HUMAN:MEIS1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MEIS1
Protein Name(s)	Homeobox protein Meis1
External Links
UniProt	O00470
EMBL	U85707 CR612956 AC007392 AC092669 AC093641 BC043503
CCDS	CCDS46309.1
RefSeq	NP_002389.1
UniGene	Hs.526754 Hs.603755
ProteinModelPortal	O00470
SMR	O00470
BioGrid	110375
IntAct	O00470
STRING	9606.ENSP00000272369
PhosphoSite	O00470
MaxQB	O00470
PaxDb	O00470
PRIDE	O00470
Ensembl	ENST00000272369 ENST00000398506
GeneID	4211
KEGG	hsa:4211
UCSC	uc002sdt.3
CTD	4211
GeneCards	GC02P066660
HGNC	HGNC:7000
HPA	CAB011521 HPA056000
MIM	601739 612853
neXtProt	NX_O00470
PharmGKB	PA30740
eggNOG	NOG302919
GeneTree	ENSGT00550000074260
HOGENOM	HOG000253923
HOVERGEN	HBG055193
InParanoid	O00470
KO	K15613
PhylomeDB	O00470
TreeFam	TF318093
SignaLink	O00470
ChiTaRS	MEIS1
GeneWiki	MEIS1
GenomeRNAi	4211
NextBio	16590
PRO	PR:O00470
Proteomes	UP000005640
Bgee	O00470
CleanEx	HS_MEIS1
ExpressionAtlas	O00470
Genevestigator	O00470
GO	GO:0005634 GO:0005667 GO:0003682 GO:0000978 GO:0001077 GO:0003705 GO:0001525 GO:0060216 GO:0002089 GO:0035855 GO:0045638 GO:0045665
Gene3D	1.10.10.60
InterPro	IPR001356 IPR008422 IPR009057
Pfam	PF05920
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0001525	angiogenesis	PMID:24642863^[1]	ECO:0000314			P	Figure 1: epigenetic signatures in vitro	complete CACAO 10643
enables	GO:0003677	DNA binding	PMID:26550823^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001356 InterPro:IPR009057	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q9ER75	F	Seeded From UniProt	complete
involved_in	GO:0045638	negative regulation of myeloid cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60954	P	Seeded From UniProt	complete
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B1WC31 ensembl:ENSRNOP00000006157	P	Seeded From UniProt	complete
involved_in	GO:0060216	definitive hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
involved_in	GO:0045638	negative regulation of myeloid cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	F	Seeded From UniProt	complete
involved_in	GO:0035855	megakaryocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	F	Seeded From UniProt	complete
involved_in	GO:0002089	lens morphogenesis in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	P	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60954 ensembl:ENSMUSP00000139219	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR008422 InterPro:IPR009057	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008422	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Spieler, D et al. (2014) Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res. 24 592-603 PubMed GONUTS page
↑ Jolma, A et al. (2015) DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527 384-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:24642863-1] Spieler, D et al. (2014) Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res. 24 592-603 PubMed GONUTS page

[PMID:26550823-2] Jolma, A et al. (2015) DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527 384-8 PubMed GONUTS page

[PMID:19274049-3] 3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

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HUMAN:MEIS1

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