HUMAN:MCM9

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MCM9 (synonyms: C6orf61, MCMDC1)
Protein Name(s)	DNA helicase MCM9 hMCM9 Mini-chromosome maintenance deficient domain-containing protein 1 Minichromosome maintenance 9
External Links
UniProt	Q9NXL9
EMBL	AK299076 AK000177 AL132874 AL359634 BC031658 BN000882
CCDS	CCDS5121.1 CCDS56447.1
RefSeq	NP_060166.2 NP_694987.1
UniGene	Hs.279008 Hs.733116 Hs.736853
ProteinModelPortal	Q9NXL9
SMR	Q9NXL9
BioGrid	129033
IntAct	Q9NXL9
STRING	9606.ENSP00000312870
PhosphoSite	Q9NXL9
DMDM	387912921
MaxQB	Q9NXL9
PaxDb	Q9NXL9
PRIDE	Q9NXL9
DNASU	254394
Ensembl	ENST00000316068 ENST00000316316 ENST00000619706
GeneID	254394
KEGG	hsa:254394
UCSC	uc003pyh.3 uc021zeh.1
CTD	254394
GeneCards	GC06M119136
HGNC	HGNC:21484
HPA	HPA031137
MIM	610098
neXtProt	NX_Q9NXL9
PharmGKB	PA162395071
eggNOG	COG1241
GeneTree	ENSGT00740000115337
HOGENOM	HOG000169812
HOVERGEN	HBG108122
InParanoid	Q9NXL9
KO	K10738
OMA	EDFWEHY
OrthoDB	EOG7TQV0G
PhylomeDB	Q9NXL9
TreeFam	TF329421
ChiTaRS	MCM9
GenomeRNAi	254394
NextBio	92339
PRO	PR:Q9NXL9
Proteomes	UP000005640
Bgee	Q9NXL9
CleanEx	HS_MCM9
ExpressionAtlas	Q9NXL9
Genevestigator	Q9NXL9
GO	GO:0097362 GO:0005634 GO:0005524 GO:0003677 GO:0004386 GO:0006974 GO:0006260 GO:0000724 GO:0007292
Gene3D	2.40.50.140 3.40.50.300
InterPro	IPR003593 IPR001208 IPR012340 IPR027417
Pfam	PF00493
PRINTS	PR01657
SMART	SM00382 SM00350
SUPFAM	SSF50249 SSF52540
PROSITE	PS50051

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0097362	MCM8-MCM9 complex	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:26300262^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJA3	F		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:23401855^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036298	recombinational interstrand cross-link repair	PMID:23401855^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0006260	DNA replication	PMID:23401855^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9UJA3	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23401855^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097362	MCM8-MCM9 complex	PMID:23401855^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:26215093^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(GO:0030870)	Seeded From UniProt	complete
part_of	GO:0097362	MCM8-MCM9 complex	PMID:26215093^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:23401855^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0006974)	Seeded From UniProt	complete
involved_in	GO:0070716	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	PMID:26300262^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:26300262^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003678	DNA helicase activity	PMID:26300262^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	PMID:26300262^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P40692)	Seeded From UniProt	complete
enables	GO:0032406	MutLbeta complex binding	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032407	MutSalpha complex binding	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032408	MutSbeta complex binding	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23401855^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJA3	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	PMID:23401855^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0000724) has_regulation_target:(UniProtKB:Q06609)	Seeded From UniProt	complete
part_of	GO:0097362	MCM8-MCM9 complex	PMID:22771115^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007292	female gamete generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2KHI9	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:22771115^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:22771115^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097362	MCM8-MCM9 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2KHI9 ensembl:ENSMUSP00000074978	C		Seeded From UniProt	complete
involved_in	GO:0036298	recombinational interstrand cross-link repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2KHI9 ensembl:ENSMUSP00000074978	P		Seeded From UniProt	complete
involved_in	GO:0007292	female gamete generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2KHI9 ensembl:ENSMUSP00000074978	P		Seeded From UniProt	complete
involved_in	GO:0007276	gamete generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2KHI9 ensembl:ENSMUSP00000074978	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2KHI9 ensembl:ENSMUSP00000074978	P		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2KHI9 ensembl:ENSMUSP00000074978	F		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q2KHI9 ensembl:ENSMUSP00000074978	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001208	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001208	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Park, J et al. (2013) The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol. Cell. Biol. 33 1632-44 PubMed GONUTS page
↑ ^3.0 ^3.1 Lee, KY et al. (2015) MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun 6 7744 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Nishimura, K et al. (2012) Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. Mol. Cell 47 511-22 PubMed GONUTS page

[PMID:26300262-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page

[PMID:23401855-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Park, J et al. (2013) The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol. Cell. Biol. 33 1632-44 PubMed GONUTS page

[PMID:26215093-3] 3.0 ^3.1 Lee, KY et al. (2015) MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun 6 7744 PubMed GONUTS page

[PMID:22771115-4] 4.0 ^4.1 ^4.2 Nishimura, K et al. (2012) Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. Mol. Cell 47 511-22 PubMed GONUTS page

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HUMAN:MCM9

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