257 |
activation of JUN kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005777 |
peroxisome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000266 |
mitochondrial fission |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904925 |
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VCM5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903861 |
positive regulation of dendrite extension |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VCM5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VCM5 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031647 |
regulation of protein stability |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8VCM5 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006996 |
organelle organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005777 |
peroxisome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016925 |
protein sumoylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00886 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Yun, J et al. (2014) MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife 3 e01958 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Zhang, B et al. (2008) GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. Cell Res. 18 900-10 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Braschi, E et al. (2009) MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep. 10 748-54 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Jenkins, K et al. (2013) Mitochondrially localised MUL1 is a novel modulator of antiviral signaling. Immunol. Cell Biol. 91 321-30 PubMed GONUTS page
- ↑ Bae, S et al. (2012) Akt is negatively regulated by the MULAN E3 ligase. Cell Res. 22 873-85 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Li, W et al. (2008) Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS ONE 3 e1487 PubMed GONUTS page
- ↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Neuspiel, M et al. (2008) Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. Curr. Biol. 18 102-8 PubMed GONUTS page
m
n
- GO:0050689 ! negative regulation of defense response to virus by host
- GO:0030308 ! negative regulation of cell growth
- GO:0051898 ! negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0060339 ! negative regulation of type I interferon-mediated signaling pathway
- GO:0010637 ! negative regulation of mitochondrial fusion
- GO:0071650 ! negative regulation of chemokine (C-C motif) ligand 5 production
- GO:0045824 ! negative regulation of innate immune response
- GO:0043025 ! neuronal cell body
o
- GO:0006919 ! obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0007257 ! obsolete activation of JUN kinase activity
- GO:0031307 ! obsolete integral component of mitochondrial outer membrane
- GO:1904925 ! obsolete positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
- GO:0006996 ! organelle organization
p
- GO:0005777 ! peroxisome
- GO:1903861 ! positive regulation of dendrite extension
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:0033235 ! positive regulation of protein sumoylation
- GO:0090141 ! positive regulation of mitochondrial fission
- Primates
- GO:0031648 ! protein destabilization
- GO:0050821 ! protein stabilization
- GO:0016925 ! protein sumoylation
- GO:0016567 ! protein ubiquitination
r
