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HUMAN:MMP9
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | MMP9 (synonyms: CLG4B) | |
Protein Name(s) | Matrix metalloproteinase-9
MMP-9 92 kDa gelatinase 92 kDa type IV collagenase Gelatinase B GELB 67 kDa matrix metalloproteinase-9 82 kDa matrix metalloproteinase-9 | |
External Links | ||
UniProt | P14780 | |
EMBL | J05070 M68343 M68344 M68345 M68346 M68347 M68348 M68349 M68350 M68351 M68352 M68353 M68354 M68355 AK313137 AF538844 DQ194553 AL162458 BC006093 D10051 | |
CCDS | CCDS13390.1 | |
PIR | A34458 | |
RefSeq | NP_004985.2 | |
UniGene | Hs.297413 | |
PDB | 1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG | |
PDBsum | 1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG | |
ProteinModelPortal | P14780 | |
SMR | P14780 | |
BioGrid | 110461 | |
DIP | DIP-29518N | |
IntAct | P14780 | |
MINT | MINT-7709677 | |
STRING | 9606.ENSP00000361405 | |
BindingDB | P14780 | |
ChEMBL | CHEMBL2095216 | |
DrugBank | DB01197 DB01296 DB00786 DB01017 | |
GuidetoPHARMACOLOGY | 1633 | |
MEROPS | M10.004 | |
PhosphoSite | P14780 | |
UniCarbKB | P14780 | |
DMDM | 269849668 | |
PaxDb | P14780 | |
PeptideAtlas | P14780 | |
PRIDE | P14780 | |
DNASU | 4318 | |
Ensembl | ENST00000372330 | |
GeneID | 4318 | |
KEGG | hsa:4318 | |
UCSC | uc002xqz.3 | |
CTD | 4318 | |
GeneCards | GC20P044637 | |
H-InvDB | HIX0015874 | |
HGNC | HGNC:7176 | |
HPA | CAB000348 HPA001238 | |
MIM | 120361 603932 613073 | |
neXtProt | NX_P14780 | |
Orphanet | 1040 | |
PharmGKB | PA30889 | |
eggNOG | NOG328372 | |
GeneTree | ENSGT00760000119132 | |
HOVERGEN | HBG052484 | |
InParanoid | P14780 | |
KO | K01403 | |
OMA | EGDLKWH | |
OrthoDB | EOG70KGNX | |
PhylomeDB | P14780 | |
TreeFam | TF315428 | |
Reactome | REACT_111040 REACT_118572 REACT_118682 REACT_150180 REACT_150401 REACT_228189 | |
ChiTaRS | MMP9 | |
EvolutionaryTrace | P14780 | |
GeneWiki | MMP9 | |
GenomeRNAi | 4318 | |
NextBio | 16989 | |
PRO | PR:P14780 | |
Proteomes | UP000005640 | |
Bgee | P14780 | |
CleanEx | HS_MMP9 | |
Genevestigator | P14780 | |
GO | GO:0005576 GO:0005615 GO:0070062 GO:0005578 GO:0005518 GO:0004175 GO:0042802 GO:0004222 GO:0008270 GO:0030574 GO:0007566 GO:0035987 GO:0022617 GO:0030198 GO:0050900 GO:0030225 GO:2001258 GO:0001503 GO:0043065 GO:0051549 GO:1900122 GO:0006508 GO:0001501 | |
Gene3D | 2.10.10.10 2.110.10.10 3.40.390.10 | |
InterPro | IPR000562 IPR000585 IPR018487 IPR018486 IPR013806 IPR024079 IPR028688 IPR001818 IPR021190 IPR021158 IPR006026 IPR002477 IPR006970 | |
PANTHER | PTHR10201:SF30 | |
Pfam | PF00040 PF00045 PF00413 PF01471 PF04886 | |
PRINTS | PR00138 | |
SMART | SM00059 SM00120 SM00235 | |
SUPFAM | SSF47090 SSF50923 SSF57440 | |
PROSITE | PS00546 PS00023 PS51092 PS00024 PS51642 PS00142 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0045742 |
positive regulation of epidermal growth factor receptor signaling pathway |
ECO:0000315 |
P |
Figure 4A shows that silencing uPAR and MMP-9 significantly inhibits the phosphorylation of the EGFR pathway. |
complete | |||||
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000315 |
P |
Figure 4B shows, through pUM transfection, that silencing uPAR and MMP-9 significantly lowers the amount of phosphorylated STAT protein in the nucleus. |
complete | |||||
GO:0043388 |
positive regulation of DNA binding |
ECO:0000314 |
P |
Figure 4C shows (through EMSA) that downregulation of uPAR and MMP-9 significantly inhibits binding activity of nuclear extract to STAT3 DNA probe. |
complete | |||||
GO:0008633 |
activation of pro-apoptotic gene products |
ECO:0000315 |
P |
Figure 2 |
complete | |||||
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000315 |
P |
Figure 4B shows, through pUM transfection, that silencing uPAR and MMP-9 significantly lowers the amount of phosphorylated STAT protein in the nucleus. |
complete | |||||
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
P |
Figure 1C and 1D show, through the Apo BrdU Assay and the Annexin-V assay, that inhibition of uPAR and MMP-9 induce apoptosis in Daoy and D283 cells. |
complete | |||||
GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway |
ECO:0000315 |
P |
Figure 2 shows that downregulation of uPAR and MMP9 increases levels of gene products that induce apoptosis, showing that normal function negatively regulates apoptotic signaling pathways. |
complete | |||||
GO:0090200 |
positive regulation of release of cytochrome c from mitochondria |
ECO:0000315 |
P |
Fig. 2 shows that downregulation of uPAR and MMP9 in Medulloblastoma cells causes a decrease in the amount of cytosolic cytochrome c, indicating a positive regulation of release of cytochrome c from mitochondria. |
complete | |||||
GO:2001268 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
ECO:0000315 |
P |
Fig. 3 showed that down regulation of uPAR and MMP9 in Daoy and D283 cells activates caspase activity. |
complete | |||||
GO:0008237 |
metalloendopeptidase activity |
ECO:0000315 |
F |
Figure 4a-c MMP-9 induces cleavage of CD44 into the extracellular domain and the intracellular domain in 4910 and 5310 xenograft cells. The interaction of MMP-9 with CD44 induced CD44 cleavage which was inhibited by both transcriptional knockdown of MMP-9 and with MMP-9 specific inhibitor. Further, supplementation of purified and activated human MMP-9 (hMMP-9) in MMP-9-knockdown cells resumed CD44 cleavage and migration. Additionally, activated hMMP-9 protein induced cleavage of recombinant human CD44. |
complete | |||||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002371) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904645 |
response to amyloid-beta |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
occurs_in:(CL:0000129) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
RNAcentral:URS000029D9F1_9606 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000697 |
negative regulation of epithelial cell differentiation involved in kidney development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
occurs_in:(CL:0002570) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034614 |
cellular response to reactive oxygen species |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071276 |
cellular response to cadmium ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007318) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0002012) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007311) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000235) |
Seeded From UniProt |
complete | ||
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001268 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090200 |
positive regulation of release of cytochrome c from mitochondria |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043388 |
positive regulation of DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045742 |
positive regulation of epidermal growth factor receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:P37840) |
Seeded From UniProt |
complete | ||
enables |
GO:0004175 |
endopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P37840) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035987 |
endodermal cell differentiation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001258 |
negative regulation of cation channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1900122 |
positive regulation of receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:Q16281) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_input:(UniProtKB:Q16281)|has_input:(UniProtKB:P29973) |
Seeded From UniProt |
complete | ||
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_input:(UniProtKB:Q16281)|has_input:(UniProtKB:P29973) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051549 |
positive regulation of keratinocyte migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101900 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97005 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000697 |
negative regulation of epithelial cell differentiation involved in kidney development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904645 |
response to amyloid-beta |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008233 |
peptidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007566 |
embryo implantation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001501 |
skeletal system development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41245 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001503 |
ossification |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050900 |
leukocyte migration |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0150077 |
regulation of neuroinflammatory response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030225 |
macrophage differentiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008270 |
zinc ion binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005518 |
collagen binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:1904813 |
ficolin-1-rich granule lumen |
Reactome:R-HSA-6800434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:1904724 |
tertiary granule lumen |
Reactome:R-HSA-6798745 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048013 |
ephrin receptor signaling pathway |
Reactome:R-HSA-2682334 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030574 |
collagen catabolic process |
Reactome:R-HSA-1442490 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0022617 |
extracellular matrix disassembly |
Reactome:R-HSA-1474228 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6785807 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
Reactome:R-NUL-3814821 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0004222 |
metalloendopeptidase activity |
Reactome:R-NUL-2484927 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Kotipatruni, RR et al. (2012) Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma. PLoS ONE 7 e44798 PubMed GONUTS page
- ↑ Chetty, C et al. (2012) MMP-9 induces CD44 cleavage and CD44 mediated cell migration in glioblastoma xenograft cells. Cell. Signal. 24 549-59 PubMed GONUTS page
- ↑ Glavey, SV et al. (2017) Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia 31 2426-2434 PubMed GONUTS page
- ↑ Luan, W et al. (2017) miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma. Onco Targets Ther 10 1237-1246 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
- ↑ El-Bizri, N et al. (2008) SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development 135 2981-91 PubMed GONUTS page
- ↑ Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page
- ↑ 9.0 9.1 De Clercq, S et al. (2013) L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages. PLoS ONE 8 e78108 PubMed GONUTS page
- ↑ Sung, JY et al. (2005) Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J. Biol. Chem. 280 25216-24 PubMed GONUTS page
- ↑ 11.0 11.1 Levin, J et al. (2009) Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases. Exp. Neurol. 215 201-8 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Brafman, DA et al. (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 20 369-81 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 Meighan, SE et al. (2013) Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating. Biochemistry 52 8352-62 PubMed GONUTS page
- ↑ Zigrino, P et al. (2007) Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration. J. Biol. Chem. 282 30785-93 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 16.5 Wilhelm, SM et al. (1989) SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J. Biol. Chem. 264 17213-21 PubMed GONUTS page
- ↑ Stenman, M et al. (2005) Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. Am. J. Pathol. 167 1119-24 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 18.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Litterst, C et al. (2007) Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J. Biol. Chem. 282 16155-63 PubMed GONUTS page
- ↑ Takahashi, C et al. (1998) Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc. Natl. Acad. Sci. U.S.A. 95 13221-6 PubMed GONUTS page
- ↑ Malla, N et al. (2013) In vitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican. FEBS J. 280 2870-87 PubMed GONUTS page
- ↑ Ardi, VC et al. (2007) Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 104 20262-7 PubMed GONUTS page
- ↑ Rosenblum, G et al. (2007) Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B. Structure 15 1227-36 PubMed GONUTS page
- ↑ Lee, EJ et al. (2014) Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation. J. Immunol. 193 2384-93 PubMed GONUTS page
- ↑ Xi, P et al. (2013) DDRGK1 regulates NF-κB activity by modulating IκBα stability. PLoS ONE 8 e64231 PubMed GONUTS page
c
- Catarrhini
- GO:0034614 ! cellular response to reactive oxygen species
- GO:0071276 ! cellular response to cadmium ion
- Chordata
- GO:0062023 ! collagen-containing extracellular matrix
- GO:0005518 ! collagen binding
- GO:0030574 ! collagen catabolic process
- Craniata
- GO:0019221 ! cytokine-mediated signaling pathway
e
- GO:0007566 ! embryo implantation
- GO:0035987 ! endodermal cell differentiation
- GO:0004175 ! endopeptidase activity
- GO:0048013 ! ephrin receptor signaling pathway
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0005576 ! extracellular region
- GO:0022617 ! extracellular matrix disassembly
- GO:0070062 ! extracellular exosome
- GO:0030198 ! extracellular matrix organization
- GO:0031012 ! extracellular matrix
- GO:0005615 ! extracellular space
m
n
- GO:2001258 ! negative regulation of cation channel activity
- GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development
- GO:2001268 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway
- GO:0043066 ! negative regulation of apoptotic process
- GO:0043312 ! neutrophil degranulation
p
- GO:0008233 ! peptidase activity
- GO:0090200 ! positive regulation of release of cytochrome c from mitochondria
- GO:0030335 ! positive regulation of cell migration
- GO:0043388 ! positive regulation of DNA binding
- GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway
- GO:1904707 ! positive regulation of vascular associated smooth muscle cell proliferation
- GO:0051549 ! positive regulation of keratinocyte migration
- GO:1900122 ! positive regulation of receptor binding
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0043065 ! positive regulation of apoptotic process
- Primates
- GO:0006508 ! proteolysis