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HUMAN:MRP4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ABCC4 (synonyms: MRP4)
Protein Name(s) Multidrug resistance-associated protein 4

ATP-binding cassette sub-family C member 4 MRP/cMOAT-related ABC transporter Multi-specific organic anion transporter B MOAT-B

External Links
UniProt O15439
EMBL AF071202
AY081219
AY207008
AF541977
AL157818
AL139381
AL356257
AL139381
AL157818
AL356257
AL356257
AL139381
AL157818
AL359750
CH471085
CH471085
BC041560
U83660
CCDS CCDS9474.1
RefSeq NP_001098985.1
NP_001288758.1
NP_005836.2
UniGene Hs.508423
ProteinModelPortal O15439
SMR O15439
BioGrid 115551
IntAct O15439
STRING 9606.ENSP00000366084
BindingDB O15439
ChEMBL CHEMBL1743128
DrugBank DB00718
DB00770
DB01076
DB01327
DB00482
DB00286
DB00586
DB00917
DB00975
DB00544
DB00712
DB00158
DB08884
DB00143
DB01050
DB00328
DB01009
DB00709
DB00650
DB00814
DB01033
DB00563
DB00731
DB00198
DB01032
DB01098
DB00203
DB00398
DB01138
DB01268
DB00300
DB00352
DB01586
DB00661
DB00495
TCDB 3.A.1.208.7
PhosphoSite O15439
MaxQB O15439
PaxDb O15439
PRIDE O15439
Ensembl ENST00000376887
GeneID 10257
KEGG hsa:10257
UCSC uc001vmd.4
uc001vme.2
uc010afk.3
CTD 10257
GeneCards GC13M095672
HGNC HGNC:55
HPA CAB002751
HPA002476
MIM 605250
neXtProt NX_O15439
PharmGKB PA397
eggNOG COG1132
GeneTree ENSGT00770000120479
HOVERGEN HBG108314
InParanoid O15439
KO K05673
OMA FQLCICQ
OrthoDB EOG7MWGW0
PhylomeDB O15439
TreeFam TF105202
Reactome REACT_15480
ChiTaRS ABCC4
GeneWiki ABCC4
GenomeRNAi 10257
NextBio 38868
PRO PR:O15439
Proteomes UP000005640
Bgee O15439
CleanEx HS_ABCC4
ExpressionAtlas O15439
Genevestigator O15439
GO GO:0016323
GO:0016021
GO:0016020
GO:0005886
GO:0031088
GO:0016404
GO:0005524
GO:0042626
GO:0007596
GO:0055114
GO:0030168
GO:0002576
GO:0048661
GO:0042493
GO:0014070
GO:0010243
GO:0055085
Gene3D 3.40.50.300
InterPro IPR003593
IPR011527
IPR003439
IPR017871
IPR030240
IPR027417
PANTHER PTHR24223:SF205
Pfam PF00664
PF00005
SMART SM00382
SUPFAM SSF52540
SSF90123
PROSITE PS50929
PS00211
PS50893

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016323

basolateral plasma membrane

PMID:24130369[1]

ECO:0000314

C

Figure 2D

complete
CACAO 9063

part_of

GO:0016323

basolateral plasma membrane

PMID:24130369[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016404

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

PMID:7557451[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000657997
RGD:3112
SGD:S000002542
TAIR:locus:2061559
UniProtKB:A7KVC2
UniProtKB:Q10RX7

P

Seeded From UniProt

complete

enables

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000657997
RGD:71101
TAIR:locus:2061559
UniProtKB:Q9LK64

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1352447
PANTHER:PTN000657997
RGD:2366
RGD:3112
RGD:620268
UniProtKB:O15439
UniProtKB:O15440

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2443111
MGI:MGI:88388
PANTHER:PTN002384279
UniProtKB:O15439
UniProtKB:P13569

C

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:25173977[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032310

prostaglandin secretion

PMID:25173977[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031088

platelet dense granule membrane

PMID:15297306[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:15297306[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:25173977[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15297306[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016404

P

Seeded From UniProt

complete

involved_in

GO:0099131

ATP hydrolysis coupled ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015662

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9Q236
ensembl:ENSMUSP00000042186

C

Seeded From UniProt

complete

involved_in

GO:0048661

positive regulation of smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M3J4
ensembl:ENSRNOP00000033826

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M3J4
ensembl:ENSRNOP00000033826

P

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M3J4
ensembl:ENSRNOP00000033826

C

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M3J4
ensembl:ENSRNOP00000033826

P

Seeded From UniProt

complete

involved_in

GO:0010243

response to organonitrogen compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M3J4
ensembl:ENSRNOP00000033826

P

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M3J4
ensembl:ENSRNOP00000033826

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003439
InterPro:IPR011527
InterPro:IPR017871
InterPro:IPR030240
InterPro:IPR036640

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011527
InterPro:IPR030240
InterPro:IPR036640

C

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003439
InterPro:IPR017871

F

Seeded From UniProt

complete

enables

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011527
InterPro:IPR030240

F

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011527
InterPro:IPR030240

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

Reactome:R-HSA-382556

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031088

platelet dense granule membrane

Reactome:R-HSA-429157

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0015662

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

Reactome:R-HSA-429157

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-1454916

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002576

platelet degranulation

Reactome:R-HSA-114608

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Klein, DM et al. (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis. Drug Metab. Dispos. 42 89-93 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ Pichaud, F et al. (1995) Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Gene 162 319-22 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Jin, D et al. (2014) Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nat. Cell Biol. 16 841-51 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Jedlitschky, G et al. (2004) The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood 104 3603-10 PubMed GONUTS page
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