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HUMAN:MMP20
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MMP20 | |
| Protein Name(s) | Matrix metalloproteinase-20
MMP-20 Enamel metalloproteinase Enamelysin | |
| External Links | ||
| UniProt | O60882 | |
| EMBL | Y12779 AY673603 AP000851 | |
| CCDS | CCDS8318.1 | |
| RefSeq | NP_004762.2 | |
| UniGene | Hs.591946 | |
| PDB | 2JSD | |
| PDBsum | 2JSD | |
| ProteinModelPortal | O60882 | |
| SMR | O60882 | |
| STRING | 9606.ENSP00000260228 | |
| BindingDB | O60882 | |
| ChEMBL | CHEMBL1938226 | |
| DrugBank | DB00786 | |
| MEROPS | M10.019 | |
| PhosphoSite | O60882 | |
| PaxDb | O60882 | |
| PRIDE | O60882 | |
| DNASU | 9313 | |
| Ensembl | ENST00000260228 | |
| GeneID | 9313 | |
| KEGG | hsa:9313 | |
| UCSC | uc001phc.3 | |
| CTD | 9313 | |
| GeneCards | GC11M102448 | |
| H-InvDB | HIX0036038 | |
| HGNC | HGNC:7167 | |
| MIM | 604629 612529 | |
| neXtProt | NX_O60882 | |
| Orphanet | 100033 | |
| PharmGKB | PA30878 | |
| eggNOG | NOG328389 | |
| GeneTree | ENSGT00760000118870 | |
| HOGENOM | HOG000217927 | |
| HOVERGEN | HBG052484 | |
| InParanoid | O60882 | |
| KO | K07999 | |
| OMA | PDVANYR | |
| OrthoDB | EOG7XPZ57 | |
| PhylomeDB | O60882 | |
| TreeFam | TF315428 | |
| Reactome | REACT_118572 REACT_150180 REACT_150401 | |
| EvolutionaryTrace | O60882 | |
| GeneWiki | MMP20 | |
| GenomeRNAi | 9313 | |
| NextBio | 34887 | |
| PRO | PR:O60882 | |
| Proteomes | UP000005640 | |
| Bgee | O60882 | |
| CleanEx | HS_MMP20 | |
| Genevestigator | O60882 | |
| GO | GO:0005576 GO:0005615 GO:0005578 GO:0005509 GO:0004222 GO:0008270 GO:0097186 GO:0030574 GO:0022617 GO:0030198 GO:0030163 GO:0006508 GO:0070173 | |
| Gene3D | 2.110.10.10 3.40.390.10 | |
| InterPro | IPR000585 IPR018487 IPR024079 IPR028716 IPR001818 IPR021190 IPR016293 IPR021158 IPR006026 IPR002477 | |
| PANTHER | PTHR10201:SF125 | |
| Pfam | PF00045 PF00413 PF01471 | |
| PIRSF | PIRSF001191 | |
| PRINTS | PR00138 | |
| SMART | SM00120 SM00235 | |
| SUPFAM | SSF47090 SSF50923 | |
| PROSITE | PS00546 PS51642 PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004222 |
metalloendopeptidase activity |
ECO:0000314 |
F |
Figure 3 |
complete | |||||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097186 |
amelogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1353466 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101900 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97005 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097186 |
amelogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P57748 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030163 |
protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P57748 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022617 |
extracellular matrix disassembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P57748 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070173 |
regulation of enamel mineralization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030574 |
collagen catabolic process |
Reactome:R-HSA-1442490 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-2168923 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Llano, E et al. (1997) Identification and structural and functional characterization of human enamelysin (MMP-20). Biochemistry 36 15101-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Tanimoto, K et al. (2008) Reduced amelogenin-MMP20 interactions in amelogenesis imperfecta. J. Dent. Res. 87 451-5 PubMed GONUTS page
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