HUMAN:MET

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MET
Protein Name(s)	Hepatocyte growth factor receptor HGF receptor HGF/SF receptor Proto-oncogene c-Met Scatter factor receptor SF receptor Tyrosine-protein kinase Met
External Links
UniProt	P08581
EMBL	J02958 X54559 EU826570 AC002080 AC002543 AC004416 CH236947 CH471070 BC130420 U08818 M35074
CCDS	CCDS43636.1 CCDS47689.1
PIR	A40175
RefSeq	NP_000236.2 NP_001120972.1
UniGene	Hs.132966
PDB	1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZBX 3ZC5 3ZCL 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4IWD 4K3J 4KNB 4MXC 4O3T 4O3U 4R1V 4R1Y 4XMO 4XYF 5DG5 5EOB 5EYC 5EYD 5HLW 5HNI 5HO6 5HOA 5HOR 5HTI 5T3Q
PDBsum	1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZBX 3ZC5 3ZCL 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4IWD 4K3J 4KNB 4MXC 4O3T 4O3U 4R1V 4R1Y 4XMO 4XYF 5DG5 5EOB 5EYC 5EYD 5HLW 5HNI 5HO6 5HOA 5HOR 5HTI 5T3Q
ProteinModelPortal	P08581
SMR	P08581
BioGrid	110391
DIP	DIP-6023N
IntAct	P08581
MINT	MINT-4837114
STRING	9606.ENSP00000317272
BindingDB	P08581
ChEMBL	CHEMBL3717
DrugBank	DB07969 DB08875 DB08865 DB02152 DB05216 DB06995 DB05153
GuidetoPHARMACOLOGY	1815
iPTMnet	P08581
PhosphoSitePlus	P08581
SwissPalm	P08581
UniCarbKB	P08581
BioMuta	MET
DMDM	251757497
OGP	P08581
EPD	P08581
MaxQB	P08581
PaxDb	P08581
PeptideAtlas	P08581
PRIDE	P08581
DNASU	4233
Ensembl	ENST00000318493 ENST00000397752 ENST00000436117
GeneID	4233
KEGG	hsa:4233
UCSC	uc003vij.4
CTD	4233
DisGeNET	4233
GeneCards	MET
HGNC	HGNC:7029
HPA	CAB005282 CAB018577 HPA055607
MalaCards	MET
MIM	114550 164860 605074 607278 616705
neXtProt	NX_P08581
OpenTargets	ENSG00000105976
Orphanet	106 47044
PharmGKB	PA30763
eggNOG	KOG1095 KOG3610 COG0515
GeneTree	ENSGT00810000125384
HOGENOM	HOG000220900
HOVERGEN	HBG006348
InParanoid	P08581
KO	K05099
OMA	QRVDLFM
PhylomeDB	P08581
TreeFam	TF317402
BRENDA	2.7.10.1
Reactome	[www.reactome.org/content/detail/R-HSA-1257604 R-HSA-1257604] [www.reactome.org/content/detail/R-HSA-2219530 R-HSA-2219530] [www.reactome.org/content/detail/R-HSA-416550 R-HSA-416550] [www.reactome.org/content/detail/R-HSA-5673001 R-HSA-5673001] [www.reactome.org/content/detail/R-HSA-6806942 R-HSA-6806942] [www.reactome.org/content/detail/R-HSA-6807004 R-HSA-6807004] [www.reactome.org/content/detail/R-HSA-6811558 R-HSA-6811558] [www.reactome.org/content/detail/R-HSA-8851805 R-HSA-8851805] [www.reactome.org/content/detail/R-HSA-8851907 R-HSA-8851907] [www.reactome.org/content/detail/R-HSA-8865999 R-HSA-8865999] [www.reactome.org/content/detail/R-HSA-8874081 R-HSA-8874081] [www.reactome.org/content/detail/R-HSA-8875360 R-HSA-8875360] [www.reactome.org/content/detail/R-HSA-8875513 R-HSA-8875513] [www.reactome.org/content/detail/R-HSA-8875555 R-HSA-8875555] [www.reactome.org/content/detail/R-HSA-8875656 R-HSA-8875656] [www.reactome.org/content/detail/R-HSA-8875791 R-HSA-8875791]
SignaLink	P08581
SIGNOR	P08581
ChiTaRS	MET
EvolutionaryTrace	P08581
GeneWiki	C-Met
GenomeRNAi	4233
PRO	PR:P08581
Proteomes	UP000005640
Bgee	ENSG00000105976
CleanEx	HS_MET
ExpressionAtlas	P08581
Genevisible	P08581
GO	GO:0009925 GO:0009986 GO:0005576 GO:0016021 GO:0005887 GO:0005622 GO:0005886 GO:0005524 GO:0005008 GO:0046934 GO:0019903 GO:0004713 GO:0005088 GO:0048754 GO:0008283 GO:0007166 GO:0001886 GO:0035635 GO:0000165 GO:0010507 GO:1901299 GO:0048015 GO:0050918 GO:2001028 GO:0045944 GO:0014066 GO:0071526 GO:0007165
Gene3D	2.130.10.10 2.60.40.10
InterPro	IPR013783 IPR014756 IPR002909 IPR011009 IPR002165 IPR000719 IPR017441 IPR016201 IPR001627 IPR001245 IPR008266 IPR020635 IPR016244 IPR015943
Pfam	PF07714 PF01437 PF01403 PF01833
PIRSF	PIRSF000617
PRINTS	PR00109
SMART	SM00429 SM00423 SM00630 SM00219
SUPFAM	SSF101912 SSF56112 SSF81296
PROSITE	PS00107 PS50011 PS00109 PS51004

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway	PMID:25198505^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000066)	Seeded From UniProt	complete
involved_in	GO:0051497	negative regulation of stress fiber assembly	PMID:25198505^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035024	negative regulation of Rho protein signal transduction	PMID:25198505^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity	PMID:25198505^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q92974)	Seeded From UniProt	complete
involved_in	GO:0061436	establishment of skin barrier	PMID:25198505^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000066)	Seeded From UniProt	complete
involved_in	GO:0031116	positive regulation of microtubule polymerization	PMID:25198505^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000066)	Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:24743740^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	occurs_in:(CL:0010021)	Seeded From UniProt	complete
involved_in	GO:0001886	endothelial cell morphogenesis	PMID:14500721^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19581412^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	PMID:20655899^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22521434^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001028	positive regulation of endothelial cell chemotaxis	PMID:19850054^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	PMID:15218527^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	PMID:15218527^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	PMID:16153003^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0001656)	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:18819921^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17706	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:18819921^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18031	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:2819873^[11]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:2819873^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:3325883^[12]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814515 RGD:3082 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814515 RGD:3082 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0033791 MGI:MGI:101766 PANTHER:PTN002521290	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 MGI:MGI:96969 PANTHER:PTN002814495 RGD:3082 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101766 PANTHER:PTN002521290	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 MGI:MGI:96969 PANTHER:PTN002814495 RGD:3082 WB:WBGene00020504 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 PANTHER:PTN001231011 RGD:69283 UniProtKB:P30530 UniProtKB:Q12866	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005008	hepatocyte growth factor-activated receptor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96969 PANTHER:PTN002814515 RGD:3082	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96969 PANTHER:PTN002814515 RGD:3082 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	PMID:15314156^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20624990^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08581	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16537482^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08581	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0048012	hepatocyte growth factor receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005008	P		Seeded From UniProt	complete
involved_in	GO:0048012	hepatocyte growth factor receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005008	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016244	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016244 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016244	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016244	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:1846706^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:1846706^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005008	hepatocyte growth factor-activated receptor activity	PMID:10871856^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035635	entry of bacterium into host cell	Reactome:R-HSA-8875360	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8986940 Reactome:R-HSA-8876258 Reactome:R-HSA-8876240 Reactome:R-HSA-8876230 Reactome:R-HSA-8876210 Reactome:R-HSA-8875817 Reactome:R-HSA-8875816 Reactome:R-HSA-8875661 Reactome:R-HSA-8875659 Reactome:R-HSA-8875591 Reactome:R-HSA-8875576 Reactome:R-HSA-8875568 Reactome:R-HSA-8875558 Reactome:R-HSA-8875540 Reactome:R-HSA-8875531 Reactome:R-HSA-8875523 Reactome:R-HSA-8875490 Reactome:R-HSA-8875482 Reactome:R-HSA-8875451 Reactome:R-HSA-8875443 Reactome:R-HSA-8875431 Reactome:R-HSA-8875374 Reactome:R-HSA-8875371 Reactome:R-HSA-8875183 Reactome:R-HSA-8874685 Reactome:R-HSA-8874083 Reactome:R-HSA-8874082 Reactome:R-HSA-8874080 Reactome:R-HSA-8874079 Reactome:R-HSA-8874078 Reactome:R-HSA-8865994 Reactome:R-HSA-8852019 Reactome:R-HSA-8851954 Reactome:R-HSA-8851933 Reactome:R-HSA-8851919 Reactome:R-HSA-8851908 Reactome:R-HSA-8851900 Reactome:R-HSA-8851899 Reactome:R-HSA-8851890 Reactome:R-HSA-8851888 Reactome:R-HSA-8851877 Reactome:R-HSA-8851866 Reactome:R-HSA-8851859 Reactome:R-HSA-8851842 Reactome:R-HSA-8851827 Reactome:R-HSA-8851804 Reactome:R-HSA-6807027 Reactome:R-HSA-6807008 Reactome:R-HSA-6806974 Reactome:R-HSA-6806957 Reactome:R-HSA-6800298 Reactome:R-HSA-5672965 Reactome:R-HSA-419646 Reactome:R-HSA-416562 Reactome:R-HSA-416559 Reactome:R-HSA-416546 Reactome:R-HSA-400682 Reactome:R-HSA-400677 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	Reactome:R-HSA-419646	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
	GO:0048012	hepatocyte growth factor receptor signaling pathway	PMID:28418914^[19]	ECO:0000315			P		Regulates the function of hepatocyte growth signaling and regulation.	complete CACAO 12749
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Tian, X et al. (2014) Microtubule dynamics control HGF-induced lung endothelial barrier enhancement. PLoS ONE 9 e105912 PubMed GONUTS page
↑ Gallo, S et al. (2014) Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy. Cell Death Dis 5 e1185 PubMed GONUTS page
↑ Zlot, C et al. (2003) Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor. J. Biol. Chem. 278 47654-9 PubMed GONUTS page
↑ Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page
↑ Hu, ZX et al. (2010) Hepatocyte growth factor protects human embryonic stem cell derived-neural progenitors from hydrogen peroxide-induced apoptosis. Eur. J. Pharmacol. 645 23-31 PubMed GONUTS page
↑ Chen, K et al. (2012) Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. Bone 51 69-77 PubMed GONUTS page
↑ Sadanandam, A et al. (2010) Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvasc. Res. 79 1-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Artigiani, S et al. (2004) Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep. 5 710-4 PubMed GONUTS page
↑ Vattimo, Mde F & Santos, OF (2005) Functional interface between cathepsins and growth factors in the kidney development. Ren Fail 27 615-22 PubMed GONUTS page
↑ ^10.0 ^10.1 Sangwan, V et al. (2008) Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J. Biol. Chem. 283 34374-83 PubMed GONUTS page
↑ ^11.0 ^11.1 Park, M et al. (1987) Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc. Natl. Acad. Sci. U.S.A. 84 6379-83 PubMed GONUTS page
↑ Chan, AM et al. (1987) Primary structure of the met protein tyrosine kinase domain. Oncogene 1 229-33 PubMed GONUTS page
↑ ^13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Higuchi, T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol. Cell. Biol. 24 7456-68 PubMed GONUTS page
↑ Tolbert, WD et al. (2010) Structural basis for agonism and antagonism of hepatocyte growth factor. Proc. Natl. Acad. Sci. U.S.A. 107 13264-9 PubMed GONUTS page
↑ Gherardi, E et al. (2006) Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc. Natl. Acad. Sci. U.S.A. 103 4046-51 PubMed GONUTS page
↑ ^17.0 ^17.1 Bottaro, DP et al. (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251 802-4 PubMed GONUTS page
↑ Follenzi, A et al. (2000) Cross-talk between the proto-oncogenes Met and Ron. Oncogene 19 3041-9 PubMed GONUTS page
↑ Saffroy, R et al. (2017) MET exon 14 mutations as targets in routine molecular analysis of primary sarcomatoid carcinoma of the lung. Oncotarget PubMed GONUTS page

[PMID:25198505-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Tian, X et al. (2014) Microtubule dynamics control HGF-induced lung endothelial barrier enhancement. PLoS ONE 9 e105912 PubMed GONUTS page

[PMID:24743740-2] Gallo, S et al. (2014) Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy. Cell Death Dis 5 e1185 PubMed GONUTS page

[PMID:14500721-3] Zlot, C et al. (2003) Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor. J. Biol. Chem. 278 47654-9 PubMed GONUTS page

[PMID:19581412-4] Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page

[PMID:20655899-5] Hu, ZX et al. (2010) Hepatocyte growth factor protects human embryonic stem cell derived-neural progenitors from hydrogen peroxide-induced apoptosis. Eur. J. Pharmacol. 645 23-31 PubMed GONUTS page

[PMID:22521434-6] Chen, K et al. (2012) Hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D together stimulate human bone marrow-derived stem cells toward the osteogenic phenotype by HGF-induced up-regulation of VDR. Bone 51 69-77 PubMed GONUTS page

[PMID:19850054-7] Sadanandam, A et al. (2010) Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvasc. Res. 79 1-9 PubMed GONUTS page

[PMID:15218527-8] 8.0 ^8.1 Artigiani, S et al. (2004) Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep. 5 710-4 PubMed GONUTS page

[PMID:16153003-9] Vattimo, Mde F & Santos, OF (2005) Functional interface between cathepsins and growth factors in the kidney development. Ren Fail 27 615-22 PubMed GONUTS page

[PMID:18819921-10] 10.0 ^10.1 Sangwan, V et al. (2008) Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J. Biol. Chem. 283 34374-83 PubMed GONUTS page

[PMID:2819873-11] 11.0 ^11.1 Park, M et al. (1987) Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc. Natl. Acad. Sci. U.S.A. 84 6379-83 PubMed GONUTS page

[PMID:3325883-12] Chan, AM et al. (1987) Primary structure of the met protein tyrosine kinase domain. Oncogene 1 229-33 PubMed GONUTS page

[PMID:21873635-13] 13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15314156-14] Higuchi, T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol. Cell. Biol. 24 7456-68 PubMed GONUTS page

[PMID:20624990-15] Tolbert, WD et al. (2010) Structural basis for agonism and antagonism of hepatocyte growth factor. Proc. Natl. Acad. Sci. U.S.A. 107 13264-9 PubMed GONUTS page

[PMID:16537482-16] Gherardi, E et al. (2006) Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc. Natl. Acad. Sci. U.S.A. 103 4046-51 PubMed GONUTS page

[PMID:1846706-17] 17.0 ^17.1 Bottaro, DP et al. (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251 802-4 PubMed GONUTS page

[PMID:10871856-18] Follenzi, A et al. (2000) Cross-talk between the proto-oncogenes Met and Ron. Oncogene 19 3041-9 PubMed GONUTS page

[PMID:28418914-19] Saffroy, R et al. (2017) MET exon 14 mutations as targets in routine molecular analysis of primary sarcomatoid carcinoma of the lung. Oncotarget PubMed GONUTS page

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HUMAN:MET

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