HUMAN:MMP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MMP1 (synonyms: CLG)
Protein Name(s)	Interstitial collagenase Fibroblast collagenase Matrix metalloproteinase-1 MMP-1 22 kDa interstitial collagenase 27 kDa interstitial collagenase
External Links
UniProt	P03956
EMBL	X54925 X05231 M13509 U78045 BT006874 AY769434 BC013875 M16567 M15996
CCDS	CCDS8322.1
PIR	A37308
RefSeq	NP_002412.1
UniGene	Hs.83169
PDB	1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
PDBsum	1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
ProteinModelPortal	P03956
SMR	P03956
BioGrid	110456
DIP	DIP-529N
IntAct	P03956
MINT	MINT-198818
STRING	9606.ENSP00000322788
BindingDB	P03956
ChEMBL	CHEMBL2095216
DrugBank	DB00786
GuidetoPHARMACOLOGY	1628
MEROPS	M10.001
iPTMnet	P03956
PhosphoSite	P03956
UniCarbKB	P03956
BioMuta	MMP1
DMDM	116852
EPD	P03956
PaxDb	P03956
PeptideAtlas	P03956
PRIDE	P03956
DNASU	4312
Ensembl	ENST00000315274
GeneID	4312
UCSC	uc001phi.3
CTD	4312
GeneCards	MMP1
H-InvDB	HIX0201751
HGNC	HGNC:7155
MalaCards	MMP1
MIM	120353
neXtProt	NX_P03956
Orphanet	79408
PharmGKB	PA30867
eggNOG	KOG1565 ENOG410XQ5D
GeneTree	ENSGT00760000118870
HOGENOM	HOG000217927
HOVERGEN	HBG052484
InParanoid	P03956
OMA	FPGIGHK
OrthoDB	EOG7XPZ57
PhylomeDB	P03956
TreeFam	TF315428
BRENDA	3.4.24.7
Reactome	R-HSA-1442490 R-HSA-1474228 R-HSA-1592389 R-HSA-210991 R-HSA-381426
EvolutionaryTrace	P03956
GeneWiki	MMP1
GenomeRNAi	4312
NextBio	16969
PMAP-CutDB	P03956
PRO	PR:P03956
Proteomes	UP000005640
Bgee	P03956
CleanEx	HS_MMP1
Genevisible	P03956
GO	GO:0005576 GO:0005578 GO:0005509 GO:0004175 GO:0004222 GO:0008270 GO:0007596 GO:0044267 GO:0030574 GO:0022617 GO:0030198 GO:0050900 GO:0032461 GO:0006508 GO:0016032
Gene3D	2.110.10.10 3.40.390.10
InterPro	IPR000585 IPR018487 IPR018486 IPR024079 IPR001818 IPR021190 IPR016293 IPR021158 IPR006026 IPR002477
Pfam	PF00045 PF00413 PF01471
PIRSF	PIRSF001191
PRINTS	PR00138
SMART	SM00120 SM00235
SUPFAM	SSF47090 SSF50923
PROSITE	PS00546 PS00024 PS51642 PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016049	cell growth	PMID:19734937^[1]	ECO:0000314			P		Figure 1A: Western blot analysis of MMP-1 protein production by normal melanocytes, Bowes RGP melanoma cells, and VMM12 VPG melanoma cells, and analysis PAR-1 protein expression by normal endothelial cells, Bowes and and VMM12. PAR-1 blots were re-probed for actin, as a loading control. MMP-1 band is 54kD, PAR-1 is 61kD, actin is 43kD	complete CACAO 11744
involved_in	GO:0006508	proteolysis	PMID:15863497^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P37840) occurs_in:(GO:0005576)	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:19022250^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P37840)	Seeded From UniProt	complete
involved_in	GO:0032461	positive regulation of protein oligomerization	PMID:19022250^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P37840)	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:19022250^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P37840)	Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:9920899^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P01308)	Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101900 MGI:MGI:1276107 MGI:MGI:1340026 MGI:MGI:97008 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:621316 RGD:621320 UniProtKB:P45452	P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 FB:FBgn0035049 MGI:MGI:1340026 MGI:MGI:1353466 MGI:MGI:97008 MGI:MGI:97011 PANTHER:PTN001303987 UniProtKB:P45452 WB:WBGene00006987 ZFIN:ZDB-GENE-040426-2132	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97005 MGI:MGI:97009 PANTHER:PTN000810753 RGD:3100 RGD:620196 RGD:621316 RGD:621317 RGD:621320 RGD:631408 UniProtKB:B5DFD5 UniProtKB:P02790 UniProtKB:P08253 UniProtKB:P14780 UniProtKB:P22894 UniProtKB:P39900 UniProtKB:P50281 UniProtKB:Q90611	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 MGI:MGI:101900 MGI:MGI:1340026 MGI:MGI:1341867 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:620196 TAIR:locus:2020548 TAIR:locus:2025891 TAIR:locus:2032467 TAIR:locus:2055605 TAIR:locus:2130928 UniProtKB:O60882 UniProtKB:O75900 UniProtKB:P03956 UniProtKB:P14780 UniProtKB:P39900 UniProtKB:P45452 UniProtKB:P51512 UniProtKB:Q90611 UniProtKB:Q99542	F		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021158 InterPro:IPR021190	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021158 InterPro:IPR021190	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006026 InterPro:IPR024079 InterPro:IPR033739	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR033739	F		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021158 InterPro:IPR021190	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:2167156^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:2167156^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:3027129^[7] Reactome:R-HSA-1564169	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	Reactome:R-HSA-1442490	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022617	extracellular matrix disassembly	Reactome:R-HSA-1474228	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-3814821 Reactome:R-NUL-2533972 Reactome:R-NUL-2484869 Reactome:R-NUL-2484859 Reactome:R-HSA-6789615 Reactome:R-HSA-381435 Reactome:R-HSA-3791149 Reactome:R-HSA-375135 Reactome:R-HSA-1604690 Reactome:R-HSA-1604359 Reactome:R-HSA-1602473 Reactome:R-HSA-1592436 Reactome:R-HSA-1592316 Reactome:R-HSA-1592297 Reactome:R-HSA-1566981 Reactome:R-HSA-1564169 Reactome:R-HSA-1564120 Reactome:R-HSA-1474213 Reactome:R-HSA-1474197 Reactome:R-HSA-1454822 Reactome:R-HSA-1454781 Reactome:R-HSA-1454757	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	Reactome:R-HSA-1602473	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0177	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Blackburn, JS et al. (2009) A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis. Oncogene 28 4237-48 PubMed GONUTS page
↑ Sung, JY et al. (2005) Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J. Biol. Chem. 280 25216-24 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Levin, J et al. (2009) Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases. Exp. Neurol. 215 201-8 PubMed GONUTS page
↑ Roghani, M et al. (1999) Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. J. Biol. Chem. 274 3531-40 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Templeton, NS et al. (1990) Cloning and characterization of human tumor cell interstitial collagenase. Cancer Res. 50 5431-7 PubMed GONUTS page
↑ Brinckerhoff, CE et al. (1987) Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA. J. Clin. Invest. 79 542-6 PubMed GONUTS page

[PMID:19734937-1] Blackburn, JS et al. (2009) A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis. Oncogene 28 4237-48 PubMed GONUTS page

[PMID:15863497-2] Sung, JY et al. (2005) Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J. Biol. Chem. 280 25216-24 PubMed GONUTS page

[PMID:19022250-3] 3.0 ^3.1 ^3.2 Levin, J et al. (2009) Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases. Exp. Neurol. 215 201-8 PubMed GONUTS page

[PMID:9920899-4] Roghani, M et al. (1999) Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. J. Biol. Chem. 274 3531-40 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2167156-6] 6.0 ^6.1 Templeton, NS et al. (1990) Cloning and characterization of human tumor cell interstitial collagenase. Cancer Res. 50 5431-7 PubMed GONUTS page

[PMID:3027129-7] Brinckerhoff, CE et al. (1987) Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA. J. Clin. Invest. 79 542-6 PubMed GONUTS page

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HUMAN:MMP1

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