HUMAN:MCL1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MCL1 (synonyms: BCL2L3)
Protein Name(s)	Induced myeloid leukemia cell differentiation protein Mcl-1 Bcl-2-like protein 3 Bcl2-L-3 Bcl-2-related protein EAT/mcl1 mcl1/EAT
External Links
UniProt	Q07820
EMBL	L08246 AF118124 AF147742 AF198614 AF198614 AF162677 AF162676 AF203373 BT006640 AK312508 DQ088966 AL356356 AL356356 CH471121 CH471121 CH471121 CH471121 BC017197 BC071897 BC107735 AF118276 AF118277 AF118278
CCDS	CCDS956.1 CCDS957.1
PIR	A47476
RefSeq	NP_001184249.1 NP_068779.1 NP_877495.1
UniGene	Hs.632486
PDB	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6
PDBsum	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6
ProteinModelPortal	Q07820
SMR	Q07820
BioGrid	110338
DIP	DIP-231N
IntAct	Q07820
MINT	MINT-89669
BindingDB	Q07820
ChEMBL	CHEMBL4361
PhosphoSite	Q07820
DMDM	83304396
MaxQB	Q07820
PaxDb	Q07820
PRIDE	Q07820
DNASU	4170
Ensembl	ENST00000307940 ENST00000369026
GeneID	4170
KEGG	hsa:4170
UCSC	uc001euz.3 uc001eva.3
CTD	4170
GeneCards	GC01M150547
HGNC	HGNC:6943
HPA	CAB002781 HPA008455 HPA031125
MIM	159552
neXtProt	NX_Q07820
PharmGKB	PA30688
eggNOG	NOG282183
GeneTree	ENSGT00510000048923
HOVERGEN	HBG003527
InParanoid	Q07820
KO	K02539
OMA	KDTKPMG
OrthoDB	EOG7S2209
PhylomeDB	Q07820
TreeFam	TF315834
ChiTaRS	MCL1
EvolutionaryTrace	Q07820
GeneWiki	MCL1
GenomeRNAi	4170
NextBio	16422
PMAP-CutDB	Q07820
PRO	PR:Q07820
Proteomes	UP000005640
Bgee	Q07820
CleanEx	HS_MCL1
ExpressionAtlas	Q07820
Genevestigator	Q07820
GO	GO:0097136 GO:0005737 GO:0005829 GO:0016021 GO:0016020 GO:0005759 GO:0005741 GO:0005739 GO:0005654 GO:0005634 GO:0051434 GO:0015266 GO:0046982 GO:0042803 GO:0008637 GO:0001709 GO:0019725 GO:0097192 GO:0008630 GO:0007275 GO:2000811 GO:2001240 GO:2001243 GO:1903378 GO:0071806 GO:2001020 GO:0034097
InterPro	IPR013281 IPR002475 IPR020717 IPR020726 IPR020728 IPR026298
PANTHER	PTHR11256 PTHR11256:SF6
Pfam	PF00452
PRINTS	PR01866 PR01862
PROSITE	PS50062 PS01080 PS01258 PS01259

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20041405^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:24113155^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	PMID:23858059^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9WVS6	P	occurs_in:(CL:0000530) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0051434	BH3 domain binding	PMID:21036904^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55957	F		Seeded From UniProt	complete
enables	GO:0051434	BH3 domain binding	PMID:21036904^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16611	F		Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:20921992^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(UniProtKB:O54918)	Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	PMID:22277751^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:16543145^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097136	Bcl-2 family protein complex	PMID:21199865^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10837489^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10837489^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16611	F		Seeded From UniProt	complete
involved_in	GO:0019725	cellular homeostasis	PMID:10837489^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97287	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97287	C		Seeded From UniProt	complete
involved_in	GO:0001709	cell fate determination	PMID:10837489^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135647 UniProtKB:P10415 UniProtKB:Q07817 ZFIN:ZDB-GENE-010730-1	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:108052 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 UniProtKB:Q07820	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2199 RGD:2200 RGD:620525 RGD:620621 RGD:620717 RGD:621635 RGD:70984 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q07820 UniProtKB:Q16611 UniProtKB:Q92843 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-030825-1 ZFIN:ZDB-GENE-051012-1	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:102687 MGI:MGI:88138 MGI:MGI:88139 PANTHER:PTN000135647 RGD:2199 RGD:2200 RGD:620525 UniProtKB:P10415 UniProtKB:Q07817 UniProtKB:Q07820 UniProtKB:Q92843 WB:WBGene00000423 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-010730-1	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330841 MGI:MGI:1858494 MGI:MGI:99702 PANTHER:PTN000135648 RGD:621635 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q16611	F		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029131 MGI:MGI:101769 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648	P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2200 UniProtKB:P10415 UniProtKB:Q07817 WB:WBGene00000423	C		Seeded From UniProt	complete
involved_in	GO:2001020	regulation of response to DNA damage stimulus	PMID:20467439^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:9184696^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7896880^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:7896880^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20467439^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071806	protein transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008320	P		Seeded From UniProt	complete
involved_in	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	P		Seeded From UniProt	complete
enables	GO:0051434	BH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	C		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97287 ensembl:ENSMUSP00000044048	C		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020717 InterPro:IPR020726 InterPro:IPR020728 InterPro:IPR026298 InterPro:IPR036834	P		Seeded From UniProt	complete
enables	GO:0008320	protein transmembrane transporter activity	PMID:10837489^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:10837489^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10837489^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6790041	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Xiong, Y et al. (2010) Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 51 836-45 PubMed GONUTS page
↑ Kalkat, M et al. (2013) Placental autophagy regulation by the BOK-MCL1 rheostat. Autophagy 9 2140-53 PubMed GONUTS page
↑ Ekholm-Reed, S et al. (2013) Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol. Cell. Biol. 33 3627-43 PubMed GONUTS page
↑ ^4.0 ^4.1 Liu, Q & Gehring, K (2010) Heterodimerization of BAK and MCL-1 activated by detergent micelles. J. Biol. Chem. 285 41202-10 PubMed GONUTS page
↑ Jamil, S et al. (2010) Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim. Biochem. Cell Biol. 88 809-18 PubMed GONUTS page
↑ Chunhacha, P et al. (2012) Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells. Am. J. Physiol., Cell Physiol. 302 C1284-92 PubMed GONUTS page
↑ Maurer, U et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21 749-60 PubMed GONUTS page
↑ Czabotar, PE et al. (2011) Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J. Biol. Chem. 286 7123-31 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Bae, J et al. (2000) MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J. Biol. Chem. 275 25255-61 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 Pawlikowska, P et al. (2010) ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response. Cell Death Differ. 17 1739-50 PubMed GONUTS page
↑ Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page
↑ ^13.0 ^13.1 Yang, T et al. (1995) The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2. J. Cell Biol. 128 1173-84 PubMed GONUTS page

[PMID:20041405-1] Xiong, Y et al. (2010) Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 51 836-45 PubMed GONUTS page

[PMID:24113155-2] Kalkat, M et al. (2013) Placental autophagy regulation by the BOK-MCL1 rheostat. Autophagy 9 2140-53 PubMed GONUTS page

[PMID:23858059-3] Ekholm-Reed, S et al. (2013) Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol. Cell. Biol. 33 3627-43 PubMed GONUTS page

[PMID:21036904-4] 4.0 ^4.1 Liu, Q & Gehring, K (2010) Heterodimerization of BAK and MCL-1 activated by detergent micelles. J. Biol. Chem. 285 41202-10 PubMed GONUTS page

[PMID:20921992-5] Jamil, S et al. (2010) Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim. Biochem. Cell Biol. 88 809-18 PubMed GONUTS page

[PMID:22277751-6] Chunhacha, P et al. (2012) Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells. Am. J. Physiol., Cell Physiol. 302 C1284-92 PubMed GONUTS page

[PMID:16543145-7] Maurer, U et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21 749-60 PubMed GONUTS page

[PMID:21199865-8] Czabotar, PE et al. (2011) Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J. Biol. Chem. 286 7123-31 PubMed GONUTS page

[PMID:10837489-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Bae, J et al. (2000) MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J. Biol. Chem. 275 25255-61 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20467439-11] 11.0 ^11.1 Pawlikowska, P et al. (2010) ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response. Cell Death Differ. 17 1739-50 PubMed GONUTS page

[PMID:9184696-12] Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page

[PMID:7896880-13] 13.0 ^13.1 Yang, T et al. (1995) The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2. J. Cell Biol. 128 1173-84 PubMed GONUTS page

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HUMAN:MCL1

Contents

Annotations

Notes

References

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