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HUMAN:MSH4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MSH4
Protein Name(s) MutS protein homolog 4

hMSH4

External Links
UniProt O15457
EMBL U89293
AF104243
AY268350
AL357314
AL445464
AL445464
AL357314
CH471059
BC033030
CCDS CCDS670.1
RefSeq NP_002431.2
UniGene Hs.216639
ProteinModelPortal O15457
SMR O15457
BioGrid 110575
IntAct O15457
MINT MINT-7002259
STRING 9606.ENSP00000263187
PhosphoSite O15457
PaxDb O15457
PRIDE O15457
DNASU 4438
Ensembl ENST00000263187
GeneID 4438
KEGG hsa:4438
UCSC uc001dhd.2
CTD 4438
GeneCards GC01P076262
HGNC HGNC:7327
HPA HPA028117
MIM 602105
neXtProt NX_O15457
PharmGKB PA31135
eggNOG COG0249
GeneTree ENSGT00550000074897
HOGENOM HOG000290656
HOVERGEN HBG036910
InParanoid O15457
KO K08740
OMA WTPQMGY
OrthoDB EOG7DRJ2N
PhylomeDB O15457
TreeFam TF300572
Reactome REACT_27271
ChiTaRS MSH4
GeneWiki MSH4
GenomeRNAi 4438
NextBio 17297
PRO PR:O15457
Proteomes UP000005640
Bgee O15457
CleanEx HS_MSH4
ExpressionAtlas O15457
Genevestigator O15457
GO GO:0005634
GO:0000795
GO:0005524
GO:0003677
GO:0008094
GO:0030983
GO:0006200
GO:0051026
GO:0007292
GO:0045143
GO:0006298
GO:0001541
GO:0007131
GO:0007283
Gene3D 3.30.420.110
3.40.50.300
InterPro IPR000432
IPR007861
IPR007696
IPR007860
IPR027417
Pfam PF05188
PF05192
PF05190
PF00488
SMART SM00534
SM00533
SUPFAM SSF48334
SSF52540
PROSITE PS00486

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051026

chiasma assembly

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145706
WB:WBGene00001872

P

Seeded From UniProt

complete

involved_in

GO:0045143

homologous chromosome segregation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145706
WB:WBGene00001872

P

Seeded From UniProt

complete

part_of

GO:0032300

mismatch repair complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779

C

Seeded From UniProt

complete

contributes_to

GO:0032143

single thymine insertion binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260779
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

contributes_to

GO:0032137

guanine/thymine mispair binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
MGI:MGI:1343961
PANTHER:PTN002260779
SGD:S000001162
SGD:S000002504
SGD:S000005450
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

enables

GO:0008094

DNA-dependent ATPase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260779
SGD:S000001162

F

Seeded From UniProt

complete

involved_in

GO:0007292

female gamete generation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1860077
PANTHER:PTN000145716

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1860077
PANTHER:PTN002603902

P

Seeded From UniProt

complete

involved_in

GO:0007131

reciprocal meiotic recombination

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145706
SGD:S000001891
WB:WBGene00001872

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
FB:FBgn0015546
MGI:MGI:101816
MGI:MGI:109519
MGI:MGI:1343961
PANTHER:PTN000145505
PomBase:SPBC19G7.01c
PomBase:SPCC285.16c
SGD:S000000688
SGD:S000001162
SGD:S000002504
SGD:S000005450
TAIR:locus:2095097
UniProtKB:P20585
UniProtKB:P43246
UniProtKB:P52701
WB:WBGene00003418
WB:WBGene00003422

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450

F

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
MGI:MGI:109519
MGI:MGI:1343961
PANTHER:PTN002260779
TAIR:locus:2095097
TAIR:locus:2131829
UniProtKB:O04716

F

Seeded From UniProt

complete

involved_in

GO:0001541

ovarian follicle development

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1860077
PANTHER:PTN000145716

P

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1860077
PANTHER:PTN000145706

C

Seeded From UniProt

complete

involved_in

GO:0000712

resolution of meiotic recombination intermediates

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145706
WB:WBGene00001872

P

Seeded From UniProt

complete

part_of

GO:0000228

nuclear chromosome

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145706
SGD:S000001891

C

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

P

Seeded From UniProt

complete

involved_in

GO:0007292

female gamete generation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

P

Seeded From UniProt

complete

involved_in

GO:0007129

synapsis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

P

Seeded From UniProt

complete

part_of

GO:0005713

recombination nodule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

C

Seeded From UniProt

complete

involved_in

GO:0001541

ovarian follicle development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

P

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

C

Seeded From UniProt

complete

part_of

GO:0000794

condensed nuclear chromosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

C

Seeded From UniProt

complete

part_of

GO:0000793

condensed chromosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99MT2
ensembl:ENSMUSP00000005630

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR036678

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR017261
InterPro:IPR036678

P

Seeded From UniProt

complete

enables

GO:0030983

mismatched DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR017261
InterPro:IPR036678

F

Seeded From UniProt

complete

involved_in

GO:0007131

reciprocal meiotic recombination

PMID:9299235[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9299235[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:9299235[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Paquis-Flucklinger, V et al. (1997) Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene. Genomics 44 188-94 PubMed GONUTS page
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