HUMAN:MCM8

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MCM8 (synonyms: C20orf154)
Protein Name(s)	DNA helicase MCM8 Minichromosome maintenance 8
External Links
UniProt	Q9UJA3
EMBL	AJ439063 AY158211 AK027644 AK314654 AL035461 AL035461 CH471133 CH471133 BC008830 BC080656 BC101054 BC101055 BC101056 BC101057
CCDS	CCDS13094.1 CCDS13095.1 CCDS63226.1 CCDS63227.1
RefSeq	NP_001268449.1 NP_001268450.1 NP_001268451.1 NP_115874.3 NP_877954.1
UniGene	Hs.597484
ProteinModelPortal	Q9UJA3
SMR	Q9UJA3
BioGrid	124109
IntAct	Q9UJA3
STRING	9606.ENSP00000368174
PhosphoSite	Q9UJA3
DMDM	27805609
MaxQB	Q9UJA3
PaxDb	Q9UJA3
PRIDE	Q9UJA3
Ensembl	ENST00000265187 ENST00000378883 ENST00000378886 ENST00000378896 ENST00000610722
GeneID	84515
KEGG	hsa:84515
UCSC	uc002wmi.3 uc002wmj.3 uc002wmk.3 uc010gbp.3
CTD	84515
GeneCards	GC20P005926
HGNC	HGNC:16147
HPA	HPA045141
MIM	608187
neXtProt	NX_Q9UJA3
PharmGKB	PA25696
eggNOG	COG1241
GeneTree	ENSGT00770000120580
HOVERGEN	HBG031700
InParanoid	Q9UJA3
KO	K10737
OMA	LIVNSLC
OrthoDB	EOG7966G8
PhylomeDB	Q9UJA3
TreeFam	TF323155
Reactome	REACT_1095 REACT_1156 REACT_1321 REACT_1707 REACT_1949 REACT_207 REACT_2243 REACT_6769 REACT_6776
ChiTaRS	MCM8
GeneWiki	MCM8
GenomeRNAi	84515
NextBio	74316
PRO	PR:Q9UJA3
Proteomes	UP000005640
Bgee	Q9UJA3
CleanEx	HS_MCM8
Genevestigator	Q9UJA3
GO	GO:0097362 GO:0005654 GO:0005634 GO:0005524 GO:0003677 GO:0004386 GO:0006974 GO:0006260 GO:0006271 GO:0000724 GO:0007292 GO:0000082 GO:0048232 GO:0000278
Gene3D	2.40.50.140 3.40.50.300
InterPro	IPR003593 IPR001208 IPR027925 IPR012340 IPR027417
Pfam	PF00493 PF14551
PRINTS	PR01657
SMART	SM00382 SM00350
SUPFAM	SSF50249 SSF52540
PROSITE	PS50051

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0050821	protein stabilization	PMID:26215093^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	stabilizes:(UniProtKB:Q9NXL9)	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:23401855^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	stabilizes:(UniProtKB:Q9NXL9)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:26300262^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NXL9	F		Seeded From UniProt	complete
part_of	GO:0097362	MCM8-MCM9 complex	PMID:26300262^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:23401855^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036298	recombinational interstrand cross-link repair	PMID:23401855^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0006260	DNA replication	PMID:23401855^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9NXL9	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23401855^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097362	MCM8-MCM9 complex	PMID:23401855^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:26215093^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NXL9	F		Seeded From UniProt	complete
part_of	GO:0097362	MCM8-MCM9 complex	PMID:26215093^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:23401855^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0006974)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26300262^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0032406	MutLbeta complex binding	PMID:26300262^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032407	MutSalpha complex binding	PMID:26300262^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0032408	MutSbeta complex binding	PMID:26300262^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23401855^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NXL9	F		Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	PMID:23401855^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0000724) has_regulation_target:(UniProtKB:Q06609)	Seeded From UniProt	complete
part_of	GO:0097362	MCM8-MCM9 complex	PMID:22771115^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048232	male gamete generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CWV1	P		Seeded From UniProt	complete
involved_in	GO:0007292	female gamete generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CWV1	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:22771115^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001208	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001208	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	Reactome:R-HSA-176318	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-68944 Reactome:R-HSA-68940 Reactome:R-HSA-68919 Reactome:R-HSA-68918 Reactome:R-HSA-68917 Reactome:R-HSA-68916 Reactome:R-HSA-68849 Reactome:R-HSA-68826 Reactome:R-HSA-68688 Reactome:R-HSA-176973 Reactome:R-HSA-176318 Reactome:R-HSA-176298	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	Reactome:R-HSA-69206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lee, KY et al. (2015) MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun 6 7744 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Park, J et al. (2013) The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol. Cell. Biol. 33 1632-44 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Nishimura, K et al. (2012) Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. Mol. Cell 47 511-22 PubMed GONUTS page

[PMID:26215093-1] 1.0 ^1.1 ^1.2 Lee, KY et al. (2015) MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun 6 7744 PubMed GONUTS page

[PMID:23401855-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Park, J et al. (2013) The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol. Cell. Biol. 33 1632-44 PubMed GONUTS page

[PMID:26300262-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page

[PMID:22771115-4] 4.0 ^4.1 Nishimura, K et al. (2012) Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks. Mol. Cell 47 511-22 PubMed GONUTS page

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HUMAN:MCM8

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