HUMAN:MP2K1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAP2K1 (synonyms: MEK1, PRKMK1)
Protein Name(s)	Dual specificity mitogen-activated protein kinase kinase 1 MAP kinase kinase 1 MAPKK 1 MKK1 ERK activator kinase 1 MAPK/ERK kinase 1 MEK 1
External Links
UniProt	Q02750
EMBL	L05624 L11284
CCDS	CCDS10216.1
PIR	A45100
RefSeq	NP_002746.1 XP_006720671.1
UniGene	Hs.145442
PDB	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81
PDBsum	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81
ProteinModelPortal	Q02750
SMR	Q02750
BioGrid	111590
DIP	DIP-201N
IntAct	Q02750
MINT	MINT-99632
STRING	9606.ENSP00000302486
BindingDB	Q02750
ChEMBL	CHEMBL2111351
DrugBank	DB06616 DB08911
GuidetoPHARMACOLOGY	2062
PhosphoSite	Q02750
DMDM	400274
MaxQB	Q02750
PaxDb	Q02750
PeptideAtlas	Q02750
PRIDE	Q02750
DNASU	5604
Ensembl	ENST00000307102
GeneID	5604
KEGG	hsa:5604
UCSC	uc010bhq.3
CTD	5604
GeneCards	GC15P066679
GeneReviews	MAP2K1
HGNC	HGNC:6840
HPA	CAB003834 HPA026430
MIM	176872 615279
neXtProt	NX_Q02750
Orphanet	1340
PharmGKB	PA30584
eggNOG	COG0515
GeneTree	ENSGT00760000119199
HOGENOM	HOG000234206
HOVERGEN	HBG108518
InParanoid	Q02750
KO	K04368
OMA	RDKHAIM
OrthoDB	EOG7HF1KZ
PhylomeDB	Q02750
TreeFam	TF105137
BRENDA	2.7.12.2
Reactome	REACT_1391 REACT_22272 REACT_22442 REACT_228255 REACT_614 REACT_9470 REACT_962
SignaLink	Q02750
ChiTaRS	MAP2K1
EvolutionaryTrace	Q02750
GeneWiki	MAP2K1
GenomeRNAi	5604
NextBio	21776
PMAP-CutDB	Q02750
PRO	PR:Q02750
Proteomes	UP000005640
Bgee	Q02750
CleanEx	HS_MAP2K1
ExpressionAtlas	Q02750
Genevestigator	Q02750
GO	GO:0030424 GO:0005938 GO:0005737 GO:0005829 GO:0032839 GO:0005769 GO:0070062 GO:0005925 GO:0005794 GO:0005770 GO:0005874 GO:0005815 GO:0005739 GO:0005634 GO:0043204 GO:0048471 GO:0005886 GO:0005524 GO:0004708 GO:0004672 GO:0043539 GO:0004674 GO:0004712 GO:0004713 GO:0004728 GO:0000187 GO:0000186 GO:0007411 GO:0007050 GO:0048870 GO:0008283 GO:0006928 GO:0090398 GO:0006935 GO:0007173 GO:0038095 GO:0008543 GO:0048313 GO:0045087 GO:0008286 GO:0030216 GO:0060711 GO:0000165 GO:0032402 GO:0007067 GO:0002755 GO:0002756 GO:0008285 GO:0034111 GO:0048011 GO:0060674 GO:0045597 GO:0030335 GO:0010628 GO:0071902 GO:0032320 GO:0046579 GO:0032968 GO:0051291 GO:0007265 GO:2000641 GO:0090170 GO:0032872 GO:0003056 GO:0048678 GO:0051384 GO:0006979 GO:0007165 GO:0007264 GO:0051403 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666 GO:0047496
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0097110	scaffold protein binding	PMID:10409742^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61097	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:26514923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:18305109^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:P46527)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18305109^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:P46527)	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:18305109^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:24375836^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	PMID:24375836^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(RNAcentral:URS00003768C5_9606)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24375836^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000170345) part_of:(GO:0070371)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23626836^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P36507	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:10644344^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P28482)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15155804^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q9BX97)	Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	PMID:9765203^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:9765203^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:9765203^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:8388392^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	PMID:8388392^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P27361)	Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	PMID:8388392^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346866 PANTHER:PTN000684587 RGD:70495	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261524 MGI:MGI:1346866 MGI:MGI:1346868 PANTHER:PTN000684494 PomBase:SPAC1D4.13 PomBase:SPBC409.07c RGD:1307040 RGD:1560043 RGD:61888 RGD:620666 RGD:70495 SGD:S000002318 SGD:S000003664 TAIR:locus:2017662 TAIR:locus:2120855 TAIR:locus:2164981 TAIR:locus:2170578 TAIR:locus:2206885 UniProtKB:A0A1D8PKE2 UniProtKB:O14733 UniProtKB:P36507 UniProtKB:P52564 UniProtKB:Q02750 UniProtKB:Q5BEU9 UniProtKB:Q9S7U9 WB:WBGene00003185 WB:WBGene00003186 WB:WBGene00004758 dictyBase:DDB_G0269152	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261524 MGI:MGI:1346866 MGI:MGI:1346868 MGI:MGI:1346870 PANTHER:PTN000684494 RGD:61890 RGD:70495 SGD:S000002318 SGD:S000003664 UniProtKB:P52564 UniProtKB:Q02750 WB:WBGene00003185 WB:WBGene00003368 WB:WBGene00004758 dictyBase:DDB_G0269152	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:22572157^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:22572157^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:22572157^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:28166211^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	PMID:28166211^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0060711	labyrinthine layer development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0060674	placenta blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0060440	trachea formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0060324	face development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0060020	Bergmann glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0050772	positive regulation of axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0048870	cell motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0048679	regulation of axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0021697	cerebellar cortex formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31938 ensembl:ENSMUSP00000005066	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10570282^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:10570282^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10570282^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000641	regulation of early endosome to late endosome transport	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090170	regulation of Golgi inheritance	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032872	regulation of stress-activated MAPK cascade	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19565474^[14] Reactome:R-HSA-6803234 Reactome:R-HSA-6803233 Reactome:R-HSA-6803230 Reactome:R-HSA-6803227 Reactome:R-HSA-6802943 Reactome:R-HSA-6802942 Reactome:R-HSA-6802935 Reactome:R-HSA-6802934 Reactome:R-HSA-6802933 Reactome:R-HSA-6802932 Reactome:R-HSA-6802926 Reactome:R-HSA-6802925 Reactome:R-HSA-6802922 Reactome:R-HSA-6802921 Reactome:R-HSA-6802919 Reactome:R-HSA-6802918 Reactome:R-HSA-6802914 Reactome:R-HSA-6802912 Reactome:R-HSA-6802911 Reactome:R-HSA-6802910 Reactome:R-HSA-5674496 Reactome:R-HSA-5674373 Reactome:R-HSA-5674366 Reactome:R-HSA-5674132 Reactome:R-HSA-5674130 Reactome:R-HSA-5672980 Reactome:R-HSA-5672978 Reactome:R-HSA-5672973 Reactome:R-HSA-5672972 Reactome:R-HSA-5211340 Reactome:R-HSA-112342 Reactome:R-HSA-109863 Reactome:R-HSA-109860 Reactome:R-HSA-109857	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:19565474^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:19565474^[14] Reactome:R-HSA-112409	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-109860	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Stewart, S et al. (1999) Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol. Cell. Biol. 19 5523-34 PubMed GONUTS page
↑ Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wang, C et al. (2008) A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. J. Biol. Chem. 283 11565-74 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Lv, XB et al. (2014) MiR-92a mediates AZD6244 induced apoptosis and G1-phase arrest of lymphoma cells by targeting Bim. Cell Biol. Int. 38 435-43 PubMed GONUTS page
↑ D'Agnillo, F et al. (2013) Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions. PLoS ONE 8 e62576 PubMed GONUTS page
↑ Aoki, H et al. (2000) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. J. Virol. 74 1736-41 PubMed GONUTS page
↑ Stan, RV et al. (2004) PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms. Mol. Biol. Cell 15 3615-30 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Lin, AW et al. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12 3008-19 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Zheng, CF & Guan, KL (1993) Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268 11435-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Quiel, A et al. () Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron 36 207-11 PubMed GONUTS page
↑ ^12.0 ^12.1 Goyal, Y et al. (2017) Divergent effects of intrinsically active MEK variants on developmental Ras signaling. Nat. Genet. 49 465-469 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Sotsios, Y et al. (1999) The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J. Immunol. 163 5954-63 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page

[PMID:10409742-1] Stewart, S et al. (1999) Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol. Cell. Biol. 19 5523-34 PubMed GONUTS page

[PMID:26514923-2] Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page

[PMID:18305109-3] 3.0 ^3.1 ^3.2 Wang, C et al. (2008) A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. J. Biol. Chem. 283 11565-74 PubMed GONUTS page

[PMID:24375836-4] 4.0 ^4.1 ^4.2 Lv, XB et al. (2014) MiR-92a mediates AZD6244 induced apoptosis and G1-phase arrest of lymphoma cells by targeting Bim. Cell Biol. Int. 38 435-43 PubMed GONUTS page

[PMID:23626836-5] D'Agnillo, F et al. (2013) Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions. PLoS ONE 8 e62576 PubMed GONUTS page

[PMID:10644344-6] Aoki, H et al. (2000) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. J. Virol. 74 1736-41 PubMed GONUTS page

[PMID:15155804-7] Stan, RV et al. (2004) PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms. Mol. Biol. Cell 15 3615-30 PubMed GONUTS page

[PMID:9765203-8] 8.0 ^8.1 ^8.2 Lin, AW et al. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12 3008-19 PubMed GONUTS page

[PMID:8388392-9] 9.0 ^9.1 ^9.2 Zheng, CF & Guan, KL (1993) Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268 11435-9 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22572157-11] 11.0 ^11.1 ^11.2 Quiel, A et al. () Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron 36 207-11 PubMed GONUTS page

[PMID:28166211-12] 12.0 ^12.1 Goyal, Y et al. (2017) Divergent effects of intrinsically active MEK variants on developmental Ras signaling. Nat. Genet. 49 465-469 PubMed GONUTS page

[PMID:10570282-13] 13.0 ^13.1 ^13.2 Sotsios, Y et al. (1999) The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J. Immunol. 163 5954-63 PubMed GONUTS page

[PMID:19565474-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page

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