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HUMAN:MEIS1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MEIS1
Protein Name(s) Homeobox protein Meis1
External Links
UniProt O00470
EMBL U85707
CR612956
AC007392
AC092669
AC093641
BC043503
CCDS CCDS46309.1
RefSeq NP_002389.1
UniGene Hs.526754
Hs.603755
ProteinModelPortal O00470
SMR O00470
BioGrid 110375
IntAct O00470
STRING 9606.ENSP00000272369
PhosphoSite O00470
MaxQB O00470
PaxDb O00470
PRIDE O00470
Ensembl ENST00000272369
ENST00000398506
GeneID 4211
KEGG hsa:4211
UCSC uc002sdt.3
CTD 4211
GeneCards GC02P066660
HGNC HGNC:7000
HPA CAB011521
HPA056000
MIM 601739
612853
neXtProt NX_O00470
PharmGKB PA30740
eggNOG NOG302919
GeneTree ENSGT00550000074260
HOGENOM HOG000253923
HOVERGEN HBG055193
InParanoid O00470
KO K15613
PhylomeDB O00470
TreeFam TF318093
SignaLink O00470
ChiTaRS MEIS1
GeneWiki MEIS1
GenomeRNAi 4211
NextBio 16590
PRO PR:O00470
Proteomes UP000005640
Bgee O00470
CleanEx HS_MEIS1
ExpressionAtlas O00470
Genevestigator O00470
GO GO:0005634
GO:0005667
GO:0003682
GO:0000978
GO:0001077
GO:0003705
GO:0001525
GO:0060216
GO:0002089
GO:0035855
GO:0045638
GO:0045665
Gene3D 1.10.10.60
InterPro IPR001356
IPR008422
IPR009057
Pfam PF05920
SMART SM00389
SUPFAM SSF46689
PROSITE PS50071

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001525

angiogenesis

PMID:24642863[1]

ECO:0000314

P

Figure 1: epigenetic signatures in vitro

complete
CACAO 10643

enables

GO:0003677

DNA binding

PMID:26550823[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[3]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q9ER75

F

Seeded From UniProt

complete

involved_in

GO:0045638

negative regulation of myeloid cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60954

P

Seeded From UniProt

complete

involved_in

GO:0060044

negative regulation of cardiac muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B1WC31
ensembl:ENSRNOP00000006157

P

Seeded From UniProt

complete

involved_in

GO:0060216

definitive hemopoiesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

involved_in

GO:0048514

blood vessel morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

involved_in

GO:0045665

negative regulation of neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

involved_in

GO:0045638

negative regulation of myeloid cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

F

Seeded From UniProt

complete

involved_in

GO:0035855

megakaryocyte development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

involved_in

GO:0030097

hemopoiesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

involved_in

GO:0007626

locomotory behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

F

Seeded From UniProt

complete

involved_in

GO:0002089

lens morphogenesis in camera-type eye

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60954
ensembl:ENSMUSP00000139219

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001356
InterPro:IPR008422
InterPro:IPR009057

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008422

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0371
UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Spieler, D et al. (2014) Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res. 24 592-603 PubMed GONUTS page
  2. Jolma, A et al. (2015) DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527 384-8 PubMed GONUTS page
  3. 3.0 3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page